Ketone body utilization drives tumor growth and metastasis

We have previously proposed that catabolic fibroblasts generate mitochondrial fuels (such as ketone bodies) to promote the anabolic growth of human cancer cells and their metastasic dissemination. We have termed this new paradigm "two-compartment tumor metabolism." Here, we further tested...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 11; no. 21; pp. 3964 - 3971
Main Authors:	Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Whitaker-Menezes, Diana, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.11.2012 Landes Bioscience
Subjects:	3-hydroxy-butyrate ACAT isoforms Acetyl-CoA C-Acetyltransferase - metabolism Animals Autophagy BDH1 Binding Biology Bioscience Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium Cancer cancer metabolism Caveolin 1 - genetics Caveolin 1 - metabolism Cell Cell Line Cell Movement Cell Proliferation Coculture Techniques Coenzyme A-Transferases - metabolism Cycle Female HMGCS2 Humans Hydroxymethylglutaryl-CoA Synthase - metabolism Ketone Bodies - metabolism ketone body Landes MCF-7 Cells metastasis Mice Mice, Nude Mitochondrial Turnover Neovascularization, Pathologic Organogenesis OXCT isoforms Proteins Sterol O-Acyltransferase - metabolism Sterol O-Acyltransferase 2 Transplantation, Heterologous tumor growth
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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