Retrospective comparison of chemoradiotherapy followed by adjuvant chemotherapy, with or without prior gliadel implantation (carmustine) after initial surgery in patients with newly diagnosed high-grade gliomas

Retrospective study of patients treated for high-grade glioma, with or without biodegradable carmustine wafers and according to the Stupp protocol. Between May 2007 and June 2008, 65 patients underwent surgery for high-grade glioma, 28 had implantation of Gliadel and 37 patients did not. Patients re...

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Vydáno v:	International journal of radiation oncology, biology, physics Ročník 82; číslo 2; s. 749
Hlavní autoři:	Noël, Georges, Schott, Roland, Froelich, Sébastien, Gaub, Marie-Pierre, Boyer, Patrick, Fischer-Lokou, David, Dufour, Patrick, Kehrli, Pierre, Maitrot, Daniel
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.02.2012
Témata:	Adolescent Adult Aged Aged, 80 and over Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Astrocytoma - mortality Astrocytoma - pathology Astrocytoma - surgery Astrocytoma - therapy Brain Neoplasms - mortality Brain Neoplasms - pathology Brain Neoplasms - surgery Brain Neoplasms - therapy Carmustine - administration & dosage Carmustine - adverse effects Chemoradiotherapy - methods Chemotherapy, Adjuvant - adverse effects Chemotherapy, Adjuvant - methods Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use Disease-Free Survival DNA Modification Methylases - metabolism DNA Repair Enzymes - metabolism Female Glioblastoma - mortality Glioblastoma - pathology Glioblastoma - surgery Glioblastoma - therapy Humans Male Middle Aged Neoplasm Proteins - metabolism Retrospective Studies Survival Analysis Thrombocytopenia - etiology Tumor Burden Tumor Suppressor Proteins - metabolism Young Adult
ISSN:	1879-355X, 1879-355X
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