LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis

The renal interstitial fibrosis contributes to the progression and deterioration of diabetic nephropathy (DN). Long noncoding RNA taurine-up-regulated gene 1 (TUG1) in kidneys may be down-regulated by hyperglycemia. We aim to explore its role in tubular fibrosis caused by high glucose and the possib...

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Bibliographic Details
Published in:	Renal failure Vol. 45; no. 1; p. 2173950
Main Authors:	Wang, Taoxia, Cui, Shubei, Liu, Xiaoli, Han, Li, Duan, Xiaoting, Feng, Shuning, Zhang, Sen, Li, Guiying
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 01.12.2023 Taylor & Francis Ltd Taylor & Francis Group
Subjects:	Animals Clinical Study Diabetes Diabetes Mellitus Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic nephropathy Dual Specificity Phosphatase 6 - metabolism DUSP6 Fibrosis Gene silencing Glucose Hyperglycemia Inflammation interstitial fibrosis Kidneys lncTUG1 Mice MicroRNAs - genetics MicroRNAs - metabolism miR-145-5p Nephropathy Phosphatase RNA, Long Noncoding Streptozocin Taurine Diabetic nephropathy interstitial fibrosis lncTUG1 inflammation DUSP6 miR-145-5p
ISSN:	0886-022X, 1525-6049, 1525-6049
Online Access:	Get full text
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