Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial
Background Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee ex...
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| Vydané v: | Current controlled trials in cardiovascular medicine Ročník 26; číslo 1; s. 222 - 15 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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London
BioMed Central
23.06.2025
BioMed Central Ltd Springer Nature B.V BMC |
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| ISSN: | 1745-6215, 1745-6215 |
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| Abstract | Background
Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA.
Methods
A minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance.
Discussion
This RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA.
Trial registration
ClinicalTrials.gov NCT06173193. Retrospectively registered before completion of the recruitment on 31 October 2023,
https://www.clinicaltrials.gov/study/NCT06173193
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| AbstractList | Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA.
A minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance.
This RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA.
ClinicalTrials.gov NCT06173193. Retrospectively registered before completion of the recruitment on 31 October 2023, https://www.
gov/study/NCT06173193 . BackgroundKnee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA.MethodsA minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance.DiscussionThis RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA.Trial registrationClinicalTrials.gov NCT06173193. Retrospectively registered before completion of the recruitment on 31 October 2023, https://www.clinicaltrials.gov/study/NCT06173193. Background Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA. Methods A minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance. Discussion This RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA. Trial registration ClinicalTrials.gov NCT06173193. Retrospectively registered before completion of the recruitment on 31 October 2023, Keywords: Osteoarthritis, Knee, Subchondral bone, Cartilage, Exercise therapy Abstract Background Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA. Methods A minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance. Discussion This RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA. Trial registration ClinicalTrials.gov NCT06173193. Retrospectively registered before completion of the recruitment on 31 October 2023, https://www.clinicaltrials.gov/study/NCT06173193 . Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA. A minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance. This RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA. Background Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA. Methods A minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance. Discussion This RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA. Trial registration ClinicalTrials.gov NCT06173193. Retrospectively registered before completion of the recruitment on 31 October 2023, https://www.clinicaltrials.gov/study/NCT06173193 . Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA.BACKGROUNDKnee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core treatment recommendations for KOA and it has been suggested that optimal exercise regimens should improve aerobic capacity and knee extensor strength. Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. This article describes a clinical trial investigating the effects of a multicomponent exercise regimen on the subchondral bone and articular cartilage of the knee joint in postmenopausal women with mild KOA.A minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance.METHODSA minimum of 90 postmenopausal women between the ages of 55 and 75 meeting the inclusion criteria will be recruited. After an initial assessment, the participants will be randomly assigned to two groups. The intervention group will participate in a progressive multicomponent exercise regimen, including step aerobics and resistance training alternating every 2 weeks, for 50 min three times a week for 8 months. The reference group will be conducting home exercise program representing standard rehabilitative management for KOA patients. The primary outcome measures of this trial are the 8-month changes in the biochemical composition of the knee articular cartilage measured by the T1r and T2 relaxation times from quantitative magnetic resonance imaging and subchondral bone sclerosis, density and structure as measured via cone beam computed tomography. Measurements will be performed at baseline, after the 8-month intervention period, and at 12 months of maintenance.This RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA.DISCUSSIONThis RCT investigates the effectiveness of a multicomponent exercise regimen on the subchondral bone and cartilage of the knee joint and the potential interaction between these tissues. The information gained will improve our understanding of the effects of exercise on subchondral bone and the biochemical properties of articular cartilage and improve the prescription of multicomponent exercise regimens in the management of mild KOA.ClinicalTrials.gov NCT06173193. Retrospectively registered before completion of the recruitment on 31 October 2023, https://www.TRIAL REGISTRATIONClinicalTrials.gov NCT06173193. Retrospectively registered before completion of the recruitment on 31 October 2023, https://www.gov/study/NCT06173193 .CLINICALTRIALSgov/study/NCT06173193 . |
| ArticleNumber | 222 |
| Audience | Academic |
| Author | Peuna, Arttu Rantalainen, Timo Heinonen, Ari Munukka, Matti Kautiainen, Hannu Multanen, Juhani Vesanto, Johanna Paloneva, Juha Parkkari, Jari Nevalainen, Mika Ihalainen, Johanna K. Casula, Victor Saarakkala, Simo Konola, Ville-Markus Nikander, Riku Nieminen, Miika T. Kalaja, Merja Vasankari, Tommi Sievänen, Harri Pekkala, Satu Waller, Benjamin |
| Author_xml | – sequence: 1 givenname: Ville-Markus orcidid: 0009-0008-5243-4114 surname: Konola fullname: Konola, Ville-Markus email: ville.m.konola@jyu.fi organization: Faculty of Sport and Health Sciences, University of Jyväskylä – sequence: 2 givenname: Jari orcidid: 0000-0001-5211-9845 surname: Parkkari fullname: Parkkari, Jari organization: Faculty of Medicine and Health Technology, University of Tampere – sequence: 3 givenname: Juhani orcidid: 0000-0003-0811-3504 surname: Multanen fullname: Multanen, Juhani organization: South-Eastern Finland University of Applied Sciences – sequence: 4 givenname: Riku orcidid: 0000-0002-2072-0510 surname: Nikander fullname: Nikander, Riku organization: Faculty of Sport and Health Sciences, University of Jyväskylä, Wellbeing Services County of Central Finland – sequence: 5 givenname: Timo orcidid: 0000-0001-6977-4782 surname: Rantalainen fullname: Rantalainen, Timo organization: Faculty of Sport and Health Sciences, University of Jyväskylä – sequence: 6 givenname: Johanna orcidid: 0009-0000-2624-8133 surname: Vesanto fullname: Vesanto, Johanna organization: Faculty of Sport and Health Sciences, University of Jyväskylä, Wellbeing Services County of Central Finland – sequence: 7 givenname: Satu orcidid: 0000-0003-3107-0813 surname: Pekkala fullname: Pekkala, Satu organization: Faculty of Sport and Health Sciences, University of Jyväskylä – sequence: 8 givenname: Merja surname: Kalaja fullname: Kalaja, Merja organization: Faculty of Sport and Health Sciences, University of Jyväskylä – sequence: 9 givenname: Johanna K. orcidid: 0000-0001-9428-4689 surname: Ihalainen fullname: Ihalainen, Johanna K. organization: Faculty of Sport and Health Sciences, University of Jyväskylä – sequence: 10 givenname: Benjamin orcidid: 0000-0002-0738-0670 surname: Waller fullname: Waller, Benjamin organization: Finnish Institute of High Performance Sport KIHU – sequence: 11 givenname: Matti orcidid: 0000-0003-3101-466X surname: Munukka fullname: Munukka, Matti organization: Faculty of Sport and Health Sciences, University of Jyväskylä – sequence: 12 givenname: Harri orcidid: 0000-0003-3172-248X surname: Sievänen fullname: Sievänen, Harri organization: UKK Institute for Health Promotion Research – sequence: 13 givenname: Mika orcidid: 0000-0002-9483-7690 surname: Nevalainen fullname: Nevalainen, Mika organization: Research Unit of Health Sciences and Technology, University of Oulu, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Department of Diagnostic Radiology, Oulu University Hospital – sequence: 14 givenname: Hannu surname: Kautiainen fullname: Kautiainen, Hannu organization: Primary Health Care Unit, Kuopio University Hospital, Folkhälsan Research Center – sequence: 15 givenname: Victor orcidid: 0000-0003-0447-2796 surname: Casula fullname: Casula, Victor organization: Research Unit of Health Sciences and Technology, University of Oulu – sequence: 16 givenname: Juha orcidid: 0000-0003-3340-9390 surname: Paloneva fullname: Paloneva, Juha organization: Department of Surgery, Hospital Nova, Wellbeing Services County of Central Finland, University of Eastern Finland – sequence: 17 givenname: Tommi orcidid: 0000-0001-7209-9351 surname: Vasankari fullname: Vasankari, Tommi organization: Faculty of Medicine and Health Technology, University of Tampere, UKK Institute for Health Promotion Research – sequence: 18 givenname: Arttu orcidid: 0000-0002-2623-7458 surname: Peuna fullname: Peuna, Arttu organization: Department of Diagnostic Services, Hospital Nova, Wellbeing Services County of Central Finland – sequence: 19 givenname: Simo orcidid: 0000-0003-2850-5484 surname: Saarakkala fullname: Saarakkala, Simo organization: Research Unit of Health Sciences and Technology, University of Oulu, Department of Diagnostic Radiology, Oulu University Hospital – sequence: 20 givenname: Miika T. orcidid: 0000-0002-2300-2848 surname: Nieminen fullname: Nieminen, Miika T. organization: Research Unit of Health Sciences and Technology, University of Oulu, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Department of Diagnostic Radiology, Oulu University Hospital – sequence: 21 givenname: Ari orcidid: 0000-0002-3681-9953 surname: Heinonen fullname: Heinonen, Ari organization: Faculty of Sport and Health Sciences, University of Jyväskylä |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40551179$$D View this record in MEDLINE/PubMed |
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| Keywords | Knee Cartilage Subchondral bone Osteoarthritis Exercise therapy |
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| Snippet | Background
Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among... Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the core... Background Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among... BackgroundKnee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is among the... Abstract Background Knee osteoarthritis (KOA) is considered a whole-joint disease that is amenable to prevention and treatment in the early stages. Exercise is... |
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| SubjectTerms | Aged Biomedicine Bones Care and treatment Cartilage Cartilage, Articular - diagnostic imaging Cartilage, Articular - physiopathology Clinical trials Data collection Density Disease Exercise Exercise therapy Exercise Therapy - methods Female Health Sciences Humans Knee Knee Joint - diagnostic imaging Knee Joint - physiopathology Magnetic Resonance Imaging Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Morphology Osteoarthritis Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - physiopathology Osteoarthritis, Knee - rehabilitation Osteoarthritis, Knee - therapy Osteoporosis Physical fitness Postmenopausal women Postmenopause Questionnaires Randomized Controlled Trials as Topic Range of motion Resistance Training Statistics for Life Sciences Steroids Study Protocol Subchondral bone Time Factors Treatment Outcome Womens health |
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| Title | Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial |
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| Volume | 26 |
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