Atopic Dermatitis Treated Safely with Dupilumab during Pregnancy: A Case Report and Review of the Literature

Abstract Dupilumab is currently the only biologic treatment approved for moderate-to-severe atopic dermatitis. Though limited, available clinical data describing dupilumab use in pregnancy have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal ou...

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Bibliographic Details
Published in:Case reports in dermatology Vol. 13; no. 2; pp. 248 - 256
Main Authors: Lobo, Yolanka, Lee, Ruby C., Spelman, Lynda
Format: Journal Article
Language:English
Published: Basel, Switzerland S. Karger AG 01.05.2021
Karger Publishers
Subjects:
Antibodies
atopic dermatitis
Birth defects
Breastfeeding & lactation
Case and Review
Case reports
Dermatitis
Drug dosages
dupilumab
Eczema
Fetuses
Gastroenterology
Immunoglobulins
Inflammatory bowel disease
Light therapy
Miscarriage
Monoclonal antibodies
Patients
Pregnancy
Quality of life
Steroids
Womens health
Pregnancy
Atopic dermatitis
Dupilumab
ISSN:1662-6567, 1662-6567
Online Access:Get full text
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Summary:Abstract Dupilumab is currently the only biologic treatment approved for moderate-to-severe atopic dermatitis. Though limited, available clinical data describing dupilumab use in pregnancy have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. Systemic treatment in pregnant women with atopic dermatitis is currently restricted to corticosteroids, cyclosporine A, and azathioprine. Atopic dermatitis often has a deleterious course in pregnancy which can cause substantial distress and significantly impact on global health and quality of life. We report a case of severe atopic dermatitis treated safely with dupilumab during pregnancy with no adverse maternal or fetal outcomes observed. Our case highlights that dupilumab use in pregnancy has its place but should always be preceded by careful assessment of the risks and benefits. Clinicians are encouraged to enroll their patients in relevant pregnancy registry studies to monitor outcomes in women exposed to dupilumab during pregnancy and lactation.
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ISSN:1662-6567
1662-6567
DOI:10.1159/000515246