Ketone body utilization drives tumor growth and metastasis

We have previously proposed that catabolic fibroblasts generate mitochondrial fuels (such as ketone bodies) to promote the anabolic growth of human cancer cells and their metastasic dissemination. We have termed this new paradigm "two-compartment tumor metabolism." Here, we further tested...

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Vydáno v:	Cell cycle (Georgetown, Tex.) Ročník 11; číslo 21; s. 3964 - 3971
Hlavní autoři:	Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Whitaker-Menezes, Diana, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Taylor & Francis 01.11.2012 Landes Bioscience
Témata:	3-hydroxy-butyrate ACAT isoforms Acetyl-CoA C-Acetyltransferase - metabolism Animals Autophagy BDH1 Binding Biology Bioscience Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium Cancer cancer metabolism Caveolin 1 - genetics Caveolin 1 - metabolism Cell Cell Line Cell Movement Cell Proliferation Coculture Techniques Coenzyme A-Transferases - metabolism Cycle Female HMGCS2 Humans Hydroxymethylglutaryl-CoA Synthase - metabolism Ketone Bodies - metabolism ketone body Landes MCF-7 Cells metastasis Mice Mice, Nude Mitochondrial Turnover Neovascularization, Pathologic Organogenesis OXCT isoforms Proteins Sterol O-Acyltransferase - metabolism Sterol O-Acyltransferase 2 Transplantation, Heterologous tumor growth
ISSN:	1538-4101, 1551-4005, 1551-4005
On-line přístup:	Získat plný text
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