Atheroprotective Immunity and Interleukin-10 Linked to Reduced Characteristics of Plaque Stability

[Display omitted] •Ongoing development of immunotherapies for cardiovascular disease aims to boost atheroprotective responses.•Studying the long-term implications of atheroprotective immunity in mice revealed 2 distinct pathways.•The IL-10 pathway was associated with characteristics of reduced plaqu...

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Bibliographic Details
Published in:	JACC-BASIC TO TRANSLATIONAL SCIENCE Vol. 10; no. 8; p. 101322
Main Authors:	Yu, Yinda, Lin, Shiying, Pan, Yueyun, He, Ning, Wu, Yanzhao, Ahmed, Osman, Hedin, Ulf, Karlsson, Mikael C.I., Li, Nailin, Gisterå, Anton
Format:	Journal Article Publication
Language:	English
Published:	United States Elsevier Inc 01.08.2025 Elsevier
Subjects:	adaptive immunity apolipoprotein B-100 atherosclerosis Cardiovascular cardiovascular disease LDL lipoproteins Original Research - Preclinical T-lymphocyte atherosclerosis cardiovascular disease TCR IL Treg adaptive immunity apoB BT Tr1 apolipoprotein B-100 Th LDL HuBL T-lymphocyte lipoproteins human APOB100-transgenic Ldlr −/ − mice regulatory T cell low-density lipoprotein T-cell receptor type 1 regulatory T cell T-helper interleukin apolipoprotein B apolipoprotein B–reactive T cell
ISSN:	2452-302X, 2452-302X
Online Access:	Get full text
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