Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination activates an error-free pathway, elusive in mammals, enabling damage bypass by template switching. Fork reversal is driven...

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Bibliographic Details
Published in:	Molecular cell Vol. 67; no. 5; p. 882
Main Authors:	Vujanovic, Marko, Krietsch, Jana, Raso, Maria Chiara, Terraneo, Nastassja, Zellweger, Ralph, Schmid, Jonas A, Taglialatela, Angelo, Huang, Jen-Wei, Holland, Cory L, Zwicky, Katharina, Herrador, Raquel, Jacobs, Heinz, Cortez, David, Ciccia, Alberto, Penengo, Lorenza, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	United States 07.09.2017
Subjects:	Animals CRISPR-Cas Systems DNA Damage DNA Helicases - genetics DNA Helicases - metabolism DNA Replication DNA, Neoplasm - biosynthesis DNA, Neoplasm - genetics DNA, Neoplasm - ultrastructure HCT116 Cells HEK293 Cells Humans Kinetics Mice Mutation Neoplasms - enzymology Neoplasms - genetics Neoplasms - ultrastructure Polyubiquitin - metabolism Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Replication Origin RNA Interference Transfection Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism Ubiquitination DNA damage tolerance cancer chemotherapeutics ZRANB3 DNA translocase PCNA ubiquitination single-molecule approaches electron microscopy in vivo postreplication repair replication fork reversal replication fork progression
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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