Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

Extracellular vesicles (EVs), including exosomes, have an important role thanks to their ability to communicate and exchange information between tumor cells and the tumor microenvironment (TME), and have also been associated with communicating anti-cancer drug resistance (DR). The increase in prolif...

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Vydáno v:Molecules (Basel, Switzerland) Ročník 28; číslo 1; s. 116
Hlavní autoři: Cariello, Mariaconcetta, Squilla, Angela, Piacente, Martina, Venutolo, Giorgia, Fasano, Alessio
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 23.12.2022
MDPI
Témata:
Adipocytes
Blood cancer
Cancer
Cancer therapies
Cell Communication
Cell organelles
Communication
Cytokines
Disease
Drug resistance
Drug Resistance, Neoplasm - genetics
Drug therapy
exosomes
Exosomes - genetics
Extracellular vesicles
Genetic aspects
Genotype & phenotype
Health aspects
Hematologic Neoplasms - drug therapy
Hematologic Neoplasms - genetics
Hematology
Humans
hypoxia
Kinases
Leukemia
Lymphoma
Lymphomas
MicroRNA
MicroRNAs - genetics
miRNAs
Mortality
Multiple myeloma
Oncology, Experimental
Review
Stem cells
tumor microenvironment
Tumor Microenvironment - genetics
Tumors
Italy
United States > US
hypoxia
drug resistance
tumor microenvironment
miRNAs
exosomes
ISSN:1420-3049, 1420-3049
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Popis
Shrnutí:Extracellular vesicles (EVs), including exosomes, have an important role thanks to their ability to communicate and exchange information between tumor cells and the tumor microenvironment (TME), and have also been associated with communicating anti-cancer drug resistance (DR). The increase in proliferation of cancer cells alters oxygen levels, which causes hypoxia and results in a release of exosomes by the cancer cells. In this review, the results of studies examining the role of exosomal miRNA in DR, and their mechanism, are discussed in detail in hematological tumors: leukemia, lymphoma, and multiple myeloma. In conclusion, we underline the exosome’s function as a possible drug delivery vehicle by understanding its cargo. Engineered exosomes can be used to be more specific for personalized therapy.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28010116