Progress and barriers for the control of diarrhoeal disease

Discovery of intestinal sodium-glucose transport was the basis for development of oral rehydration solution, and was hailed as potentially the most important medical advance of the 20th century. Before widespread use of oral rehydration solution, treatment for diarrhoea was restricted to intravenous...

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Bibliographic Details
Published in:The Lancet (British edition) Vol. 376; no. 9734; pp. 63 - 67
Main Authors: Santosham, Mathuram, Chandran, Aruna, Fitzwater, Sean, Fischer-Walker, Christa, Baqui, Abdullah H, Black, Robert
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 03.07.2010
Elsevier
Elsevier Limited
Subjects:
Acute Disease
Biological and medical sciences
Child, Preschool
Children & youth
Dehydration
Developing Countries
Diarrhea
Diarrhea - microbiology
Diarrhea - mortality
Diarrhea - therapy
Fluid Therapy
General aspects
Humans
Infant
Internal Medicine
LDCs
Medical sciences
Mortality
Osmolar Concentration
Rehydration Solutions - chemistry
Zinc - analysis
Medicine
Accessibility
Disease
Surveillance
Check
Diarrhea
Digestive diseases
Intestinal disease
Barrier
Care
ISSN:0140-6736, 1474-547X, 1474-547X
Online Access:Get full text
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Summary:Discovery of intestinal sodium-glucose transport was the basis for development of oral rehydration solution, and was hailed as potentially the most important medical advance of the 20th century. Before widespread use of oral rehydration solution, treatment for diarrhoea was restricted to intravenous fluid replacement, for which patients had to go to a health-care facility to access appropriate equipment. These facilities were usually neither available nor reasonable to use in the resource-poor settings most affected by diarrhoea. Use of oral rehydration solution has stagnated, despite being effective, inexpensive, and widely available. Thus, diarrhoea continues to be a leading cause of child death with consistent mortality rates during the past 5 years. New methods for prevention, management, and treatment of diarrhoea—including an improved oral rehydration formulation, zinc supplementation, and rotavirus vaccines—make now the time to revitalise efforts to reduce diarrhoea mortality worldwide.
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ISSN:0140-6736
1474-547X
1474-547X
DOI:10.1016/S0140-6736(10)60356-X