Research progress on related mechanisms of uric acid activating NLRP3 inflammasome in chronic kidney disease

Hyperuricemia is an independent risk factor for the progression of chronic kidney disease. High levels of uric acid can lead to a series of pathological conditions, such as gout, urinary stones, inflammation, and uric acid nephropathy. There is a close relationship between uric acid and the NLRP3 in...

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Veröffentlicht in:	Renal failure Jg. 44; H. 1; S. 615 - 624
Hauptverfasser:	Wang, Miao, Lin, Xin, Yang, Xiaoming, Yang, Yanlang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Taylor & Francis 01.12.2022 Taylor & Francis Ltd Taylor & Francis Group
Schlagworte:	Caspase-1 Cell activation Cell death Cell membranes Crystals Endoplasmic reticulum Golgi apparatus Gout Humans Hyperuricemia Hyperuricemia - complications Inflammasomes Inflammasomes - metabolism Inflammation Interleukin 18 Interleukin-1beta - metabolism Kidney diseases Lysis Mitochondria Molecular modelling Nephropathy NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasomes organelle oxidative stress Renal Insufficiency, Chronic - etiology Review Risk factors State-of-the-Art Review Uric acid Uric Acid - metabolism NLRP3 inflammasomes Uric acid organelle oxidative stress
ISSN:	0886-022X, 1525-6049, 1525-6049
Online-Zugang:	Volltext
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