Mechanisms linking obesity to hypertension

Obesity‐related hypertension is increasingly recognized as a distinct hypertensive phenotype requiring a modified approach to diagnosis and management. In this review rapidly evolving insights into the complex and interdependent mechanisms linking obesity to hypertension are discussed. Overweight an...

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Vydáno v:Obesity reviews Ročník 13; číslo 1; s. 17 - 26
Hlavní autoři: Dorresteijn, J. A. N, Visseren, F. L. J, Spiering, W
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.01.2012
Témata:
adipocytes
Adipocytes - cytology
adipokines
adipose tissue
Antihypertensive Agents
Antihypertensive Agents - therapeutic use
blood
complications
cytology
drug therapy
drugs
etiology
free fatty acids
Health Behavior
Humans
Hypertension
Hypertension - drug therapy
Hypertension - etiology
Hypertension - prevention & control
inflammation
Life Style
lifestyle
macrophages
metabolic syndrome
obesity
Obesity - complications
obesity-related hypertension
oxidative stress
Oxidative Stress - physiology
phenotype
physiology
prevention & control
Renin-Angiotensin System
Renin-Angiotensin System - physiology
secretion
therapeutic use
Weight Loss
Weight Loss - physiology
ISSN:1467-7881, 1467-789X, 1467-789X
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Popis
Shrnutí:Obesity‐related hypertension is increasingly recognized as a distinct hypertensive phenotype requiring a modified approach to diagnosis and management. In this review rapidly evolving insights into the complex and interdependent mechanisms linking obesity to hypertension are discussed. Overweight and obesity are associated with adipose tissue dysfunction, characterized by enlarged hypertrophied adipocytes, increased infiltration by macrophages and marked changes in secretion of adipokines and free fatty acids. This results in chronic vascular inflammation, oxidative stress, activation of the renin‐angiotensin‐aldosterone system and sympathetic overdrive, eventually leading to hypertension. These mechanisms may provide novel targets for anti‐hypertensive drug treatment. Recognition of obesity‐related hypertension as a distinct diagnosis enables tailored therapy in clinical practice. This includes lifestyle modification and accommodated choice of blood pressure‐lowering drugs.
Bibliografie:http://dx.doi.org/10.1111/j.1467-789X.2011.00914.x
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ObjectType-Article-2
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ISSN:1467-7881
1467-789X
1467-789X
DOI:10.1111/j.1467-789X.2011.00914.x