Specific alterations in gut microbiota in patients with chronic kidney disease: an updated systematic review

Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely expl...

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Veröffentlicht in:Renal failure Jg. 43; H. 1; S. 102 - 112
Hauptverfasser: Zhao, Jin, Ning, Xiaoxuan, Liu, Baojian, Dong, Ruijuan, Bai, Ming, Sun, Shiren
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Taylor & Francis 01.01.2021
Taylor & Francis Ltd
Taylor & Francis Group
Schlagworte:
Abundance
Chronic kidney disease
Dysbacteriosis
End-stage renal disease
Faecalibacterium
Fatty acids
Gut microbiota
Intestinal microflora
Kidney diseases
Metabolic disorders
Microbiota
Mucosa
Mucosal immunity
Permeability
Prevotella
Proteobacteria
Review
State-of-the-Art Review
Streptococcus
systematic review
Trimethylamine
Trimethylamine-N-oxide
Chronic kidney disease
end-stage renal disease
systematic review
gut microbiota
ISSN:0886-022X, 1525-6049, 1525-6049
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Zusammenfassung:Emerging evidence demonstrates that gut dysbiosis is implicated in the pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving mucosal and/or systematic immunity or metabolic disorders. However, the profile of gut microbiota in patients with CKD has not been completely explored. Databases from their date of inception to 31 March 2020 were systematically searched for case-control or cross-sectional studies comparing the gut microbial profiles in adult patients with CKD or end-stage renal disease (ESRD) with those in healthy controls. Quantitative analysis of alterations in gut microbial profiles was conducted. Twenty-five studies with a total of 1436 CKD patients and 918 healthy controls were included. The present study supports the increased abundance of, phylum Proteobacteria and Fusobacteria, genus Escherichia_Shigella, Desulfovibrio, and Streptococcus, while lower abundance of genus Roseburia, Faecalibacterium, Pyramidobacter, Prevotellaceae_UCG-001, and Prevotella_9 in patients with CKD; and increased abundance of phylum Proteobacteria, and genus Streptococcus and Fusobacterium, while lower abundance of Prevotella, Coprococcus, Megamonas, and Faecalibacterium in patients with ESRD. Moreover, higher concentrations of trimethylamine-N-oxide and p-cresyl sulfate and lower concentrations of short-chain fatty acids were observed. Gut permeability in patients with CKD was not determined due to the heterogeneity of selected parameters. Specific alterations of gut microbial parameters in patients with CKD were identified. However, a full picture of the gut microbiota could not be drawn from the data due to the differences in methodology, and qualitative and incomplete reporting of different studies.
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Both authors contributed equally to this work.
Supplemental data for this article can be accessed here.
Ming Bai and Shiren Sun contributed equally to this work, and they are Co-Corresponding authors.
ISSN:0886-022X
1525-6049
1525-6049
DOI:10.1080/0886022X.2020.1864404