Bone marrow mesenchymal stem cell-derived exosomal miR-30e-5p ameliorates high-glucose induced renal proximal tubular cell pyroptosis by inhibiting ELAVL1

The rapid increase in the prevalence of diabetes has resulted in more cases of diabetic kidney disease (DKD). Treatment with bone marrow mesenchymal stem cells (BMSCs) may represent an alternative strategy to manage DKD. HK-2 cells were treated with 30 mM high glucose (HG). Bone marrow MSC-derived e...

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Veröffentlicht in:	Renal failure Jg. 45; H. 1; S. 2177082
Hauptverfasser:	Lv, Jia, Hao, Ya-Ning, Wang, Xiao-Pei, Lu, Wan-Hong, Xie, Li-Yi, Niu, Dan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Taylor & Francis 01.12.2023 Taylor & Francis Ltd Taylor & Francis Group
Schlagworte:	Bone marrow bone marrow mesenchymal stem cells Caspase-1 Caspases - metabolism Caspases - pharmacology Cell Line Clinical Study Cytotoxicity Diabetes mellitus diabetic kidney disease ELAV-Like Protein 1 - genetics Enzyme-linked immunosorbent assay exosome Exosomes Flow cytometry Glucose - metabolism Glucose - pharmacology Humans IL-1β Interleukin 18 Interleukin-18 - metabolism Interleukin-18 - pharmacology Kidney diseases Kidney Tubules, Proximal - cytology L-Lactate dehydrogenase Mesenchymal stem cells Mesenchymal Stem Cells - metabolism MicroRNAs - genetics miR-30e-5p Overexpression Pyroptosis Reporter gene RNA-binding protein diabetic kidney disease Pyroptosis bone marrow mesenchymal stem cells exosome miR-30e-5p
ISSN:	0886-022X, 1525-6049, 1525-6049
Online-Zugang:	Volltext
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