Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

Diabetic patients respond poorly to revascularization for peripheral arterial disease (PAD) but the underlying mechanisms are not well understood. We aimed to determine whether diabetes worsens ischemia-reperfusion (IR)-induced muscle dysfunction and the involvement of endogenous protective kinases...

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Bibliographic Details
Published in:	Frontiers in physiology Vol. 9; p. 579
Main Authors:	Pottecher, Julien, Adamopoulos, Chris, Lejay, Anne, Bouitbir, Jamal, Charles, Anne-Laure, Meyer, Alain, Singer, Mervyn, Wolff, Valerie, Diemunsch, Pierre, Laverny, Gilles, Metzger, Daniel, Geny, Bernard
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers 22.05.2018 Frontiers Media S.A
Subjects:	Cellular Biology diabetes ischemia-reperfusion Life Sciences mitochondria muscles peripheral arterial disease Physiology protective kinases Subcellular Processes peripheral arterial disease muscles ischemia-reperfusion diabetes mitochondria protective kinases
ISSN:	1664-042X, 1664-042X
Online Access:	Get full text
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