Pattern recognition receptors and the inflammasome in kidney disease

Key Points Toll-like receptors (TLRs), nucleotide-binding oligomerization domain receptors (NLRs) and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome regulate inflammatory and repair processes in the kidneys TLRs prevent invasion and growth of pathogens in the urinary tract...

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Published in:Nature reviews. Nephrology Vol. 10; no. 7; pp. 398 - 414
Main Authors: Leemans, Jaklien C., Kors, Lotte, Anders, Hans-Joachim, Florquin, Sandrine
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.07.2014
Nature Publishing Group
Subjects:
692/420/254
692/420/256
692/699/1585/1681
692/699/1585/4
Acute Kidney Injury - microbiology
Acute Kidney Injury - physiopathology
Adaptor Proteins, Signal Transducing - physiology
Animals
Carrier Proteins - immunology
Cell receptors
Cytokines
Development and progression
Genetic aspects
Homeostasis
Humans
Immune response
Infections
Inflammasomes - immunology
Inflammation
Kidney - immunology
Kidney diseases
Kidney Diseases - immunology
Kidney Transplantation
Kinases
Medical research
Medicine & Public Health
Medicine, Experimental
Mice
Nephrology
NLR Family, Pyrin Domain-Containing 3 Protein
Pathogens
Pathology
Pattern recognition
Properties
Proteins
Receptors, Pattern Recognition - immunology
review-article
Sepsis - complications
Toll-Like Receptors - genetics
Toll-Like Receptors - immunology
Urinary Tract Infections - immunology
Urogenital system
ISSN:1759-5061, 1759-507X, 1759-507X
Online Access:Get full text
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Abstract Key Points Toll-like receptors (TLRs), nucleotide-binding oligomerization domain receptors (NLRs) and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome regulate inflammatory and repair processes in the kidneys TLRs prevent invasion and growth of pathogens in the urinary tract Inappropriate activation of TLRs, NLRs and the NLRP3 inflammasome is a major cause of acute and chronic kidney disease Gene-association studies have revealed connections between TLR gene mutations and the development of several inflammatory kidney disorders TLRs, NLRs and the NLRP3 inflammasome represent attractive novel drug targets to prevent and intervene in kidney inflammation and suppress immunopathology in kidney disease In this Review, the authors discuss the pathological mechanisms related to Toll-like receptors, nucleotide-binding oligomerization domain receptors and the NACHT, LRR and PYD domains-containing protein 3 inflammasome in various kidney diseases. Although these receptors are protective in the host defence against urinary tract infection, they can perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases—making them promising drug targets. Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen motifs and endogenous molecules released upon cell damage or stress. Evidence suggests that TLRs, NLRs and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome have important roles in kidney diseases through regulation of inflammatory and tissue-repair responses to infection and injury. In this Review, we discuss the pathological mechanisms that are related to TLRs, NLRs and NLRP3 in various kidney diseases. In general, these receptors are protective in the host defence against urinary tract infection, but can sustain and self-perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases. TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease.
AbstractList Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen motifs and endogenous molecules released upon cell damage or stress. Evidence suggests that TLRs, NLRs and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome have important roles in kidney diseases through regulation of inflammatory and tissue-repair responses to infection and injury. In this Review, we discuss the pathological mechanisms that are related to TLRs, NLRs and NLRP3 in various kidney diseases. In general, these receptors are protective in the host defence against urinary tract infection, but can sustain and self-perpetuate tissue damage in sterile inflammatory and immunemediated kidney diseases. TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease. doi: 10.1038/nrneph.2014.91
Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen motifs and endogenous molecules released upon cell damage or stress. Evidence suggests that TLRs, NLRs and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome have important roles in kidney diseases through regulation of inflammatory and tissue-repair responses to infection and injury. In this Review, we discuss the pathological mechanisms that are related to TLRs, NLRs and NLRP3 in various kidney diseases. In general, these receptors are protective in the host defence against urinary tract infection, but can sustain and self-perpetuate tissue damage in sterile inflammatory and immunemediated kidney diseases. TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease.
Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen motifs and endogenous molecules released upon cell damage or stress. Evidence suggests that TLRs, NLRs and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome have important roles in kidney diseases through regulation of inflammatory and tissue-repair responses to infection and injury. In this Review, we discuss the pathological mechanisms that are related to TLRs, NLRs and NLRP3 in various kidney diseases. In general, these receptors are protective in the host defence against urinary tract infection, but can sustain and self-perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases. TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease.Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen motifs and endogenous molecules released upon cell damage or stress. Evidence suggests that TLRs, NLRs and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome have important roles in kidney diseases through regulation of inflammatory and tissue-repair responses to infection and injury. In this Review, we discuss the pathological mechanisms that are related to TLRs, NLRs and NLRP3 in various kidney diseases. In general, these receptors are protective in the host defence against urinary tract infection, but can sustain and self-perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases. TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease.
Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen motifs and endogenous molecules released upon cell damage or stress. Evidence suggests that TLRs, NLRs and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome have important roles in kidney diseases through regulation of inflammatory and tissue-repair responses to infection and injury. In this Review, we discuss the pathological mechanisms that are related to TLRs, NLRs and NLRP3 in various kidney diseases. In general, these receptors are protective in the host defence against urinary tract infection, but can sustain and self-perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases. TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease.
Key Points Toll-like receptors (TLRs), nucleotide-binding oligomerization domain receptors (NLRs) and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome regulate inflammatory and repair processes in the kidneys TLRs prevent invasion and growth of pathogens in the urinary tract Inappropriate activation of TLRs, NLRs and the NLRP3 inflammasome is a major cause of acute and chronic kidney disease Gene-association studies have revealed connections between TLR gene mutations and the development of several inflammatory kidney disorders TLRs, NLRs and the NLRP3 inflammasome represent attractive novel drug targets to prevent and intervene in kidney inflammation and suppress immunopathology in kidney disease In this Review, the authors discuss the pathological mechanisms related to Toll-like receptors, nucleotide-binding oligomerization domain receptors and the NACHT, LRR and PYD domains-containing protein 3 inflammasome in various kidney diseases. Although these receptors are protective in the host defence against urinary tract infection, they can perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases—making them promising drug targets. Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen motifs and endogenous molecules released upon cell damage or stress. Evidence suggests that TLRs, NLRs and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome have important roles in kidney diseases through regulation of inflammatory and tissue-repair responses to infection and injury. In this Review, we discuss the pathological mechanisms that are related to TLRs, NLRs and NLRP3 in various kidney diseases. In general, these receptors are protective in the host defence against urinary tract infection, but can sustain and self-perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases. TLRs, NLRs and NLRP3, therefore, have become promising drug targets to enable specific modulation of kidney inflammation and suppression of immunopathology in kidney disease.
Audience Academic
Author Kors, Lotte
Florquin, Sandrine
Anders, Hans-Joachim
Leemans, Jaklien C.
Author_xml – sequence: 1
  givenname: Jaklien C.
  surname: Leemans
  fullname: Leemans, Jaklien C.
  email: j.c.leemans@amc.uva.nl
  organization: Department of Pathology, Academic Medical Center
– sequence: 2
  givenname: Lotte
  surname: Kors
  fullname: Kors, Lotte
  organization: Department of Pathology, Academic Medical Center
– sequence: 3
  givenname: Hans-Joachim
  surname: Anders
  fullname: Anders, Hans-Joachim
  organization: Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München
– sequence: 4
  givenname: Sandrine
  surname: Florquin
  fullname: Florquin, Sandrine
  organization: Department of Pathology, Academic Medical Center
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24890433$$D View this record in MEDLINE/PubMed
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Snippet Key Points Toll-like receptors (TLRs), nucleotide-binding oligomerization domain receptors (NLRs) and the NACHT, LRR and PYD domains-containing protein 3...
Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with...
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StartPage 398
SubjectTerms 692/420/254
692/420/256
692/699/1585/1681
692/699/1585/4
Acute Kidney Injury - microbiology
Acute Kidney Injury - physiopathology
Adaptor Proteins, Signal Transducing - physiology
Animals
Carrier Proteins - immunology
Cell receptors
Cytokines
Development and progression
Genetic aspects
Homeostasis
Humans
Immune response
Infections
Inflammasomes - immunology
Inflammation
Kidney - immunology
Kidney diseases
Kidney Diseases - immunology
Kidney Transplantation
Kinases
Medical research
Medicine & Public Health
Medicine, Experimental
Mice
Nephrology
NLR Family, Pyrin Domain-Containing 3 Protein
Pathogens
Pathology
Pattern recognition
Properties
Proteins
Receptors, Pattern Recognition - immunology
review-article
Sepsis - complications
Toll-Like Receptors - genetics
Toll-Like Receptors - immunology
Urinary Tract Infections - immunology
Urogenital system
Title Pattern recognition receptors and the inflammasome in kidney disease
URI https://link.springer.com/article/10.1038/nrneph.2014.91
https://www.ncbi.nlm.nih.gov/pubmed/24890433
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