Combination Chemotherapy in Advanced Adrenocortical Carcinoma

In this large international study of patients with adrenal cancer, a rare, treatment-refractory disease, mitotane plus a combination of etoposide, cisplatin, and doxorubicin had greater antitumor activity than mitotane plus streptozotocin. Adrenocortical carcinoma is a rare cancer (estimated inciden...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 366; no. 23; pp. 2189 - 2197
Main Authors:	Fassnacht, Martin, Terzolo, Massimo, Allolio, Bruno, Baudin, Eric, Haak, Harm, Berruti, Alfredo, Welin, Staffan, Schade-Brittinger, Carmen, Lacroix, André, Jarzab, Barbara, Sorbye, Halfdan, Torpy, David J, Stepan, Vinzenz, Schteingart, David E, Arlt, Wiebke, Kroiss, Matthias, Leboulleux, Sophie, Sperone, Paola, Sundin, Anders, Hermsen, Ilse, Hahner, Stefanie, Willenberg, Holger S, Tabarin, Antoine, Quinkler, Marcus, de la Fouchardière, Christelle, Schlumberger, Martin, Mantero, Franco, Weismann, Dirk, Beuschlein, Felix, Gelderblom, Hans, Wilmink, Hanneke, Sender, Monica, Edgerly, Maureen, Kenn, Werner, Fojo, Tito, Müller, Hans-Helge, Skogseid, Britt
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 07.06.2012
Subjects:	Adrenal Cortex Neoplasms - drug therapy Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adrenocortical Carcinoma - drug therapy Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cancer therapies Chemotherapy Cisplatin Cisplatin - administration & dosage Cytotoxicity Disease-Free Survival Doxorubicin Doxorubicin - administration & dosage Drug dosages Endocrinopathies Etoposide Etoposide - administration & dosage Female General aspects Hospitals Humans Intention to Treat Analysis Kaplan-Meier Estimate Male Malignant tumors Medical prognosis Medical sciences Metastasis Middle Aged Mitotane - administration & dosage Mitotane - adverse effects Neuroendocrine tumors Patients Population Quality of Life Response rates Streptozocin Streptozocin - administration & dosage Streptozocin - adverse effects Survival Tumors Young Adult Germany Endocrinopathy Medicine Adrenal cortex carcinoma Drug combination Adrenal gland diseases Advanced stage Combined treatment Malignant tumor Cancer
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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