Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning
Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importan...
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| Veröffentlicht in: | Frontiers in physiology Jg. 11; S. 71 |
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| Sprache: | Englisch |
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12.02.2020
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| Abstract | Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning. |
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| AbstractList | Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning. Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning.Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning. Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 mu g of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning. |
| Author | Jasmin, Bernard J. Viña, José Brioche, Thomas Delobel, Pierre Blottner, Dieter Chopard, Angèle Salanova, Michele Py, Guillaume Demangel, Rémi Roumanille, Rémi Arc-Chagnaud, Coralie Pagano, Allan F. Gomez-Cabrera, Mari-Carmen Blanc, Stéphane Fovet, Théo |
| AuthorAffiliation | 6 Berlin Center for Space Medicine, Integrative Neuroanatomy, Charité Universitätsmedizin Berlin , Berlin , Germany 5 IPHC, CNRS, Université de Strasbourg , Strasbourg , France 1 DMEM, Université Montpellier, INRAE , Montpellier , France 4 Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa , Ottawa, ON , Canada 3 Faculté des Sciences du Sport, Mitochondries, Stress Oxydant et Protection Musculaire, Université de Strasbourg , Strasbourg , France 2 Freshage Research Group, Department of Physiology, Faculty of Medicine, CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, University of Valencia , Valencia , Spain |
| AuthorAffiliation_xml | – name: 2 Freshage Research Group, Department of Physiology, Faculty of Medicine, CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, University of Valencia , Valencia , Spain – name: 6 Berlin Center for Space Medicine, Integrative Neuroanatomy, Charité Universitätsmedizin Berlin , Berlin , Germany – name: 3 Faculté des Sciences du Sport, Mitochondries, Stress Oxydant et Protection Musculaire, Université de Strasbourg , Strasbourg , France – name: 5 IPHC, CNRS, Université de Strasbourg , Strasbourg , France – name: 1 DMEM, Université Montpellier, INRAE , Montpellier , France – name: 4 Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa , Ottawa, ON , Canada |
| Author_xml | – sequence: 1 givenname: Coralie surname: Arc-Chagnaud fullname: Arc-Chagnaud, Coralie – sequence: 2 givenname: Guillaume surname: Py fullname: Py, Guillaume – sequence: 3 givenname: Théo surname: Fovet fullname: Fovet, Théo – sequence: 4 givenname: Rémi surname: Roumanille fullname: Roumanille, Rémi – sequence: 5 givenname: Rémi surname: Demangel fullname: Demangel, Rémi – sequence: 6 givenname: Allan F. surname: Pagano fullname: Pagano, Allan F. – sequence: 7 givenname: Pierre surname: Delobel fullname: Delobel, Pierre – sequence: 8 givenname: Stéphane surname: Blanc fullname: Blanc, Stéphane – sequence: 9 givenname: Bernard J. surname: Jasmin fullname: Jasmin, Bernard J. – sequence: 10 givenname: Dieter surname: Blottner fullname: Blottner, Dieter – sequence: 11 givenname: Michele surname: Salanova fullname: Salanova, Michele – sequence: 12 givenname: Mari-Carmen surname: Gomez-Cabrera fullname: Gomez-Cabrera, Mari-Carmen – sequence: 13 givenname: José surname: Viña fullname: Viña, José – sequence: 14 givenname: Thomas surname: Brioche fullname: Brioche, Thomas – sequence: 15 givenname: Angèle surname: Chopard fullname: Chopard, Angèle |
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| ContentType | Journal Article |
| Copyright | Copyright © 2020 Arc-Chagnaud, Py, Fovet, Roumanille, Demangel, Pagano, Delobel, Blanc, Jasmin, Blottner, Salanova, Gomez-Cabrera, Viña, Brioche and Chopard. licence_http://creativecommons.org/publicdomain/zero Copyright © 2020 Arc-Chagnaud, Py, Fovet, Roumanille, Demangel, Pagano, Delobel, Blanc, Jasmin, Blottner, Salanova, Gomez-Cabrera, Viña, Brioche and Chopard. 2020 Arc-Chagnaud, Py, Fovet, Roumanille, Demangel, Pagano, Delobel, Blanc, Jasmin, Blottner, Salanova, Gomez-Cabrera, Viña, Brioche and Chopard |
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| Keywords | antioxidants muscle wasting oxidative stress cell signaling inactivity |
| Language | English |
| License | Copyright © 2020 Arc-Chagnaud, Py, Fovet, Roumanille, Demangel, Pagano, Delobel, Blanc, Jasmin, Blottner, Salanova, Gomez-Cabrera, Viña, Brioche and Chopard. licence_http://creativecommons.org/publicdomain/zero/: http://creativecommons.org/publicdomain/zero This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Environmental, Aviation and Space Physiology, a section of the journal Frontiers in Physiology Reviewed by: Satoshi Iwase, Aichi Medical University, Japan; Laurence Stevens, Lille University of Science and Technology, France Edited by: Marc-Antoine Custaud, Université d’Angers, France These authors have contributed equally to this work |
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| Title | Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning |
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