Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation

Quantitative subcellular metabolomic measurements can explain the roles of metabolites in cellular processes but are subject to multiple confounding factors. We developed stable isotope labeling of essential nutrients in cell culture-subcellular fractionation (SILEC-SF), which uses isotope-labeled i...

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Vydáno v:	Molecular cell Ročník 82; číslo 2; s. 447
Hlavní autoři:	Trefely, Sophie, Huber, Katharina, Liu, Joyce, Noji, Michael, Stransky, Stephanie, Singh, Jay, Doan, Mary T, Lovell, Claudia D, von Krusenstiern, Eliana, Jiang, Helen, Bostwick, Anna, Pepper, Hannah L, Izzo, Luke, Zhao, Steven, Xu, Jimmy P, Bedi, Jr, Kenneth C, Rame, J Eduardo, Bogner-Strauss, Juliane G, Mesaros, Clementina, Sidoli, Simone, Wellen, Kathryn E, Snyder, Nathaniel W
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 20.01.2022
Témata:	Acyl Coenzyme A - metabolism Animals Cell Compartmentation Cell Differentiation Cell Nucleus - metabolism Chromatography, Liquid Cytosol - metabolism Energy Metabolism Epigenesis, Genetic Hep G2 Cells Histones - metabolism Humans Isoleucine Metabolome Metabolomics Mice Mitochondria - metabolism Oxygen - metabolism Protein Processing, Post-Translational Spectrometry, Mass, Electrospray Ionization propionylation acyl-CoA internal standard metabolomics mitochondria matrix effects subcellular nucleus branched chain amino acids histone isoleucine
ISSN:	1097-4164, 1097-4164
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