Association of pulmonary function with the risk of stroke based on the NHANES database

Background Stroke is a significant cause of morbidity and mortality worldwide, often associated with various risk factors including age, hypertension, and diabetes. This study aimed to investigate the relationship between pulmonary function and the presence of stroke, accounting for demographic and...

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Published in:BMC public health Vol. 25; no. 1; pp. 2239 - 7
Main Authors: Shi, Licheng, Yang, Yin, Su, Yingying, Liu, Jiannan, Zhu, Xuanfeng
Format: Journal Article
Language:English
Published: London BioMed Central 02.07.2025
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Adult
Age
Aged
Biostatistics
Blood pressure
Body mass index
Body size
Cardiovascular disease
Cholesterol
Chronic obstructive pulmonary disease
Complications and side effects
Confidence intervals
Databases, Factual
Demographic variables
Demographics
Demography
Development and progression
Diabetes
Diabetes mellitus
Disease prevention
Environmental Health
Epidemiology
Exercise
Female
FEV1
Forced Expiratory Volume
FVC
Gender
Health aspects
Health risks
Health surveys
Heart rate
Humans
Hypertension
Lung diseases
Male
Medicine
Medicine & Public Health
Middle Aged
Morbidity
Mortality
Nutrition Surveys
Obesity
PEF
Pepper spray
Population
Prevention
Public Health
Pulmonary function
Pulmonary functions
Pulmonary ventilation
Regression analysis
Respiratory function
Respiratory Function Tests
Respiratory insufficiency
Risk assessment
Risk Factors
Risk management
Risk reduction
Spirometry
Statistical analysis
Stroke
Stroke (Disease)
Stroke - epidemiology
Stroke patients
Surveys
United States - epidemiology
Vaccine
Vital Capacity
United States
China
PEF
Stroke
FVC
FEV1
Pulmonary function
ISSN:1471-2458, 1471-2458
Online Access:Get full text
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Summary:Background Stroke is a significant cause of morbidity and mortality worldwide, often associated with various risk factors including age, hypertension, and diabetes. This study aimed to investigate the relationship between pulmonary function and the presence of stroke, accounting for demographic and clinical factors. Methods A total of 6700 participants were enrolled from National Health and Nutrition Examination Survey. Logistic regression analysis was conducted to calculated the odds ratio (OR) and 95% confidence interval (CI) of pulmonary function variables, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and peak expiratory flow rate (PEF), and the risk of stroke. Results Participants with stroke were older, had higher body mass index (BMI), and exhibited a higher prevalence of diabetes and hypertension. Additionally, stroke patients had significantly lower levels of FEV1, FVC, and PEF. Higher quartiles of FEV1 (OR 0.21, 95%CI 0.05 to 0.67; P  = 0.014), FVC (OR 0.29, 95%CI 0.10 to 0.82; P  = 0.023), and PEF (OR 0.22, 95%CI 0.08 to 0.57; P  = 0.003) were independently associated with risk of stroke after adjustment for demographic and clinical variables. Conclusion Higher levels of FEV1, FVC, and PEF were consistently associated with a reduced risk of stroke. These results highlight the potential importance of monitoring pulmonary function as a marker for stroke risk assessment and warrant further investigation into the underlying mechanisms of this association.
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ISSN:1471-2458
1471-2458
DOI:10.1186/s12889-025-23521-6