Industrial Trans Fatty Acids Stimulate SREBP2‐Mediated Cholesterogenesis and Promote Non‐Alcoholic Fatty Liver Disease

Scope The mechanisms underlying the deleterious effects of trans fatty acids on plasma cholesterol and non‐alcoholic fatty liver disease (NAFLD) are unclear. Here, the aim is to investigate the molecular mechanisms of action of industrial trans fatty acids. Methods and results Hepa1‐6 hepatoma cells...

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Bibliographic Details
Published in:	Molecular nutrition & food research Vol. 63; no. 19; pp. e1900385 - n/a
Main Authors:	Oteng, Antwi‐Boasiako, Loregger, Anke, Weeghel, Michel, Zelcer, Noam, Kersten, Sander
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01.10.2019 John Wiley and Sons Inc
Subjects:	3T3-L1 Cells Alanine Alanine transaminase Animals Biosynthesis Body fat Carcinoma, Hepatocellular Cell Line, Tumor CHO Cells cholesterogenesis Cholesterol Cholesterol - biosynthesis Cholesterol - genetics cholesterol metabolism Cricetulus Diet Dietary Fats - pharmacology elaidate enzyme activity Fatty acids Fatty liver Fibrosis Gene expression Gene Expression - drug effects gonads Hepatoma Intracellular Intracellular Signaling Peptides and Proteins - physiology Liver Liver - drug effects Liver - metabolism Liver - pathology Liver diseases Liver X receptors Male mechanism of action Membrane Proteins - physiology Mice Mice, Inbred C57BL Molecular modelling Non-alcoholic Fatty Liver Disease - chemically induced Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology non‐alcoholic fatty liver disease oleic acid Oleic Acids - pharmacology palmitates Palmitic acid Proteins saturated fatty acids Steatosis Sterol Regulatory Element Binding Protein 2 - physiology sterol regulatory element binding proteins Sterol regulatory element-binding protein Trans fats Trans fatty acids Trans Fatty Acids - pharmacology transcriptomics Ubiquitin elaidate non-alcoholic fatty liver disease sterol regulatory element binding proteins cholesterol metabolism cholesterogenesis
ISSN:	1613-4125, 1613-4133, 1613-4133
Online Access:	Get full text
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