Creation of a bacterial cell controlled by a chemically synthesized genome
We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic ch...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 329; no. 5987; p. 52 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
02.07.2010
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| Subjects: | |
| ISSN: | 1095-9203, 1095-9203 |
| Online Access: | Get more information |
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| Abstract | We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic chromosome. The only DNA in the cells is the designed synthetic DNA sequence, including "watermark" sequences and other designed gene deletions and polymorphisms, and mutations acquired during the building process. The new cells have expected phenotypic properties and are capable of continuous self-replication. |
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| AbstractList | We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic chromosome. The only DNA in the cells is the designed synthetic DNA sequence, including "watermark" sequences and other designed gene deletions and polymorphisms, and mutations acquired during the building process. The new cells have expected phenotypic properties and are capable of continuous self-replication. We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic chromosome. The only DNA in the cells is the designed synthetic DNA sequence, including "watermark" sequences and other designed gene deletions and polymorphisms, and mutations acquired during the building process. The new cells have expected phenotypic properties and are capable of continuous self-replication.We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic chromosome. The only DNA in the cells is the designed synthetic DNA sequence, including "watermark" sequences and other designed gene deletions and polymorphisms, and mutations acquired during the building process. The new cells have expected phenotypic properties and are capable of continuous self-replication. |
| Author | Qi, Zhi-Qing Calvey, Christopher H Venter, J Craig Merryman, Chuck Noskov, Vladimir N Vashee, Sanjay Assad-Garcia, Nacyra Gibson, Daniel G Lartigue, Carole Young, Lei Parmar, Prashanth P Smith, Hamilton O Hutchison, 3rd, Clyde A Algire, Mikkel A Benders, Gwynedd A Segall-Shapiro, Thomas H Ma, Li Moodie, Monzia M Krishnakumar, Radha Denisova, Evgeniya A Glass, John I Chuang, Ray-Yuan Montague, Michael G Andrews-Pfannkoch, Cynthia |
| Author_xml | – sequence: 1 givenname: Daniel G surname: Gibson fullname: Gibson, Daniel G organization: The J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA – sequence: 2 givenname: John I surname: Glass fullname: Glass, John I – sequence: 3 givenname: Carole surname: Lartigue fullname: Lartigue, Carole – sequence: 4 givenname: Vladimir N surname: Noskov fullname: Noskov, Vladimir N – sequence: 5 givenname: Ray-Yuan surname: Chuang fullname: Chuang, Ray-Yuan – sequence: 6 givenname: Mikkel A surname: Algire fullname: Algire, Mikkel A – sequence: 7 givenname: Gwynedd A surname: Benders fullname: Benders, Gwynedd A – sequence: 8 givenname: Michael G surname: Montague fullname: Montague, Michael G – sequence: 9 givenname: Li surname: Ma fullname: Ma, Li – sequence: 10 givenname: Monzia M surname: Moodie fullname: Moodie, Monzia M – sequence: 11 givenname: Chuck surname: Merryman fullname: Merryman, Chuck – sequence: 12 givenname: Sanjay surname: Vashee fullname: Vashee, Sanjay – sequence: 13 givenname: Radha surname: Krishnakumar fullname: Krishnakumar, Radha – sequence: 14 givenname: Nacyra surname: Assad-Garcia fullname: Assad-Garcia, Nacyra – sequence: 15 givenname: Cynthia surname: Andrews-Pfannkoch fullname: Andrews-Pfannkoch, Cynthia – sequence: 16 givenname: Evgeniya A surname: Denisova fullname: Denisova, Evgeniya A – sequence: 17 givenname: Lei surname: Young fullname: Young, Lei – sequence: 18 givenname: Zhi-Qing surname: Qi fullname: Qi, Zhi-Qing – sequence: 19 givenname: Thomas H surname: Segall-Shapiro fullname: Segall-Shapiro, Thomas H – sequence: 20 givenname: Christopher H surname: Calvey fullname: Calvey, Christopher H – sequence: 21 givenname: Prashanth P surname: Parmar fullname: Parmar, Prashanth P – sequence: 22 givenname: Clyde A surname: Hutchison, 3rd fullname: Hutchison, 3rd, Clyde A – sequence: 23 givenname: Hamilton O surname: Smith fullname: Smith, Hamilton O – sequence: 24 givenname: J Craig surname: Venter fullname: Venter, J Craig |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20488990$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Bacterial Proteins - analysis Base Sequence Bioengineering Cloning, Molecular DNA, Bacterial - chemical synthesis DNA, Bacterial - genetics Escherichia coli - genetics Gene Deletion Genes, Bacterial Genetic Engineering Genome, Bacterial Molecular Sequence Data Mycoplasma capricolum - genetics Mycoplasma mycoides - genetics Mycoplasma mycoides - growth & development Mycoplasma mycoides - physiology Mycoplasma mycoides - ultrastructure Phenotype Plasmids Polymerase Chain Reaction Polymorphism, Genetic Saccharomyces cerevisiae - genetics Transformation, Bacterial |
| Title | Creation of a bacterial cell controlled by a chemically synthesized genome |
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