Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning

Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importan...

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Vydáno v:Frontiers in physiology Ročník 11; s. 71
Hlavní autoři: Arc-Chagnaud, Coralie, Py, Guillaume, Fovet, Théo, Roumanille, Rémi, Demangel, Rémi, Pagano, Allan F., Delobel, Pierre, Blanc, Stéphane, Jasmin, Bernard J., Blottner, Dieter, Salanova, Michele, Gomez-Cabrera, Mari-Carmen, Viña, José, Brioche, Thomas, Chopard, Angèle
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers 12.02.2020
Frontiers Media S.A
Témata:
antioxidants
cell signaling
Human health and pathology
inactivity
Life Sciences
muscle wasting
oxidative stress
Physiology
antioxidants
muscle wasting
oxidative stress
cell signaling
inactivity
ISSN:1664-042X, 1664-042X
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Shrnutí:Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning.
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This article was submitted to Environmental, Aviation and Space Physiology, a section of the journal Frontiers in Physiology
Reviewed by: Satoshi Iwase, Aichi Medical University, Japan; Laurence Stevens, Lille University of Science and Technology, France
Edited by: Marc-Antoine Custaud, Université d’Angers, France
These authors have contributed equally to this work
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2020.00071