NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

Emerging evidence suggests that astrocyte loss is one of the most important pathological features in the hippocampus of patients with major depressive disorder (MDD) and depressive mice. Pyroptosis is a recently discovered form of programmed cell death depending on Caspase-gasdermin D (Casp-GSDMD),...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	JCI insight Ročník 6; číslo 23
Hlavní autori:	Li, Shanshan, Sun, Yiming, Song, Mengmeng, Song, Yuting, Fang, Yinquan, Zhang, Qingyu, Li, Xueting, Song, Nanshan, Ding, Jianhua, Lu, Ming, Hu, Gang
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States American Society for Clinical Investigation 08.12.2021 American Society for Clinical investigation
Predmet:	Animals Apoptosis Astrocytes - metabolism Behavior Caspase 1 - metabolism Caspase-1 Cell death Depression - genetics Disease Disease Models, Animal Hippocampus Humans Inflammasomes Inflammation Mental depression Mental disorders Mice NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pathogenesis Proteins Pyroptosis Pyroptosis - immunology Serotonin uptake inhibitors Signal transduction Depression Inflammation Psychiatric diseases Cytokines
ISSN:	2379-3708, 2379-3708
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!