Cytomegalovirus primo-infection in Guillain-Barré syndrome during pregnancy, a case report of a very serious and rare case

Background Guillain-Barré syndrome (GBS) during pregnancy can be a very severe and life-threatening condition for both mother and child. GBS due to cytomegalovirus (CMV) in pregnancy is even rarer and may be associated with more respiratory insufficiency, cranial nerve involvement and sensory loss i...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	BMC neurology Ročník 25; číslo 1; s. 224 - 5
Hlavní autoři:	Hänsel, Martin, Kalimeris, Stylianos, Schreiner, Bettina, Friedl, Susanne, Cannizzaro, Vincenzo, Keller, Emanuela, Haslinger, Christian, Brandi, Giovanna
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 26.05.2025 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Adult Apheresis Case Report Case reports Case studies Cerebrospinal fluid Cesarean section CMV Cranial nerves Cytomegalovirus Cytomegalovirus infections Cytomegalovirus Infections - complications Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - therapy Demyelination Diagnosis Facial paralysis Female Fetuses GBS Guillain-Barre syndrome Guillain-Barre Syndrome - complications Guillain-Barre Syndrome - diagnosis Guillain-Barre Syndrome - therapy Guillain-Barre Syndrome - virology Guillain-Barré syndrome Health aspects Humans Hyperventilation Immunoglobulins Infection Infections Intensive care Interdisciplinary aspects Mechanical ventilation Medical research Medicine Medicine & Public Health Medicine, Experimental Morbidity Muscle strength Neurochemistry Neurology Neurosurgery Ostomy Paralysis Paresis Patients Pneumonia Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - therapy Pregnancy, Complications of Pregnant women Respiratory failure Tracheotomy Ultrasonic imaging Ventilators Switzerland Pregnancy Cytomegalovirus GBS CMV Guillain-Barré syndrome
ISSN:	1471-2377, 1471-2377
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Background Guillain-Barré syndrome (GBS) during pregnancy can be a very severe and life-threatening condition for both mother and child. GBS due to cytomegalovirus (CMV) in pregnancy is even rarer and may be associated with more respiratory insufficiency, cranial nerve involvement and sensory loss in the mother. Case presentation A 29-year-old secondparous woman at 25 weeks of gestation (WG) presented with a rapid ascending tetraparesis, bulbar paralysis, bilateral facial palsy, right-sided abducens paresis within 72 h of symptom onset and respiratory failure after 12 days. She needed intubation and mechanical ventilation for cumulative 42 days. GBS due to CMV primo-infection was diagnosed. A multidisciplinary team was involved to monitor and manage patient and fetus. In the electrodiagnostic studies, the patient presented severe primarily demyelinating features consistent with an acute inflammatory demyelinating (AIDP) GBS form treated with repeated plasma exchanges and administration of intravenous immunoglobulins. At 34 + 1 WG a cesarean delivery was performed, the newborn was healthy without intrauterine CMV-transmission. Conclusion The optimal time of delivery for intubated pregnant GBS patients is unknown. The mother’s respiratory and medical conditions should be assessed in relation to premature-associated morbidity of the newborn.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Report-3 ObjectType-Case Study-4 content type line 23
ISSN:	1471-2377 1471-2377
DOI:	10.1186/s12883-025-04233-1