A computational algorithm to predict shRNA potency

The strength of conclusions drawn from RNAi-based studies is heavily influenced by the quality of tools used to elicit knockdown. Prior studies have developed algorithms to design siRNAs. However, to date, no established method has emerged to identify effective shRNAs, which have lower intracellular...

Celý popis

Podrobná bibliografia

Vydané v:	Molecular cell Ročník 56; číslo 6; s. 796
Hlavní autori:	Knott, Simon R V, Maceli, Ashley, Erard, Nicolas, Chang, Kenneth, Marran, Krista, Zhou, Xin, Gordon, Assaf, Demerdash, Osama El, Wagenblast, Elvin, Kim, Sun, Fellmann, Christof, Hannon, Gregory J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 18.12.2014
Predmet:	Algorithms Base Sequence Cell Line, Tumor Computer Simulation Consensus Sequence Gene Knockdown Techniques Humans MicroRNAs - genetics Models, Genetic Molecular Sequence Data RNA, Small Interfering - genetics Software
ISSN:	1097-4164, 1097-4164
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!