Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels
Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects. The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increase...
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| Vydáno v: | Journal of allergy and clinical immunology Ročník 123; číslo 3; s. 680 - 686 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
New York, NY
Mosby, Inc
01.03.2009
Elsevier Elsevier Limited |
| Témata: | |
| ISSN: | 0091-6749, 1097-6825, 1097-6825 |
| On-line přístup: | Získat plný text |
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| Abstract | Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects.
The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens.
Subjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection of
KIT mutations.
Forty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. A
KIT mutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders.
The concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease. |
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| AbstractList | Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects.BACKGROUNDAnaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects.The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens.OBJECTIVEThe incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens.Subjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection of KIT mutations.METHODSSubjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection of KIT mutations.Forty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. A KIT mutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders.RESULTSForty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. A KIT mutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders.The concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease.CONCLUSIONThe concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease. Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects. The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens. Subjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection of KIT mutations. Forty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. A KIT mutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders. The concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease. Background Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects. Objective The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens. Methods Subjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection of KIT mutations. Results Forty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. A KIT mutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders. Conclusion The concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease. Background Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects. Objective The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens. Methods Subjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection ofKITmutations. Results Forty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. AKITmutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders. Conclusion The concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease. Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects. The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens. Subjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection of KIT mutations. Forty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. A KIT mutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders. The concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease. |
| Author | Pizzolo, Giovanni Dal Fior, Daniela Bonetto, Chiara Zanotti, Roberta Castellani, Luca Dama, Annarita Bonadonna, Patrizia Passalacqua, Giovanni Chilosi, Marco Colarossi, Sabrina Martinelli, Giovanni Perbellini, Omar Senna, Gianenrico Caruso, Beatrice Frattini, Francesco |
| Author_xml | – sequence: 1 givenname: Patrizia surname: Bonadonna fullname: Bonadonna, Patrizia organization: Allergy Unit, Verona General Hospital, Verona, Italy – sequence: 2 givenname: Omar surname: Perbellini fullname: Perbellini, Omar organization: Department of Clinical and Experimental Medicine, Haematology Section, University of Verona, Verona, Italy – sequence: 3 givenname: Giovanni surname: Passalacqua fullname: Passalacqua, Giovanni email: passalacqua@unige.it organization: Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, Italy – sequence: 4 givenname: Beatrice surname: Caruso fullname: Caruso, Beatrice organization: Clinical Chemistry and Haematology, Verona General Hospital, Verona, Italy – sequence: 5 givenname: Sabrina surname: Colarossi fullname: Colarossi, Sabrina organization: Department of Haematology/Oncology, L. and A. Seragnoli, University of Bologna, Bologna, Italy – sequence: 6 givenname: Daniela surname: Dal Fior fullname: Dal Fior, Daniela organization: Department of Pathology, University of Verona, Verona, Italy – sequence: 7 givenname: Luca surname: Castellani fullname: Castellani, Luca organization: Department of Dermatology, Santa Maria del Carmine Hospital, Rovereto, Italy – sequence: 8 givenname: Chiara surname: Bonetto fullname: Bonetto, Chiara organization: Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy – sequence: 9 givenname: Francesco surname: Frattini fullname: Frattini, Francesco organization: Department of Clinical and Experimental Medicine, Haematology Section, University of Verona, Verona, Italy – sequence: 10 givenname: Annarita surname: Dama fullname: Dama, Annarita organization: Allergy Unit, Verona General Hospital, Verona, Italy – sequence: 11 givenname: Giovanni surname: Martinelli fullname: Martinelli, Giovanni organization: Department of Haematology/Oncology, L. and A. Seragnoli, University of Bologna, Bologna, Italy – sequence: 12 givenname: Marco surname: Chilosi fullname: Chilosi, Marco organization: Department of Pathology, University of Verona, Verona, Italy – sequence: 13 givenname: Gianenrico surname: Senna fullname: Senna, Gianenrico organization: Allergy Unit, Verona General Hospital, Verona, Italy – sequence: 14 givenname: Giovanni surname: Pizzolo fullname: Pizzolo, Giovanni organization: Department of Clinical and Experimental Medicine, Haematology Section, University of Verona, Verona, Italy – sequence: 15 givenname: Roberta surname: Zanotti fullname: Zanotti, Roberta organization: Department of Clinical and Experimental Medicine, Haematology Section, University of Verona, Verona, Italy |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21299257$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19135713$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jaci.2003.10.013 10.1046/j.1365-2133.1999.03214.x 10.4049/jimmunol.170.11.5667 10.1016/S0145-2126(01)00041-8 10.1159/000096442 10.1016/j.jaci.2004.02.045 10.1016/0091-6749(83)90630-9 10.1016/S0091-6749(97)70188-X 10.1159/000059404 10.1056/NEJM198706253162603 10.1046/j.1365-2222.2003.01755.x 10.1182/blood.V87.8.3117.bloodjournal8783117 10.1038/ng0396-312 10.3109/02770906609106941 10.1016/S0091-6749(97)70314-2 10.1159/000048188 10.1016/S0140-6736(00)03647-3 10.1111/j.1365-2222.2007.02804.x 10.1016/j.jaci.2003.12.591 10.1111/j.1365-2796.1993.tb00984.x 10.1016/j.jaci.2007.10.014 10.1159/000101711 10.2353/jmoldx.2006.060022 10.1182/blood-2006-06-028100 10.1111/j.1398-9995.2005.00963.x 10.1073/pnas.92.23.10560 10.1111/j.1365-2362.2007.01807.x 10.1111/j.1398-9995.2007.01569.x 10.1097/01.all.0000235903.10548.63 10.1097/01.all.0000136756.20701.f8 10.1016/S0145-2126(01)00028-5 10.1016/S0140-6736(00)04677-8 |
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| References | Nagata, Worobec, Oh, Chowdhury, Tannenbaum, Suzuki (bib3) 1995; 92 Krishna, Fearby, Annila, Frew (bib29) 2001; 357 Valent, Sperr, Schwartz, Horny (bib34) 2004; 114 Muller, Horat, Wuthrich, Conroy, Reisman (bib11) 1983; 72 Sperr, Jordan, Fiegl, Escribano, Bellas, Dirnhofer (bib30) 2002; 128 Valent, Horny, Li, Longley, Metcalfe, Parwaresch (bib2) 2001 Longley, Reguera, Ma (bib25) 2001; 25 Kors, van Doormaal, de Monchy (bib10) 1993; 233 Piao, Bernstein (bib1) 1996; 87 Sonneck, Florian, Müllauer, Wimazal, Födinger, Sperr (bib5) 2007; 142 Kucharewicz, Bodzenta-Lukaszyk, Szymanski, Mroczko, Szmitkowski (bib32) 2007; 17 Akin, Scott, Kocabas, Kushnir-Sukhov, Brittain, Noel (bib6) 2007; 110 Brockow, Jofer, Behrendt, Ring (bib28) 2008; 63 Rueff, Placzek, Przybilla (bib19) 2006; 6 Longley, Tyrrell, Lu, Ma, Langley, Ding (bib4) 1996; 12 Schwartz, Min, Ren, Xia, Hu, Zhao (bib16) 2003; 170 de Olano, de la Hoz Caballer, Núñez López, Sanchez Munoz, Cuevas Augustin, Diguez (bib27) 2007; 37 Akin (bib26) 2006; 8 Johansson, Bieber, Dahl, Friedman, Lanier, Lockey (bib22) 2004; 113 Castells, Austen (bib8) 2002; 127 Sperr, Escribano, Jordan, Schernthaner, Kundi, Horny (bib24) 2001; 25 Biedermann, Rueff, Sander, Przybilla (bib14) 1999; 141 Schwartz, Metcalfe, Miller, Earl, Sullivan (bib17) 1987; 316 Dubois (bib31) 2004; 4 Bilò, Rueff, Mosbech, Bonifazi, Oude-Elberink (bib20) 2005; 60 (bib23) 1993; 48 Bonadonna, Zanotti, Caruso, Castellani, Perbellini, Colarossi (bib33) 2008; 121 (bib21) 1966; 3 Horny, Sotlar, Valent (bib7) 2007; 74 Oude Elberink, de Monchy, Kors, van Doormaal, Dubois (bib12) 1997; 99 Fricker, Helbling, Schwartz, Müller (bib18) 1997; 100 Ludolph-Hauser, Rueff, Fries, Schopf, Przybilla (bib13) 2001; 357 Valent, Akin, Escribano, Fodinger, Hartman, Brockow (bib9) 2007; 37 Kränke, Sturm, Aberer (bib35) 2004; 113 Haeberli, Bronnimann, Hunziker, Muller (bib15) 2003; 33 Bilò (10.1016/j.jaci.2008.11.018_bib20) 2005; 60 Sperr (10.1016/j.jaci.2008.11.018_bib24) 2001; 25 Kränke (10.1016/j.jaci.2008.11.018_bib35) 2004; 113 Schwartz (10.1016/j.jaci.2008.11.018_bib17) 1987; 316 Castells (10.1016/j.jaci.2008.11.018_bib8) 2002; 127 Krishna (10.1016/j.jaci.2008.11.018_bib29) 2001; 357 Rueff (10.1016/j.jaci.2008.11.018_bib19) 2006; 6 Dubois (10.1016/j.jaci.2008.11.018_bib31) 2004; 4 Nagata (10.1016/j.jaci.2008.11.018_bib3) 1995; 92 Horny (10.1016/j.jaci.2008.11.018_bib7) 2007; 74 Akin (10.1016/j.jaci.2008.11.018_bib6) 2007; 110 Longley (10.1016/j.jaci.2008.11.018_bib25) 2001; 25 Fricker (10.1016/j.jaci.2008.11.018_bib18) 1997; 100 Piao (10.1016/j.jaci.2008.11.018_bib1) 1996; 87 Sperr (10.1016/j.jaci.2008.11.018_bib30) 2002; 128 de Olano (10.1016/j.jaci.2008.11.018_bib27) 2007; 37 Muller (10.1016/j.jaci.2008.11.018_bib11) 1983; 72 Brockow (10.1016/j.jaci.2008.11.018_bib28) 2008; 63 Valent (10.1016/j.jaci.2008.11.018_bib2) 2001 Haeberli (10.1016/j.jaci.2008.11.018_bib15) 2003; 33 Ludolph-Hauser (10.1016/j.jaci.2008.11.018_bib13) 2001; 357 Akin (10.1016/j.jaci.2008.11.018_bib26) 2006; 8 Sonneck (10.1016/j.jaci.2008.11.018_bib5) 2007; 142 (10.1016/j.jaci.2008.11.018_bib23) 1993; 48 Valent (10.1016/j.jaci.2008.11.018_bib9) 2007; 37 Johansson (10.1016/j.jaci.2008.11.018_bib22) 2004; 113 Oude Elberink (10.1016/j.jaci.2008.11.018_bib12) 1997; 99 Schwartz (10.1016/j.jaci.2008.11.018_bib16) 2003; 170 Longley (10.1016/j.jaci.2008.11.018_bib4) 1996; 12 Bonadonna (10.1016/j.jaci.2008.11.018_bib33) 2008; 121 Valent (10.1016/j.jaci.2008.11.018_bib34) 2004; 114 Biedermann (10.1016/j.jaci.2008.11.018_bib14) 1999; 141 Kucharewicz (10.1016/j.jaci.2008.11.018_bib32) 2007; 17 Kors (10.1016/j.jaci.2008.11.018_bib10) 1993; 233 (10.1016/j.jaci.2008.11.018_bib21) 1966; 3 19281912 - J Allergy Clin Immunol. 2009 Mar;123(3):687-8 |
| References_xml | – volume: 3 start-page: 331 year: 1966 end-page: 333 ident: bib21 article-title: Mueller HL Diagnosis and treatment of insect sensitivity publication-title: J Asthma Res – volume: 37 start-page: 435 year: 2007 end-page: 453 ident: bib9 article-title: Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria publication-title: Eur J Clin Invest – volume: 60 start-page: 1339 year: 2005 end-page: 1349 ident: bib20 article-title: EAACI Interest Group on Insect Venom Hypersensitivity. Diagnosis of Hymenoptera venom allergy publication-title: Allergy – volume: 48 start-page: 48 year: 1993 end-page: 82 ident: bib23 article-title: The European Academy of Allergology and Clinical Immunology. Position paper: allergen standardisation and skin tests publication-title: Allergy – volume: 87 start-page: 3117 year: 1996 end-page: 3123 ident: bib1 article-title: A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells publication-title: Blood – volume: 25 start-page: 529 year: 2001 end-page: 536 ident: bib24 article-title: Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis publication-title: Leuk Res – volume: 6 start-page: 284 year: 2006 end-page: 288 ident: bib19 article-title: Mastocytosis and Hymenoptera venom allergy publication-title: Curr Opin Allergy Clin Immunol – volume: 128 start-page: 136 year: 2002 end-page: 141 ident: bib30 article-title: Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of disease publication-title: Int Arch Allergy Immunol – volume: 113 start-page: 832 year: 2004 end-page: 836 ident: bib22 article-title: Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003 publication-title: J Allergy Clin Immunol – start-page: 291 year: 2001 end-page: 302 ident: bib2 article-title: Mastocytosis publication-title: World Health Organization classification of tumours: pathology and genetics in tumours of haematopoietic and lymphoid tissues – volume: 110 start-page: 2331 year: 2007 end-page: 2333 ident: bib6 article-title: Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with “idiopathic” anaphylaxis publication-title: Blood – volume: 316 start-page: 1622 year: 1987 end-page: 1626 ident: bib17 article-title: Tryptase levels as an indicator of mast cell activation in systemic anaphylaxis and mastocytosis publication-title: N Engl J Med – volume: 74 start-page: 121 year: 2007 end-page: 132 ident: bib7 article-title: Mastocytosis: state of the art publication-title: Pathobiology – volume: 12 start-page: 312 year: 1996 end-page: 314 ident: bib4 article-title: Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm publication-title: Nat Genet – volume: 114 start-page: 3 year: 2004 end-page: 11 ident: bib34 article-title: Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms publication-title: J Allergy Clin Immunol – volume: 25 start-page: 571 year: 2001 end-page: 576 ident: bib25 article-title: Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy publication-title: Leuk Res – volume: 357 start-page: 1527 year: 2001 end-page: 1528 ident: bib29 article-title: Hymenoptera stings and serum tryptase publication-title: Lancet – volume: 72 start-page: 685 year: 1983 end-page: 689 ident: bib11 article-title: Anaphylaxis after Hymenoptera stings in three patients with urticaria pigmentosa publication-title: J Allergy Clin Immunol – volume: 8 start-page: 412 year: 2006 end-page: 419 ident: bib26 article-title: Molecular diagnosis of mast cell disorders: a paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology publication-title: J Mol Diagn – volume: 141 start-page: 1110 year: 1999 end-page: 1112 ident: bib14 article-title: Mastocytosis associated with severe wasp sting anaphylaxis detected by elevated serum mast cell tryptase levels publication-title: Br J Dermatol – volume: 37 start-page: 1547 year: 2007 end-page: 1555 ident: bib27 article-title: Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA) publication-title: Clin Exp Allergy – volume: 142 start-page: 158 year: 2007 end-page: 164 ident: bib5 article-title: Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: monoclonal mast cell activation syndrome publication-title: Int Arch Allergy Immunol – volume: 92 start-page: 10560 year: 1995 end-page: 10564 ident: bib3 article-title: Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder publication-title: Proc Natl Acad Sci U S A – volume: 121 start-page: 256 year: 2008 end-page: 257 ident: bib33 article-title: Allergen specific immunotherapy is safe and effective in patients with systemic mastocytosis and Hymenoptera allergy publication-title: J Allergy Clin Immunol – volume: 17 start-page: 65 year: 2007 end-page: 69 ident: bib32 article-title: Basal serum tryptase level correlates with severity of Hymenoptera sting and age publication-title: J Investig Allergol Clin Immunol – volume: 100 start-page: 11 year: 1997 end-page: 15 ident: bib18 article-title: Hymenoptera sting anaphylaxis and urticaria pigmentosa: clinical findings and results of venom immunotherapy in ten patients publication-title: J Allergy Clin Immunol – volume: 99 start-page: 153 year: 1997 end-page: 154 ident: bib12 article-title: Fatal anaphylaxis after a yellow jacket sting, despite venom immunotherapy, in two patients with mastocytosis publication-title: J Allergy Clin Immunol – volume: 357 start-page: 361 year: 2001 end-page: 362 ident: bib13 article-title: Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reaction to Hymenoptera sting publication-title: Lancet – volume: 33 start-page: 1216 year: 2003 end-page: 1220 ident: bib15 article-title: Elevated basal serum tryptase and Hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy publication-title: Clin Exp Allergy – volume: 127 start-page: 147 year: 2002 end-page: 152 ident: bib8 article-title: Mastocytosis: mediator-related signs and symptoms publication-title: Int Arch Allergy Immunol – volume: 63 start-page: 226 year: 2008 end-page: 232 ident: bib28 article-title: Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients publication-title: Allergy – volume: 170 start-page: 5667 year: 2003 end-page: 5673 ident: bib16 article-title: Tryptase precursors are preferentially and spontaneously released, whereas mature tryptase is retained by HMC-1 cells, Mono-Mac-6 cells, and human skin-derived mast cells publication-title: J Immunol – volume: 4 start-page: 291 year: 2004 end-page: 295 ident: bib31 article-title: Mastocytosis and Hymenoptera allergy publication-title: Curr Opin Allergy Clin Immunol – volume: 113 start-page: 180 year: 2004 end-page: 181 ident: bib35 article-title: Negative venom skin test results and mastocytosis publication-title: J Allergy Clin Immunol – volume: 233 start-page: 255 year: 1993 end-page: 258 ident: bib10 article-title: Anaphylactoid shock following Hymenoptera sting as a presenting symptom of systemic mastocytosis publication-title: J Intern Med – volume: 113 start-page: 180 year: 2004 ident: 10.1016/j.jaci.2008.11.018_bib35 article-title: Negative venom skin test results and mastocytosis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2003.10.013 – volume: 141 start-page: 1110 year: 1999 ident: 10.1016/j.jaci.2008.11.018_bib14 article-title: Mastocytosis associated with severe wasp sting anaphylaxis detected by elevated serum mast cell tryptase levels publication-title: Br J Dermatol doi: 10.1046/j.1365-2133.1999.03214.x – start-page: 291 year: 2001 ident: 10.1016/j.jaci.2008.11.018_bib2 article-title: Mastocytosis – volume: 170 start-page: 5667 year: 2003 ident: 10.1016/j.jaci.2008.11.018_bib16 article-title: Tryptase precursors are preferentially and spontaneously released, whereas mature tryptase is retained by HMC-1 cells, Mono-Mac-6 cells, and human skin-derived mast cells publication-title: J Immunol doi: 10.4049/jimmunol.170.11.5667 – volume: 25 start-page: 529 year: 2001 ident: 10.1016/j.jaci.2008.11.018_bib24 article-title: Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis publication-title: Leuk Res doi: 10.1016/S0145-2126(01)00041-8 – volume: 142 start-page: 158 year: 2007 ident: 10.1016/j.jaci.2008.11.018_bib5 article-title: Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: monoclonal mast cell activation syndrome publication-title: Int Arch Allergy Immunol doi: 10.1159/000096442 – volume: 114 start-page: 3 year: 2004 ident: 10.1016/j.jaci.2008.11.018_bib34 article-title: Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2004.02.045 – volume: 72 start-page: 685 year: 1983 ident: 10.1016/j.jaci.2008.11.018_bib11 article-title: Anaphylaxis after Hymenoptera stings in three patients with urticaria pigmentosa publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(83)90630-9 – volume: 100 start-page: 11 year: 1997 ident: 10.1016/j.jaci.2008.11.018_bib18 article-title: Hymenoptera sting anaphylaxis and urticaria pigmentosa: clinical findings and results of venom immunotherapy in ten patients publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(97)70188-X – volume: 128 start-page: 136 year: 2002 ident: 10.1016/j.jaci.2008.11.018_bib30 article-title: Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of disease publication-title: Int Arch Allergy Immunol doi: 10.1159/000059404 – volume: 316 start-page: 1622 year: 1987 ident: 10.1016/j.jaci.2008.11.018_bib17 article-title: Tryptase levels as an indicator of mast cell activation in systemic anaphylaxis and mastocytosis publication-title: N Engl J Med doi: 10.1056/NEJM198706253162603 – volume: 33 start-page: 1216 year: 2003 ident: 10.1016/j.jaci.2008.11.018_bib15 article-title: Elevated basal serum tryptase and Hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy publication-title: Clin Exp Allergy doi: 10.1046/j.1365-2222.2003.01755.x – volume: 87 start-page: 3117 year: 1996 ident: 10.1016/j.jaci.2008.11.018_bib1 article-title: A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells publication-title: Blood doi: 10.1182/blood.V87.8.3117.bloodjournal8783117 – volume: 48 start-page: 48 year: 1993 ident: 10.1016/j.jaci.2008.11.018_bib23 article-title: The European Academy of Allergology and Clinical Immunology. Position paper: allergen standardisation and skin tests publication-title: Allergy – volume: 12 start-page: 312 year: 1996 ident: 10.1016/j.jaci.2008.11.018_bib4 article-title: Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm publication-title: Nat Genet doi: 10.1038/ng0396-312 – volume: 3 start-page: 331 year: 1966 ident: 10.1016/j.jaci.2008.11.018_bib21 article-title: Mueller HL Diagnosis and treatment of insect sensitivity publication-title: J Asthma Res doi: 10.3109/02770906609106941 – volume: 99 start-page: 153 year: 1997 ident: 10.1016/j.jaci.2008.11.018_bib12 article-title: Fatal anaphylaxis after a yellow jacket sting, despite venom immunotherapy, in two patients with mastocytosis publication-title: J Allergy Clin Immunol doi: 10.1016/S0091-6749(97)70314-2 – volume: 17 start-page: 65 year: 2007 ident: 10.1016/j.jaci.2008.11.018_bib32 article-title: Basal serum tryptase level correlates with severity of Hymenoptera sting and age publication-title: J Investig Allergol Clin Immunol – volume: 127 start-page: 147 year: 2002 ident: 10.1016/j.jaci.2008.11.018_bib8 article-title: Mastocytosis: mediator-related signs and symptoms publication-title: Int Arch Allergy Immunol doi: 10.1159/000048188 – volume: 357 start-page: 361 year: 2001 ident: 10.1016/j.jaci.2008.11.018_bib13 article-title: Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reaction to Hymenoptera sting publication-title: Lancet doi: 10.1016/S0140-6736(00)03647-3 – volume: 37 start-page: 1547 year: 2007 ident: 10.1016/j.jaci.2008.11.018_bib27 article-title: Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA) publication-title: Clin Exp Allergy doi: 10.1111/j.1365-2222.2007.02804.x – volume: 113 start-page: 832 year: 2004 ident: 10.1016/j.jaci.2008.11.018_bib22 article-title: Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2003.12.591 – volume: 233 start-page: 255 year: 1993 ident: 10.1016/j.jaci.2008.11.018_bib10 article-title: Anaphylactoid shock following Hymenoptera sting as a presenting symptom of systemic mastocytosis publication-title: J Intern Med doi: 10.1111/j.1365-2796.1993.tb00984.x – volume: 121 start-page: 256 year: 2008 ident: 10.1016/j.jaci.2008.11.018_bib33 article-title: Allergen specific immunotherapy is safe and effective in patients with systemic mastocytosis and Hymenoptera allergy publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2007.10.014 – volume: 74 start-page: 121 year: 2007 ident: 10.1016/j.jaci.2008.11.018_bib7 article-title: Mastocytosis: state of the art publication-title: Pathobiology doi: 10.1159/000101711 – volume: 8 start-page: 412 year: 2006 ident: 10.1016/j.jaci.2008.11.018_bib26 article-title: Molecular diagnosis of mast cell disorders: a paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology publication-title: J Mol Diagn doi: 10.2353/jmoldx.2006.060022 – volume: 110 start-page: 2331 year: 2007 ident: 10.1016/j.jaci.2008.11.018_bib6 article-title: Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with “idiopathic” anaphylaxis publication-title: Blood doi: 10.1182/blood-2006-06-028100 – volume: 60 start-page: 1339 year: 2005 ident: 10.1016/j.jaci.2008.11.018_bib20 article-title: EAACI Interest Group on Insect Venom Hypersensitivity. Diagnosis of Hymenoptera venom allergy publication-title: Allergy doi: 10.1111/j.1398-9995.2005.00963.x – volume: 92 start-page: 10560 year: 1995 ident: 10.1016/j.jaci.2008.11.018_bib3 article-title: Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.92.23.10560 – volume: 37 start-page: 435 year: 2007 ident: 10.1016/j.jaci.2008.11.018_bib9 article-title: Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria publication-title: Eur J Clin Invest doi: 10.1111/j.1365-2362.2007.01807.x – volume: 63 start-page: 226 year: 2008 ident: 10.1016/j.jaci.2008.11.018_bib28 article-title: Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients publication-title: Allergy doi: 10.1111/j.1398-9995.2007.01569.x – volume: 6 start-page: 284 year: 2006 ident: 10.1016/j.jaci.2008.11.018_bib19 article-title: Mastocytosis and Hymenoptera venom allergy publication-title: Curr Opin Allergy Clin Immunol doi: 10.1097/01.all.0000235903.10548.63 – volume: 4 start-page: 291 year: 2004 ident: 10.1016/j.jaci.2008.11.018_bib31 article-title: Mastocytosis and Hymenoptera allergy publication-title: Curr Opin Allergy Clin Immunol doi: 10.1097/01.all.0000136756.20701.f8 – volume: 25 start-page: 571 year: 2001 ident: 10.1016/j.jaci.2008.11.018_bib25 article-title: Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy publication-title: Leuk Res doi: 10.1016/S0145-2126(01)00028-5 – volume: 357 start-page: 1527 year: 2001 ident: 10.1016/j.jaci.2008.11.018_bib29 article-title: Hymenoptera stings and serum tryptase publication-title: Lancet doi: 10.1016/S0140-6736(00)04677-8 – reference: 19281912 - J Allergy Clin Immunol. 2009 Mar;123(3):687-8 |
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| Snippet | Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic... Background Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations... |
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| Title | Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels |
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