Dysregulation of ubiquitin ligases in cancer

Ubiquitin ligases (UBLs) are critical components of the ubiquitin proteasome system (UPS), which governs fundamental processes regulating normal cellular homeostasis, metabolism, and cell cycle in response to external stress signals and DNA damage. Among multiple steps of the UPS system required to...

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Bibliographic Details
Published in:	Drug resistance updates Vol. 23; pp. 1 - 11
Main Authors:	Qi, Jianfei, Ronai, Ze’ev A.
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01.11.2015
Subjects:	Antineoplastic Agents - therapeutic use Cell Cycle - genetics Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Epigenesis, Genetic Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Infectious Disease Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncogene Proteins - genetics Oncogene Proteins - metabolism Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational Proteolysis Signal Transduction Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin - genetics Ubiquitin - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
ISSN:	1368-7646, 1532-2084, 1532-2084
Online Access:	Get full text
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