NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

Emerging evidence suggests that astrocyte loss is one of the most important pathological features in the hippocampus of patients with major depressive disorder (MDD) and depressive mice. Pyroptosis is a recently discovered form of programmed cell death depending on Caspase-gasdermin D (Casp-GSDMD),...

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Veröffentlicht in:	JCI insight Jg. 6; H. 23
Hauptverfasser:	Li, Shanshan, Sun, Yiming, Song, Mengmeng, Song, Yuting, Fang, Yinquan, Zhang, Qingyu, Li, Xueting, Song, Nanshan, Ding, Jianhua, Lu, Ming, Hu, Gang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Society for Clinical Investigation 08.12.2021 American Society for Clinical investigation
Schlagworte:	Animals Apoptosis Astrocytes - metabolism Behavior Caspase 1 - metabolism Caspase-1 Cell death Depression - genetics Disease Disease Models, Animal Hippocampus Humans Inflammasomes Inflammation Mental depression Mental disorders Mice NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pathogenesis Proteins Pyroptosis Pyroptosis - immunology Serotonin uptake inhibitors Signal transduction Depression Inflammation Psychiatric diseases Cytokines
ISSN:	2379-3708, 2379-3708
Online-Zugang:	Volltext
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