Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability

R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on chromatin. Intriguingly, changes in R-loop dynamics have also been associated with DNA damage accumulation and genome instability; however, t...

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Veröffentlicht in:	Molecular cell Jg. 56; H. 6; S. 777
Hauptverfasser:	Sollier, Julie, Stork, Caroline Townsend, García-Rubio, María L, Paulsen, Renee D, Aguilera, Andrés, Cimprich, Karlene A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.12.2014
Schlagworte:	DNA Damage DNA Repair DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endonucleases - genetics Endonucleases - metabolism Genome, Human Genomic Instability HeLa Cells Humans Nuclear Proteins - genetics Nuclear Proteins - metabolism RNA Replicase - genetics RNA Replicase - metabolism RNA, Fungal - genetics RNA, Fungal - metabolism Saccharomyces cerevisiae - genetics Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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