Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

Cell-cell communication via ligand-receptor signaling is a fundamental feature of complex organs. Despite this, the global landscape of intercellular signaling in mammalian liver has not been elucidated. Here we perform single-cell RNA sequencing on non-parenchymal cells isolated from healthy and NA...

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Bibliographic Details
Published in:	Molecular cell Vol. 75; no. 3; p. 644
Main Authors:	Xiong, Xuelian, Kuang, Henry, Ansari, Sahar, Liu, Tongyu, Gong, Jianke, Wang, Shuai, Zhao, Xu-Yun, Ji, Yewei, Li, Chuan, Guo, Liang, Zhou, Linkang, Chen, Zhimin, Leon-Mimila, Paola, Chung, Meng Ting, Kurabayashi, Katsuo, Opp, Judy, Campos-Pérez, Francisco, Villamil-Ramírez, Hugo, Canizales-Quinteros, Samuel, Lyons, Robert, Lumeng, Carey N, Zhou, Beiyan, Qi, Ling, Huertas-Vazquez, Adriana, Lusis, Aldons J, Xu, X Z Shawn, Li, Siming, Yu, Yonghao, Li, Jun Z, Lin, Jiandie D
Format:	Journal Article
Language:	English
Published:	United States 08.08.2019
Subjects:	Animals Cell Communication - genetics Cellular Reprogramming - genetics Disease Models, Animal Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Humans Ligands Liver - metabolism Liver - pathology Macrophages - metabolism Macrophages - pathology Mice Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Sequence Analysis, RNA Signal Transduction - genetics Single-Cell Analysis NPC NAFLD scRNA-seq liver Kupffer single-cell HSC Trem2 macrophage NASH secretome stellakine
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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