Role of the Fas/FasL Pathway in HIV or SIV Disease

Human immunodeficiency virus disease involves progressive destruction of host immunity leading to opportunistic infections and increased rates for malignancies. Quantitative depletion of immune cell subsets and accruing defects in cell effector functions are together responsible for immunodeficiency...

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Bibliographic Details
Published in:Retrovirology Vol. 6; no. 1; p. 91
Main Authors: Poonia, Bhawna, Pauza, C David, Salvato, Maria S
Format: Journal Article
Language:English
Published: London BioMed Central 15.10.2009
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Acquired immune deficiency syndrome
AIDS
Animals
Antibodies
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell Death
Cellular signal transduction
Development and progression
Fas Ligand Protein - physiology
fas Receptor - physiology
Genetic aspects
Haplorhini
HIV
HIV - pathogenicity
HIV infection
HIV Infections - virology
Human immunodeficiency virus
Humans
Infectious Diseases
Models, Biological
Physiological aspects
Protein Structure
Proteins
Review
Simian Acquired Immunodeficiency Syndrome - virology
Simian immunodeficiency virus
Simian Immunodeficiency Virus - pathogenicity
T cell receptors
Vaccine
Virology
United States
Cell Depletion
Uninfected Cell
Plasma Viremia
Chronic Immune Activation
Viral Burden
ISSN:1742-4690, 1742-4690
Online Access:Get full text
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Summary:Human immunodeficiency virus disease involves progressive destruction of host immunity leading to opportunistic infections and increased rates for malignancies. Quantitative depletion of immune cell subsets and accruing defects in cell effector functions are together responsible for immunodeficiency The broad impact of HIV reflects a similarly broad spectrum of affected cells including subsets that do not express viral receptors or support viral replication. Indirect cell killing, the destruction of uninfected cells, is one important mechanism due partly to activation of the Fas/FasL system for cell death. This death-signaling pathway is induced during HIV disease and contributes significantly to viral pathogenesis and disease.
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ISSN:1742-4690
1742-4690
DOI:10.1186/1742-4690-6-91