The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

Key Points Monomeric ubiquitin is relatively stable; however, it appears to be degraded by the proteasome following its own ubiquitylation, which is mediated by the thyroid receptor-interacting protein 12 (TRIP12) ligase. Ubiquitin is also degraded through two other mechanisms: along with the target...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Molecular cell biology Jg. 12; H. 9; S. 605 - 620
Hauptverfasser:	Weissman, Allan M., Shabek, Nitzan, Ciechanover, Aaron
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.09.2011 Nature Publishing Group
Schlagworte:	631/337/474/2085 631/337/474/582 631/45/612/645 Animals Biochemistry Biomedical and Life Sciences Cancer Research Cell Biology Cell cycle Cellular proteins Developmental Biology Enzymes Food Chain Humans Life Sciences Models, Biological Physiological aspects Proteasome Endopeptidase Complex - metabolism Proteasome Endopeptidase Complex - physiology Protein Processing, Post-Translational - physiology Proteins review-article Stem Cells Ubiquitin Ubiquitin - metabolism Ubiquitin-proteasome system Ubiquitination - physiology Wit and Humor as Topic United States Israel
ISSN:	1471-0072, 1471-0080, 1471-0080
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!