Role of the Fas/FasL Pathway in HIV or SIV Disease

Human immunodeficiency virus disease involves progressive destruction of host immunity leading to opportunistic infections and increased rates for malignancies. Quantitative depletion of immune cell subsets and accruing defects in cell effector functions are together responsible for immunodeficiency...

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Vydané v:	Retrovirology Ročník 6; číslo 1; s. 91
Hlavní autori:	Poonia, Bhawna, Pauza, C David, Salvato, Maria S
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 15.10.2009 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Acquired immune deficiency syndrome AIDS Animals Antibodies Apoptosis Biomedical and Life Sciences Biomedicine Cancer Research Cell Death Cellular signal transduction Development and progression Fas Ligand Protein - physiology fas Receptor - physiology Genetic aspects Haplorhini HIV HIV - pathogenicity HIV infection HIV Infections - virology Human immunodeficiency virus Humans Infectious Diseases Models, Biological Physiological aspects Protein Structure Proteins Review Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - pathogenicity T cell receptors Vaccine Virology United States Cell Depletion Uninfected Cell Plasma Viremia Chronic Immune Activation Viral Burden
ISSN:	1742-4690, 1742-4690
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Popis
Shrnutí:	Human immunodeficiency virus disease involves progressive destruction of host immunity leading to opportunistic infections and increased rates for malignancies. Quantitative depletion of immune cell subsets and accruing defects in cell effector functions are together responsible for immunodeficiency The broad impact of HIV reflects a similarly broad spectrum of affected cells including subsets that do not express viral receptors or support viral replication. Indirect cell killing, the destruction of uninfected cells, is one important mechanism due partly to activation of the Fas/FasL system for cell death. This death-signaling pathway is induced during HIV disease and contributes significantly to viral pathogenesis and disease.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1742-4690 1742-4690
DOI:	10.1186/1742-4690-6-91