BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

ERK signaling requires RAS-induced RAF dimerization and is limited by feedback. Activated BRAF mutants evade feedback inhibition of RAS by either of two mechanisms. BRAF V600 mutants are activated monomers when RAS activity is low; all other activating BRAF mutants function as constitutive RAS-indep...

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Vydáno v:	Cancer cell Ročník 28; číslo 3; s. 370
Hlavní autoři:	Yao, Zhan, Torres, Neilawattie M, Tao, Anthony, Gao, Yijun, Luo, Lusong, Li, Qi, de Stanchina, Elisa, Abdel-Wahab, Omar, Solit, David B, Poulikakos, Poulikos I, Rosen, Neal
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 14.09.2015
Témata:	Cell Line, Tumor Dimerization Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Humans MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics Mutation - genetics Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics ras Proteins - genetics
ISSN:	1878-3686, 1878-3686
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