Mechanisms Controlling PD-L1 Expression in Cancer

The engagement of programmed cell death protein 1 (PD-1; encoded by the PDCD1 gene) receptor expressed on activated T cells and its ligand, programmed death-ligand 1 (PD-L1; encoded by the CD274 gene), is a major co-inhibitory checkpoint signaling that controls T cell activities. Various types of ca...

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Bibliographic Details
Published in:	Molecular cell Vol. 76; no. 3; p. 359
Main Authors:	Cha, Jong-Ho, Chan, Li-Chuan, Li, Chia-Wei, Hsu, Jennifer L, Hung, Mien-Chie
Format:	Journal Article
Language:	English
Published:	United States 07.11.2019
Subjects:	Animals Antineoplastic Agents, Immunological - therapeutic use B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - genetics B7-H1 Antigen - immunology B7-H1 Antigen - metabolism Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology Biomarkers, Tumor - metabolism Gene Expression Regulation, Neoplastic Humans Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Protein Processing, Post-Translational RNA Processing, Post-Transcriptional Signal Transduction Transcription, Genetic Tumor Escape
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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