Hypertension and related diseases in the era of COVID-19: a report from the Japanese Society of Hypertension Task Force on COVID-19

Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected more than seven million people worldwide, contributing to 0.4 million deaths as of June 2020. The fact that the virus uses angiotensin-converting enzyme (ACE)-2 as the cell entry...

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Vydané v:	Hypertension research Ročník 43; číslo 10; s. 1028 - 1046
Hlavní autori:	Shibata, Shigeru, Arima, Hisatomi, Asayama, Kei, Hoshide, Satoshi, Ichihara, Atsuhiro, Ishimitsu, Toshihiko, Kario, Kazuomi, Kishi, Takuya, Mogi, Masaki, Nishiyama, Akira, Ohishi, Mitsuru, Ohkubo, Takayoshi, Tamura, Kouichi, Tanaka, Masami, Yamamoto, Eiichiro, Yamamoto, Koichi, Itoh, Hiroshi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Nature Publishing Group 01.10.2020
Predmet:	Angiotensin-Converting Enzyme 2 Antihypertensive Agents - therapeutic use Betacoronavirus - metabolism Cerebrovascular Disorders - virology Coronavirus Infections - complications Coronavirus Infections - mortality Coronaviruses COVID-19 Diuretics Host-Pathogen Interactions Humans Hypertension Hypertension - complications Hypertension - drug therapy Hypertension - epidemiology Pandemics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - complications Pneumonia, Viral - mortality SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 cardiovascular disease severe acute respiratory syndrome coronavirus 2 angiotensin converting enzyme 2 hypertension
ISSN:	0916-9636, 1348-4214, 1348-4214
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Shrnutí:	Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected more than seven million people worldwide, contributing to 0.4 million deaths as of June 2020. The fact that the virus uses angiotensin-converting enzyme (ACE)-2 as the cell entry receptor and that hypertension as well as cardiovascular disorders frequently coexist with COVID-19 have generated considerable discussion on the management of patients with hypertension. In addition, the COVID-19 pandemic necessitates the development of and adaptation to a "New Normal" lifestyle, which will have a profound impact not only on communicable diseases but also on noncommunicable diseases, including hypertension. Summarizing what is known and what requires further investigation in this field may help to address the challenges we face. In the present review, we critically evaluate the existing evidence for the epidemiological association between COVID-19 and hypertension. We also summarize the current knowledge regarding the pathophysiology of SARS-CoV-2 infection with an emphasis on ACE2, the cardiovascular system, and the kidney. Finally, we review evidence on the use of antihypertensive medication, namely, ACE inhibitors and angiotensin receptor blockers, in patients with COVID-19.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0916-9636 1348-4214 1348-4214
DOI:	10.1038/s41440-020-0515-0