Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis

We aimed at investigating the role of 14q32 microRNAs in intimal hyperplasia and accelerated atherosclerosis; two major contributors to restenosis. Restenosis occurs regularly in patients treated for coronary artery disease and peripheral arterial disease. We have previously shown that inhibition of...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 261; pp. 26 - 36
Main Authors:	Welten, Sabine M.J., de Jong, Rob C.M., Wezel, Anouk, de Vries, Margreet R., Boonstra, Martin C., Parma, Laura, Jukema, J. Wouter, van der Sluis, Tetje C., Arens, Ramon, Bot, Ilze, Agrawal, Sudhir, Quax, Paul H.A., Nossent, A. Yaël
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01.06.2017
Subjects:	14q32 Accelerated atherosclerosis Animals Biomarkers - blood Cardiovascular Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Artery Diseases - blood Carotid Artery Diseases - genetics Carotid Artery Diseases - pathology Carotid Artery Diseases - prevention & control Cell Proliferation Cells, Cultured Cholesterol - blood Disease Models, Animal Femoral Artery - metabolism Femoral Artery - pathology Gene Silencing Hypercholesterolemia - blood Hypercholesterolemia - genetics Hypercholesterolemia - prevention & control Hyperplasia Macrophages - metabolism Macrophages - pathology Male Mice, Inbred C57BL Mice, Knockout, ApoE microRNA MicroRNAs - genetics MicroRNAs - metabolism Neointima Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - genetics Peripheral Arterial Disease - blood Peripheral Arterial Disease - genetics Peripheral Arterial Disease - pathology Peripheral Arterial Disease - prevention & control Plaque, Atherosclerotic Recurrence Restenosis Vascular Remodeling Restenosis microRNA Accelerated atherosclerosis 14q32
ISSN:	0021-9150, 1879-1484, 1879-1484
Online Access:	Get full text
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