Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis

Background The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This s...

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Vydané v:BMC neurology Ročník 13; číslo 1; s. 37
Hlavní autori: Learmonth, Yvonne C, Motl, Robert W, Sandroff, Brian M, Pula, John H, Cadavid, Diego
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 25.04.2013
BioMed Central Ltd
Springer Nature B.V
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ISSN:1471-2377, 1471-2377
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Abstract Background The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes. Methods 96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days. Results There was a strong correlation between EDSS and PDDS scores ( ρ  = .783). PDDS and EDSS scores were strongly correlated with Pyramidal ( ρ  = .578 & ρ  = .647, respectively) and Cerebellar ( ρ  = .501 & ρ  = .528, respectively) FS scores as well as 6 MW distance ( ρ  = .704 & ρ  = .805, respectively), MSWS-12 scores ( ρ  = .801 & ρ  = .729, respectively), and accelerometer steps/day ( ρ  = -.740 & ρ  = -.717, respectively). Conclusion This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
AbstractList The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes.BACKGROUNDThe Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes.96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days.METHODS96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days.There was a strong correlation between EDSS and PDDS scores (ρ = .783). PDDS and EDSS scores were strongly correlated with Pyramidal (ρ = .578 &ρ = .647, respectively) and Cerebellar (ρ = .501 &ρ = .528, respectively) FS scores as well as 6 MW distance (ρ = .704 &ρ = .805, respectively), MSWS-12 scores (ρ = .801 &ρ = .729, respectively), and accelerometer steps/day (ρ = -.740 &ρ = -.717, respectively).RESULTSThere was a strong correlation between EDSS and PDDS scores (ρ = .783). PDDS and EDSS scores were strongly correlated with Pyramidal (ρ = .578 &ρ = .647, respectively) and Cerebellar (ρ = .501 &ρ = .528, respectively) FS scores as well as 6 MW distance (ρ = .704 &ρ = .805, respectively), MSWS-12 scores (ρ = .801 &ρ = .729, respectively), and accelerometer steps/day (ρ = -.740 &ρ = -.717, respectively).This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.CONCLUSIONThis study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
Background: The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes. Methods: 96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days. Results: There was a strong correlation between EDSS and PDDS scores ([rho] = .783). PDDS and EDSS scores were strongly correlated with Pyramidal ([rho] = .578 & [rho] = .647, respectively) and Cerebellar ([rho] = .501 & [rho] = .528, respectively) FS scores as well as 6 MW distance ([rho] = .704 & [rho] = .805, respectively), MSWS-12 scores ([rho] = .801 & [rho] = .729, respectively), and accelerometer steps/day ([rho] = -.740 & [rho] = -.717, respectively). Conclusion: This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
Doc number: 37 Abstract Background: The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes. Methods: 96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days. Results: There was a strong correlation between EDSS and PDDS scores (ρ = .783). PDDS and EDSS scores were strongly correlated with Pyramidal (ρ = .578 & ρ = .647, respectively) and Cerebellar (ρ = .501 & ρ = .528, respectively) FS scores as well as 6 MW distance (ρ = .704 & ρ = .805, respectively), MSWS-12 scores (ρ = .801 & ρ = .729, respectively), and accelerometer steps/day (ρ = -.740 & ρ = -.717, respectively). Conclusion: This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
Background The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes. Methods 96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days. Results There was a strong correlation between EDSS and PDDS scores ( ρ  = .783). PDDS and EDSS scores were strongly correlated with Pyramidal ( ρ  = .578 & ρ  = .647, respectively) and Cerebellar ( ρ  = .501 & ρ  = .528, respectively) FS scores as well as 6 MW distance ( ρ  = .704 & ρ  = .805, respectively), MSWS-12 scores ( ρ  = .801 & ρ  = .729, respectively), and accelerometer steps/day ( ρ  = -.740 & ρ  = -.717, respectively). Conclusion This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes. 96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days. There was a strong correlation between EDSS and PDDS scores ([rho] = .783). PDDS and EDSS scores were strongly correlated with Pyramidal ([rho] = .578 & [rho] = .647, respectively) and Cerebellar ([rho] = .501 & [rho] = .528, respectively) FS scores as well as 6 MW distance ([rho] = .704 & [rho] = .805, respectively), MSWS-12 scores ([rho] = .801 & [rho] = .729, respectively), and accelerometer steps/day ([rho] = -.740 & [rho] = -.717, respectively). This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes. 96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days. There was a strong correlation between EDSS and PDDS scores (ρ = .783). PDDS and EDSS scores were strongly correlated with Pyramidal (ρ = .578 &ρ = .647, respectively) and Cerebellar (ρ = .501 &ρ = .528, respectively) FS scores as well as 6 MW distance (ρ = .704 &ρ = .805, respectively), MSWS-12 scores (ρ = .801 &ρ = .729, respectively), and accelerometer steps/day (ρ = -.740 &ρ = -.717, respectively). This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
ArticleNumber 37
Audience Academic
Author Learmonth, Yvonne C
Pula, John H
Sandroff, Brian M
Cadavid, Diego
Motl, Robert W
AuthorAffiliation 2 College of Medicine, University of Illinois at Peoria, Peoria, IL, USA
3 Illinois Neurological Institute, Peoria, IL, USA
4 Biogen Idec, Weston, MA, USA
1 Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA
AuthorAffiliation_xml – name: 4 Biogen Idec, Weston, MA, USA
– name: 2 College of Medicine, University of Illinois at Peoria, Peoria, IL, USA
– name: 3 Illinois Neurological Institute, Peoria, IL, USA
– name: 1 Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA
Author_xml – sequence: 1
  givenname: Yvonne C
  surname: Learmonth
  fullname: Learmonth, Yvonne C
  organization: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign
– sequence: 2
  givenname: Robert W
  surname: Motl
  fullname: Motl, Robert W
  email: robmotl@illinois.edu
  organization: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign
– sequence: 3
  givenname: Brian M
  surname: Sandroff
  fullname: Sandroff, Brian M
  organization: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign
– sequence: 4
  givenname: John H
  surname: Pula
  fullname: Pula, John H
  organization: College of Medicine, University of Illinois at Peoria, Illinois Neurological Institute
– sequence: 5
  givenname: Diego
  surname: Cadavid
  fullname: Cadavid, Diego
  organization: Biogen Idec
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23617555$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Learmonth et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
COPYRIGHT 2013 BioMed Central Ltd.
2013 Learmonth et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2013 Learmonth et al.; licensee BioMed Central Ltd. 2013 Learmonth et al.; licensee BioMed Central Ltd.
Copyright_xml – notice: Learmonth et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: COPYRIGHT 2013 BioMed Central Ltd.
– notice: 2013 Learmonth et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2013 Learmonth et al.; licensee BioMed Central Ltd. 2013 Learmonth et al.; licensee BioMed Central Ltd.
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Issue 1
Keywords Multiple Sclerosis
Pace Auditory Serial Additional Test
Expand Disability Status Scale Score
Symbol Digit Modality Test
Expand Disability Status Scale
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Snippet Background The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there...
The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited...
Background The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there...
Doc number: 37 Abstract Background: The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple...
Background: The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there...
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StartPage 37
SubjectTerms Adult
Aged
Care and treatment
Demyelinating diseases
Disability Evaluation
Exercise Test
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple sclerosis
Multiple Sclerosis - diagnosis
Multiple Sclerosis - physiopathology
Neurochemistry
Neurology
Neuropsychological Tests
Neurosurgery
Patient Outcome Assessment
Quality of life
Reproducibility of Results
Research Article
Severity of Illness Index
Studies
Validity
Walking
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Title Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis
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