An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimens...

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Vydané v:Cell reports. Medicine Ročník 3; číslo 2; s. 100525
Hlavní autori: Johnson, Brett E., Creason, Allison L., Stommel, Jayne M., Keck, Jamie M., Parmar, Swapnil, Betts, Courtney B., Blucher, Aurora, Boniface, Christopher, Bucher, Elmar, Burlingame, Erik, Camp, Todd, Chin, Koei, Eng, Jennifer, Estabrook, Joseph, Feiler, Heidi S., Heskett, Michael B., Hu, Zhi, Kolodzie, Annette, Kong, Ben L., Labrie, Marilyne, Lee, Jinho, Leyshock, Patrick, Mitri, Souraya, Patterson, Janice, Riesterer, Jessica L., Sivagnanam, Shamilene, Somers, Julia, Sudar, Damir, Thibault, Guillaume, Weeder, Benjamin R., Zheng, Christina, Nan, Xiaolin, Thompson, Reid F., Heiser, Laura M., Spellman, Paul T., Thomas, George, Demir, Emek, Chang, Young Hwan, Coussens, Lisa M., Guimaraes, Alexander R., Corless, Christopher, Goecks, Jeremy, Bergan, Raymond, Mitri, Zahi, Mills, Gordon B., Gray, Joe W.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 15.02.2022
Elsevier
Predmet:
Advanced Basic Science
Biopsy
Breast Neoplasms - genetics
Female
human tumor atlas
Humans
metastatic breast cancer
personalized medicine
precision oncology
Tumor Microenvironment - genetics
precision oncology
human tumor atlas
metastatic breast cancer
personalized medicine
ISSN:2666-3791, 2666-3791
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Abstract Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities. [Display omitted] •Safe and reliable workflows for multiplatform measurements from single biopsies•Clinical metadata with 11 omic and imaging assays from serial biopsy and blood•Omic, cellular, and structural evolution of metastatic cancer in a single individual•Integrative analyses reveal new potential mechanisms of response and resistance Identifying mechanisms of response and resistance to treatment in individual cancer patients is challenging but critical for improvement of precision medicine outcomes. Johnson et al. report a comprehensive atlas from a single individual with breast cancer and demonstrate how longitudinal, integrative analyses can provide new insights.
AbstractList Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities.Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities.
Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities.
Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities. [Display omitted] •Safe and reliable workflows for multiplatform measurements from single biopsies•Clinical metadata with 11 omic and imaging assays from serial biopsy and blood•Omic, cellular, and structural evolution of metastatic cancer in a single individual•Integrative analyses reveal new potential mechanisms of response and resistance Identifying mechanisms of response and resistance to treatment in individual cancer patients is challenging but critical for improvement of precision medicine outcomes. Johnson et al. report a comprehensive atlas from a single individual with breast cancer and demonstrate how longitudinal, integrative analyses can provide new insights.
SummaryMechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities.
Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities. • Safe and reliable workflows for multiplatform measurements from single biopsies • Clinical metadata with 11 omic and imaging assays from serial biopsy and blood • Omic, cellular, and structural evolution of metastatic cancer in a single individual • Integrative analyses reveal new potential mechanisms of response and resistance Identifying mechanisms of response and resistance to treatment in individual cancer patients is challenging but critical for improvement of precision medicine outcomes. Johnson et al. report a comprehensive atlas from a single individual with breast cancer and demonstrate how longitudinal, integrative analyses can provide new insights.
ArticleNumber 100525
Author Kong, Ben L.
Demir, Emek
Stommel, Jayne M.
Lee, Jinho
Coussens, Lisa M.
Thibault, Guillaume
Sivagnanam, Shamilene
Thomas, George
Keck, Jamie M.
Mitri, Zahi
Labrie, Marilyne
Zheng, Christina
Chin, Koei
Thompson, Reid F.
Corless, Christopher
Blucher, Aurora
Creason, Allison L.
Heiser, Laura M.
Weeder, Benjamin R.
Chang, Young Hwan
Boniface, Christopher
Riesterer, Jessica L.
Burlingame, Erik
Mills, Gordon B.
Eng, Jennifer
Leyshock, Patrick
Somers, Julia
Spellman, Paul T.
Guimaraes, Alexander R.
Patterson, Janice
Sudar, Damir
Mitri, Souraya
Johnson, Brett E.
Goecks, Jeremy
Bergan, Raymond
Bucher, Elmar
Parmar, Swapnil
Camp, Todd
Heskett, Michael B.
Feiler, Heidi S.
Nan, Xiaolin
Hu, Zhi
Kolodzie, Annette
Estabrook, Joseph
Gray, Joe W.
Betts, Courtney B.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35243422$$D View this record in MEDLINE/PubMed
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Keywords precision oncology
human tumor atlas
metastatic breast cancer
personalized medicine
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Snippet Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during...
SummaryMechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change...
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SubjectTerms Advanced Basic Science
Biopsy
Breast Neoplasms - genetics
Female
human tumor atlas
Humans
metastatic breast cancer
personalized medicine
precision oncology
Tumor Microenvironment - genetics
Title An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer
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