Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known as "diabetes." Increased knowledge of this condition has emerged from populations around the world, illuminating the differences i...

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Vydáno v:Diabetes care Ročník 43; číslo 7; s. 1617
Hlavní autoři: Chung, Wendy K, Erion, Karel, Florez, Jose C, Hattersley, Andrew T, Hivert, Marie-France, Lee, Christine G, McCarthy, Mark I, Nolan, John J, Norris, Jill M, Pearson, Ewan R, Philipson, Louis, McElvaine, Allison T, Cefalu, William T, Rich, Stephen S, Franks, Paul W
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.07.2020
Témata:
ISSN:1935-5548, 1935-5548
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Abstract The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known as "diabetes." Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence, and how best practice in treatment varies between populations. In parallel, focus has been placed on the development of tools for the application of precision medicine to numerous conditions. This Consensus Report presents the American Diabetes Association (ADA) Precision Medicine in Diabetes Initiative in partnership with the European Association for the Study of Diabetes (EASD), including its mission, the current state of the field, and prospects for the future. Expert opinions are presented on areas of precision diagnostics and precision therapeutics (including prevention and treatment), and key barriers to and opportunities for implementation of precision diabetes medicine, with better care and outcomes around the globe, are highlighted. Cases where precision diagnosis is already feasible and effective (i.e., monogenic forms of diabetes) are presented, while the major hurdles to the global implementation of precision diagnosis of complex forms of diabetes are discussed. The situation is similar for precision therapeutics, in which the appropriate therapy will often change over time owing to the manner in which diabetes evolves within individual patients. This Consensus Report describes a foundation for precision diabetes medicine, while highlighting what remains to be done to realize its potential. This, combined with a subsequent, detailed evidence-based review (due 2022), will provide a roadmap for precision medicine in diabetes that helps improve the quality of life for all those with diabetes.
AbstractList The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known as "diabetes." Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence, and how best practice in treatment varies between populations. In parallel, focus has been placed on the development of tools for the application of precision medicine to numerous conditions. This Consensus Report presents the American Diabetes Association (ADA) Precision Medicine in Diabetes Initiative in partnership with the European Association for the Study of Diabetes (EASD), including its mission, the current state of the field, and prospects for the future. Expert opinions are presented on areas of precision diagnostics and precision therapeutics (including prevention and treatment), and key barriers to and opportunities for implementation of precision diabetes medicine, with better care and outcomes around the globe, are highlighted. Cases where precision diagnosis is already feasible and effective (i.e., monogenic forms of diabetes) are presented, while the major hurdles to the global implementation of precision diagnosis of complex forms of diabetes are discussed. The situation is similar for precision therapeutics, in which the appropriate therapy will often change over time owing to the manner in which diabetes evolves within individual patients. This Consensus Report describes a foundation for precision diabetes medicine, while highlighting what remains to be done to realize its potential. This, combined with a subsequent, detailed evidence-based review (due 2022), will provide a roadmap for precision medicine in diabetes that helps improve the quality of life for all those with diabetes.
The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known as "diabetes." Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence, and how best practice in treatment varies between populations. In parallel, focus has been placed on the development of tools for the application of precision medicine to numerous conditions. This Consensus Report presents the American Diabetes Association (ADA) Precision Medicine in Diabetes Initiative in partnership with the European Association for the Study of Diabetes (EASD), including its mission, the current state of the field, and prospects for the future. Expert opinions are presented on areas of precision diagnostics and precision therapeutics (including prevention and treatment), and key barriers to and opportunities for implementation of precision diabetes medicine, with better care and outcomes around the globe, are highlighted. Cases where precision diagnosis is already feasible and effective (i.e., monogenic forms of diabetes) are presented, while the major hurdles to the global implementation of precision diagnosis of complex forms of diabetes are discussed. The situation is similar for precision therapeutics, in which the appropriate therapy will often change over time owing to the manner in which diabetes evolves within individual patients. This Consensus Report describes a foundation for precision diabetes medicine, while highlighting what remains to be done to realize its potential. This, combined with a subsequent, detailed evidence-based review (due 2022), will provide a roadmap for precision medicine in diabetes that helps improve the quality of life for all those with diabetes.The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known as "diabetes." Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence, and how best practice in treatment varies between populations. In parallel, focus has been placed on the development of tools for the application of precision medicine to numerous conditions. This Consensus Report presents the American Diabetes Association (ADA) Precision Medicine in Diabetes Initiative in partnership with the European Association for the Study of Diabetes (EASD), including its mission, the current state of the field, and prospects for the future. Expert opinions are presented on areas of precision diagnostics and precision therapeutics (including prevention and treatment), and key barriers to and opportunities for implementation of precision diabetes medicine, with better care and outcomes around the globe, are highlighted. Cases where precision diagnosis is already feasible and effective (i.e., monogenic forms of diabetes) are presented, while the major hurdles to the global implementation of precision diagnosis of complex forms of diabetes are discussed. The situation is similar for precision therapeutics, in which the appropriate therapy will often change over time owing to the manner in which diabetes evolves within individual patients. This Consensus Report describes a foundation for precision diabetes medicine, while highlighting what remains to be done to realize its potential. This, combined with a subsequent, detailed evidence-based review (due 2022), will provide a roadmap for precision medicine in diabetes that helps improve the quality of life for all those with diabetes.
Author Rich, Stephen S
Norris, Jill M
Philipson, Louis
Chung, Wendy K
Hivert, Marie-France
Hattersley, Andrew T
McElvaine, Allison T
Lee, Christine G
Pearson, Ewan R
McCarthy, Mark I
Erion, Karel
Cefalu, William T
Florez, Jose C
Nolan, John J
Franks, Paul W
Author_xml – sequence: 1
  givenname: Wendy K
  surname: Chung
  fullname: Chung, Wendy K
  organization: Department of Medicine, Columbia University Irving Medical Center, New York, NY
– sequence: 2
  givenname: Karel
  surname: Erion
  fullname: Erion, Karel
  organization: American Diabetes Association, Arlington, VA
– sequence: 3
  givenname: Jose C
  orcidid: 0000-0002-1730-9325
  surname: Florez
  fullname: Florez, Jose C
  organization: Department of Medicine, Harvard Medical School, Boston, MA
– sequence: 4
  givenname: Andrew T
  orcidid: 0000-0001-5620-473X
  surname: Hattersley
  fullname: Hattersley, Andrew T
  organization: Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, U.K
– sequence: 5
  givenname: Marie-France
  orcidid: 0000-0001-7752-2585
  surname: Hivert
  fullname: Hivert, Marie-France
  organization: Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA
– sequence: 6
  givenname: Christine G
  surname: Lee
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  organization: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
– sequence: 7
  givenname: Mark I
  surname: McCarthy
  fullname: McCarthy, Mark I
  organization: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K
– sequence: 8
  givenname: John J
  orcidid: 0000-0003-3648-1590
  surname: Nolan
  fullname: Nolan, John J
  organization: School of Medicine, Trinity College, Dublin, Ireland
– sequence: 9
  givenname: Jill M
  orcidid: 0000-0001-8674-2598
  surname: Norris
  fullname: Norris, Jill M
  organization: Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO
– sequence: 10
  givenname: Ewan R
  orcidid: 0000-0001-9237-8585
  surname: Pearson
  fullname: Pearson, Ewan R
  organization: Division of Population Health and Genomics, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, Scotland, U.K
– sequence: 11
  givenname: Louis
  surname: Philipson
  fullname: Philipson, Louis
  organization: Department of Pediatrics, University of Chicago, Chicago, IL
– sequence: 12
  givenname: Allison T
  orcidid: 0000-0002-0654-4047
  surname: McElvaine
  fullname: McElvaine, Allison T
  organization: Duke University School of Medicine, Durham, NC
– sequence: 13
  givenname: William T
  surname: Cefalu
  fullname: Cefalu, William T
  organization: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
– sequence: 14
  givenname: Stephen S
  orcidid: 0000-0003-3872-7793
  surname: Rich
  fullname: Rich, Stephen S
  organization: Department of Public Health Sciences, University of Virginia, Charlottesville, VA
– sequence: 15
  givenname: Paul W
  orcidid: 0000-0002-0520-7604
  surname: Franks
  fullname: Franks, Paul W
  email: paul.franks@med.lu.se
  organization: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32561617$$D View this record in MEDLINE/PubMed
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PublicationTitle Diabetes care
PublicationTitleAlternate Diabetes Care
PublicationYear 2020
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Snippet The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known...
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SubjectTerms Biomedical Research - economics
Biomedical Research - organization & administration
Biomedical Research - standards
Biomedical Research - trends
Consensus
Diabetes Mellitus - therapy
Endocrinology - economics
Endocrinology - organization & administration
Endocrinology - standards
Europe
Evidence-Based Medicine
Financial Management
Health Plan Implementation - standards
Humans
Practice Guidelines as Topic - standards
Practice Patterns, Physicians' - standards
Precision Medicine - economics
Precision Medicine - methods
Precision Medicine - standards
Quality of Life
Societies, Medical - economics
Societies, Medical - organization & administration
Societies, Medical - standards
United States
Title Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
URI https://www.ncbi.nlm.nih.gov/pubmed/32561617
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