Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development

The three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating changes in transcription during human development. To better understand the mechanisms underlying context-specific 3D chromatin structure and tran...

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Veröffentlicht in:	Molecular cell Jg. 67; H. 6; S. 1037
Hauptverfasser:	Phanstiel, Douglas H, Van Bortle, Kevin, Spacek, Damek, Hess, Gaelen T, Shamim, Muhammad Saad, Machol, Ido, Love, Michael I, Aiden, Erez Lieberman, Bassik, Michael C, Snyder, Michael P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.09.2017
Schlagworte:	Binding Sites Cell Differentiation Cell Line, Tumor Chromatin - chemistry Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly DNA - chemistry DNA - genetics DNA - metabolism Enhancer Elements, Genetic Gene Expression Regulation High-Throughput Nucleotide Sequencing Humans Macrophages - metabolism Nucleic Acid Conformation Phenotype Protein Binding Time Factors Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transcription, Genetic CTCF cellular differentiation DNA looping Hi-C AP-1
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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