Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials

Large trials have shown that sodium glucose co-transporter-2 (SGLT2) inhibitors reduce the risk of adverse kidney and cardiovascular outcomes in patients with heart failure or chronic kidney disease, or with type 2 diabetes and high risk of atherosclerotic cardiovascular disease. None of the trials...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 400; no. 10365; pp. 1788 - 1801
Main Authors:	Baigent, Colin, Emberson, JonathanR, Haynes, Richard, Herrington, William G., Judge, Parminder, Landray, Martin J., Mayne, Kaitlin J., Ng, Sarah Y.A., Preiss, David, Roddick, Alistair J., Staplin, Natalie, Zhu, Doreen, Anker, Stefan D., Bhatt, Deepak L., Brueckmann, Martina, Butler, Javed, Cherney, David Z.I., Green, Jennifer B., Hauske, Sibylle J., Heerspink, Hiddo J.L., Inzucchi, Silvio E., Jardine, Meg J., Liu, Chih-Chin, Mahaffey, Kenneth W., McCausland, Finnian R., McGuire, Darren K., McMurray, John J.V., Neal, Bruce, Neuen, Brendon L., Packer, Milton, Perkovic, Vlado, Sabatine, Marc S., Solomon, Scott D., Vaduganathan, Muthiah, Wanner, Christoph, Wheeler, David C., Wiviott, Stephen D., Zannad, Faiez
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 19.11.2022 Elsevier Limited
Subjects:	Acute Kidney Injury Adolescent Adult Amputation Arteriosclerosis Atherosclerosis Bias Cardiovascular disease Cardiovascular diseases Clinical trials Collaboration Congestive heart failure Death Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetic ketoacidosis Disease Progression Ejection fraction End-stage renal disease Epidermal growth factor receptors Glomerular filtration rate Glucose Glucose transporter Health risks Heart diseases Heart Failure Hospitalization Humans Infections Inhibitors Injury prevention Ketoacidosis Ketosis Kidney Kidney diseases Kidneys Medical research Meta-analysis Mortality Patients Placebos Randomization Randomized Controlled Trials as Topic Renal failure Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - drug therapy Risk Sodium Sodium-Glucose Transporter 2 Sodium-Glucose Transporter 2 Inhibitors - adverse effects Transplants & implants Transportation safety Variance analysis
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
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