Contribution of Chronic Sleep Deprivation to Age-Related Neurodegeneration in a Mouse Model of Familial Alzheimer’s Disease (5xFAD)

Sleep–wake cycle disorders most often accompany the elderly and are frequently associated with the development of neurodegenerative processes, primarily Alzheimer’s disease. Sleep disturbances can be diagnosed in patients with AD even before the onset of memory and cognitive impairment, and become m...

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Vydané v:	Neurology international Ročník 15; číslo 3; s. 778 - 791
Hlavní autori:	Klimenko, Maria O., Mishchenko, Tatiana A., Mitaeva, Yaroslava I., Kondakova, Elena V., Mitroshina, Elena V., Vedunova, Maria V.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 27.06.2023 MDPI
Predmet:	5xFAD mice Age groups aging Alzheimer's disease behavior Brain Cognition & reasoning DNA methylation Insomnia Memory Mitochondria Mutation Neurodegeneration Sleep deprivation Sleep disorders Urination Spain sleep deprivation memory Alzheimer’s disease 5xFAD mice neurodegeneration aging behavior
ISSN:	2035-8377, 2035-8385, 2035-8377
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Abstract	Sleep–wake cycle disorders most often accompany the elderly and are frequently associated with the development of neurodegenerative processes, primarily Alzheimer’s disease. Sleep disturbances can be diagnosed in patients with AD even before the onset of memory and cognitive impairment, and become more pronounced as the disease progresses. Therefore, the expansion of our knowledge of how sleep relates to AD pathogenesis needs to be addressed as soon as possible. Here, we investigated the influence of chronic sleep deprivation on the motor and orienting–exploratory activity of 5xFAD mice, as well as their spatial learning ability and long-term memory retention. The studies carried out revealed that chronic sleep deprivation negatively affects the processes of spatial memory reconsolidation in 5xFAD mice. This leads to the development of stress-related behavioral responses, including aggressive behavior. In addition, the morphological changes in the cerebral cortex, including changes in the nuclear–cytoplasmic ratio and degradation of neuronal processes are observed. Moreover, we found an increase in the level of total DNA methylation in the blood of the sleep-deprived mice, which may be one of the mechanisms of the two-way relationship between sleep and neurodegeneration.
AbstractList	Sleep–wake cycle disorders most often accompany the elderly and are frequently associated with the development of neurodegenerative processes, primarily Alzheimer’s disease. Sleep disturbances can be diagnosed in patients with AD even before the onset of memory and cognitive impairment, and become more pronounced as the disease progresses. Therefore, the expansion of our knowledge of how sleep relates to AD pathogenesis needs to be addressed as soon as possible. Here, we investigated the influence of chronic sleep deprivation on the motor and orienting–exploratory activity of 5xFAD mice, as well as their spatial learning ability and long-term memory retention. The studies carried out revealed that chronic sleep deprivation negatively affects the processes of spatial memory reconsolidation in 5xFAD mice. This leads to the development of stress-related behavioral responses, including aggressive behavior. In addition, the morphological changes in the cerebral cortex, including changes in the nuclear–cytoplasmic ratio and degradation of neuronal processes are observed. Moreover, we found an increase in the level of total DNA methylation in the blood of the sleep-deprived mice, which may be one of the mechanisms of the two-way relationship between sleep and neurodegeneration. Sleep-wake cycle disorders most often accompany the elderly and are frequently associated with the development of neurodegenerative processes, primarily Alzheimer's disease. Sleep disturbances can be diagnosed in patients with AD even before the onset of memory and cognitive impairment, and become more pronounced as the disease progresses. Therefore, the expansion of our knowledge of how sleep relates to AD pathogenesis needs to be addressed as soon as possible. Here, we investigated the influence of chronic sleep deprivation on the motor and orienting-exploratory activity of 5xFAD mice, as well as their spatial learning ability and long-term memory retention. The studies carried out revealed that chronic sleep deprivation negatively affects the processes of spatial memory reconsolidation in 5xFAD mice. This leads to the development of stress-related behavioral responses, including aggressive behavior. In addition, the morphological changes in the cerebral cortex, including changes in the nuclear-cytoplasmic ratio and degradation of neuronal processes are observed. Moreover, we found an increase in the level of total DNA methylation in the blood of the sleep-deprived mice, which may be one of the mechanisms of the two-way relationship between sleep and neurodegeneration.Sleep-wake cycle disorders most often accompany the elderly and are frequently associated with the development of neurodegenerative processes, primarily Alzheimer's disease. Sleep disturbances can be diagnosed in patients with AD even before the onset of memory and cognitive impairment, and become more pronounced as the disease progresses. Therefore, the expansion of our knowledge of how sleep relates to AD pathogenesis needs to be addressed as soon as possible. Here, we investigated the influence of chronic sleep deprivation on the motor and orienting-exploratory activity of 5xFAD mice, as well as their spatial learning ability and long-term memory retention. The studies carried out revealed that chronic sleep deprivation negatively affects the processes of spatial memory reconsolidation in 5xFAD mice. This leads to the development of stress-related behavioral responses, including aggressive behavior. In addition, the morphological changes in the cerebral cortex, including changes in the nuclear-cytoplasmic ratio and degradation of neuronal processes are observed. Moreover, we found an increase in the level of total DNA methylation in the blood of the sleep-deprived mice, which may be one of the mechanisms of the two-way relationship between sleep and neurodegeneration.
Author	Klimenko, Maria O. Mishchenko, Tatiana A. Vedunova, Maria V. Mitroshina, Elena V. Kondakova, Elena V. Mitaeva, Yaroslava I.
AuthorAffiliation	Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia
AuthorAffiliation_xml	– name: Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia
Author_xml	– sequence: 1 givenname: Maria O. surname: Klimenko fullname: Klimenko, Maria O. – sequence: 2 givenname: Tatiana A. orcidid: 0000-0003-4463-5035 surname: Mishchenko fullname: Mishchenko, Tatiana A. – sequence: 3 givenname: Yaroslava I. surname: Mitaeva fullname: Mitaeva, Yaroslava I. – sequence: 4 givenname: Elena V. orcidid: 0000-0002-6123-8181 surname: Kondakova fullname: Kondakova, Elena V. – sequence: 5 givenname: Elena V. orcidid: 0000-0003-1703-2618 surname: Mitroshina fullname: Mitroshina, Elena V. – sequence: 6 givenname: Maria V. orcidid: 0000-0001-9759-6477 surname: Vedunova fullname: Vedunova, Maria V.
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Cites_doi	10.1016/S1474-4422(18)30450-2 10.1523/JNEUROSCI.1202-06.2006 10.1016/S0091-679X(06)80001-4 10.18632/aging.203372 10.1016/j.jsmc.2017.09.002 10.1016/j.neubiorev.2021.06.039 10.1016/j.nbas.2022.100057 10.1159/000492831 10.1016/S0531-5565(98)00045-X 10.1038/373523a0 10.1158/0008-5472.CAN-15-3278 10.1074/jbc.M608485200 10.1530/JOE-17-0370 10.3389/fncel.2022.875138 10.1186/s12974-020-01960-9 10.3390/ijms24010107 10.1016/j.arr.2022.101775 10.1016/j.psyneuen.2022.105770 10.1038/s41576-018-0004-3 10.3233/JAD-220924 10.1136/jnnp-2022-330931 10.1001/jamanetworkopen.2020.13573 10.1111/jsr.13229 10.3389/fbioe.2022.895406 10.1073/pnas.1120658109 10.1111/acel.12903 10.3390/ijms21031168 10.1038/mp.2011.126 10.1523/JNEUROSCI.20-11-04050.2000 10.1002/cam4.5809 10.1016/S0140-6736(13)60630-3 10.1001/archpsyc.1975.01760240077006 10.3389/fcell.2020.00582 10.1016/j.ab.2010.02.008 10.3389/fgene.2014.00088 10.1186/s12915-015-0118-4 10.3390/nu12040936 10.1038/s41562-020-00965-x 10.1016/j.pharmthera.2013.12.009 10.1111/acel.12325
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StartPage	778
SubjectTerms	5xFAD mice Age groups aging Alzheimer's disease behavior Brain Cognition & reasoning DNA methylation Insomnia Memory Mitochondria Mutation Neurodegeneration Sleep deprivation Sleep disorders Urination
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Title	Contribution of Chronic Sleep Deprivation to Age-Related Neurodegeneration in a Mouse Model of Familial Alzheimer’s Disease (5xFAD)
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