Image-Derived Input Function Derived from a Supervised Clustering Algorithm: Methodology and Validation in a Clinical Protocol Using [11C](R)-Rolipram
Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [(11)C](R)-rolipram positron emission tomography (PET) scans. However, manual-IDIF is time consuming and subject to inter- and intra-operator variability. To overcome this limitati...
Gespeichert in:
| Veröffentlicht in: | PloS one Jg. 9; H. 2; S. e89101 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
Public Library of Science
20.02.2014
Public Library of Science (PLoS) |
| Schlagworte: | |
| ISSN: | 1932-6203, 1932-6203 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [(11)C](R)-rolipram positron emission tomography (PET) scans. However, manual-IDIF is time consuming and subject to inter- and intra-operator variability. To overcome this limitation, we developed a fully automated technique for deriving IDIF with a supervised clustering algorithm (SVCA). To validate this technique, 25 healthy controls and 26 patients with moderate to severe major depressive disorder (MDD) underwent T1-weighted brain magnetic resonance imaging (MRI) and a 90-minute [(11)C](R)-rolipram PET scan. For each subject, metabolite-corrected input function was measured from the radial artery. SVCA templates were obtained from 10 additional healthy subjects who underwent the same MRI and PET procedures. Cluster-IDIF was obtained as follows: 1) template mask images were created for carotid and surrounding tissue; 2) parametric image of weights for blood were created using SVCA; 3) mask images to the individual PET image were inversely normalized; 4) carotid and surrounding tissue time activity curves (TACs) were obtained from weighted and unweighted averages of each voxel activity in each mask, respectively; 5) partial volume effects and radiometabolites were corrected using individual arterial data at four points. Logan-distribution volume (V T/f P) values obtained by cluster-IDIF were similar to reference results obtained using arterial data, as well as those obtained using manual-IDIF; 39 of 51 subjects had a V T/f P error of <5%, and only one had error >10%. With automatic voxel selection, cluster-IDIF curves were less noisy than manual-IDIF and free of operator-related variability. Cluster-IDIF showed widespread decrease of about 20% [(11)C](R)-rolipram binding in the MDD group. Taken together, the results suggest that cluster-IDIF is a good alternative to full arterial input function for estimating Logan-V T/f P in [(11)C](R)-rolipram PET clinical scans. This technique enables fully automated extraction of IDIF and can be applied to other radiotracers with similar kinetics. |
|---|---|
| AbstractList | Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [.sup.11 C](R)-rolipram positron emission tomography (PET) scans. However, manual-IDIF is time consuming and subject to inter- and intra-operator variability. To overcome this limitation, we developed a fully automated technique for deriving IDIF with a supervised clustering algorithm (SVCA). To validate this technique, 25 healthy controls and 26 patients with moderate to severe major depressive disorder (MDD) underwent T1-weighted brain magnetic resonance imaging (MRI) and a 90-minute [.sup.11 C](R)-rolipram PET scan. For each subject, metabolite-corrected input function was measured from the radial artery. SVCA templates were obtained from 10 additional healthy subjects who underwent the same MRI and PET procedures. Cluster-IDIF was obtained as follows: 1) template mask images were created for carotid and surrounding tissue; 2) parametric image of weights for blood were created using SVCA; 3) mask images to the individual PET image were inversely normalized; 4) carotid and surrounding tissue time activity curves (TACs) were obtained from weighted and unweighted averages of each voxel activity in each mask, respectively; 5) partial volume effects and radiometabolites were corrected using individual arterial data at four points. Logan-distribution volume (V.sub.T /f.sub.P) values obtained by cluster-IDIF were similar to reference results obtained using arterial data, as well as those obtained using manual-IDIF; 39 of 51 subjects had a V.sub.T /f.sub.P error of 10%. With automatic voxel selection, cluster-IDIF curves were less noisy than manual-IDIF and free of operator-related variability. Cluster-IDIF showed widespread decrease of about 20% [.sup.11 C](R)-rolipram binding in the MDD group. Taken together, the results suggest that cluster-IDIF is a good alternative to full arterial input function for estimating Logan-V.sub.T /f.sub.P in [.sup.11 C](R)-rolipram PET clinical scans. This technique enables fully automated extraction of IDIF and can be applied to other radiotracers with similar kinetics. Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [(11)C](R)-rolipram positron emission tomography (PET) scans. However, manual-IDIF is time consuming and subject to inter- and intra-operator variability. To overcome this limitation, we developed a fully automated technique for deriving IDIF with a supervised clustering algorithm (SVCA). To validate this technique, 25 healthy controls and 26 patients with moderate to severe major depressive disorder (MDD) underwent T1-weighted brain magnetic resonance imaging (MRI) and a 90-minute [(11)C](R)-rolipram PET scan. For each subject, metabolite-corrected input function was measured from the radial artery. SVCA templates were obtained from 10 additional healthy subjects who underwent the same MRI and PET procedures. Cluster-IDIF was obtained as follows: 1) template mask images were created for carotid and surrounding tissue; 2) parametric image of weights for blood were created using SVCA; 3) mask images to the individual PET image were inversely normalized; 4) carotid and surrounding tissue time activity curves (TACs) were obtained from weighted and unweighted averages of each voxel activity in each mask, respectively; 5) partial volume effects and radiometabolites were corrected using individual arterial data at four points. Logan-distribution volume (V T/f P) values obtained by cluster-IDIF were similar to reference results obtained using arterial data, as well as those obtained using manual-IDIF; 39 of 51 subjects had a V T/f P error of <5%, and only one had error >10%. With automatic voxel selection, cluster-IDIF curves were less noisy than manual-IDIF and free of operator-related variability. Cluster-IDIF showed widespread decrease of about 20% [(11)C](R)-rolipram binding in the MDD group. Taken together, the results suggest that cluster-IDIF is a good alternative to full arterial input function for estimating Logan-V T/f P in [(11)C](R)-rolipram PET clinical scans. This technique enables fully automated extraction of IDIF and can be applied to other radiotracers with similar kinetics. Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [11C](R)-rolipram positron emission tomography (PET) scans. However, manual-IDIF is time consuming and subject to inter- and intra-operator variability. To overcome this limitation, we developed a fully automated technique for deriving IDIF with a supervised clustering algorithm (SVCA). To validate this technique, 25 healthy controls and 26 patients with moderate to severe major depressive disorder (MDD) underwent T1-weighted brain magnetic resonance imaging (MRI) and a 90-minute [11C](R)-rolipram PET scan. For each subject, metabolite-corrected input function was measured from the radial artery. SVCA templates were obtained from 10 additional healthy subjects who underwent the same MRI and PET procedures. Cluster-IDIF was obtained as follows: 1) template mask images were created for carotid and surrounding tissue; 2) parametric image of weights for blood were created using SVCA; 3) mask images to the individual PET image were inversely normalized; 4) carotid and surrounding tissue time activity curves (TACs) were obtained from weighted and unweighted averages of each voxel activity in each mask, respectively; 5) partial volume effects and radiometabolites were corrected using individual arterial data at four points. Logan-distribution volume (VT/fP) values obtained by cluster-IDIF were similar to reference results obtained using arterial data, as well as those obtained using manual-IDIF; 39 of 51 subjects had a VT/fP error of <5%, and only one had error >10%. With automatic voxel selection, cluster-IDIF curves were less noisy than manual-IDIF and free of operator-related variability. Cluster-IDIF showed widespread decrease of about 20% [11C](R)-rolipram binding in the MDD group. Taken together, the results suggest that cluster-IDIF is a good alternative to full arterial input function for estimating Logan-VT/fP in [11C](R)-rolipram PET clinical scans. This technique enables fully automated extraction of IDIF and can be applied to other radiotracers with similar kinetics. Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [11C](R)-rolipram positron emission tomography (PET) scans. However, manual-IDIF is time consuming and subject to inter- and intra-operator variability. To overcome this limitation, we developed a fully automated technique for deriving IDIF with a supervised clustering algorithm (SVCA). To validate this technique, 25 healthy controls and 26 patients with moderate to severe major depressive disorder (MDD) underwent T1-weighted brain magnetic resonance imaging (MRI) and a 90-minute [11C](R)-rolipram PET scan. For each subject, metabolite-corrected input function was measured from the radial artery. SVCA templates were obtained from 10 additional healthy subjects who underwent the same MRI and PET procedures. Cluster-IDIF was obtained as follows: 1) template mask images were created for carotid and surrounding tissue; 2) parametric image of weights for blood were created using SVCA; 3) mask images to the individual PET image were inversely normalized; 4) carotid and surrounding tissue time activity curves (TACs) were obtained from weighted and unweighted averages of each voxel activity in each mask, respectively; 5) partial volume effects and radiometabolites were corrected using individual arterial data at four points. Logan-distribution volume (V T/f P) values obtained by cluster-IDIF were similar to reference results obtained using arterial data, as well as those obtained using manual-IDIF; 39 of 51 subjects had a V T/f P error of <5%, and only one had error >10%. With automatic voxel selection, cluster-IDIF curves were less noisy than manual-IDIF and free of operator-related variability. Cluster-IDIF showed widespread decrease of about 20% [11C](R)-rolipram binding in the MDD group. Taken together, the results suggest that cluster-IDIF is a good alternative to full arterial input function for estimating Logan-V T/f P in [11C](R)-rolipram PET clinical scans. This technique enables fully automated extraction of IDIF and can be applied to other radiotracers with similar kinetics. |
| Audience | Academic |
| Author | Zoghbi, Sami S. Fujita, Masahiro Liow, Jeih-San Xu, Rong Innis, Robert B. Lyoo, Chul Hyoung Pike, Victor W. Zarate, Carlos A. Zanotti-Fregonara, Paolo |
| AuthorAffiliation | 4 Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America 3 University of Bordeaux, CNRS, INCIA, UMR 5287, Talence, France University of Manchester, United Kingdom 2 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America 1 Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea |
| AuthorAffiliation_xml | – name: 2 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America – name: University of Manchester, United Kingdom – name: 4 Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America – name: 3 University of Bordeaux, CNRS, INCIA, UMR 5287, Talence, France – name: 1 Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea |
| Author_xml | – sequence: 1 givenname: Chul Hyoung surname: Lyoo fullname: Lyoo, Chul Hyoung – sequence: 2 givenname: Paolo surname: Zanotti-Fregonara fullname: Zanotti-Fregonara, Paolo – sequence: 3 givenname: Sami S. surname: Zoghbi fullname: Zoghbi, Sami S. – sequence: 4 givenname: Jeih-San surname: Liow fullname: Liow, Jeih-San – sequence: 5 givenname: Rong surname: Xu fullname: Xu, Rong – sequence: 6 givenname: Victor W. surname: Pike fullname: Pike, Victor W. – sequence: 7 givenname: Carlos A. surname: Zarate fullname: Zarate, Carlos A. – sequence: 8 givenname: Masahiro surname: Fujita fullname: Fujita, Masahiro – sequence: 9 givenname: Robert B. surname: Innis fullname: Innis, Robert B. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24586526$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kt1u0zAcxSM0xD7gDRBE4gYuWvyR2M4uJlWFsUpDoMG4QchyHCd15djBTirtRXhe3DadVgQokh0dn_8vJ8k5TY6ssypJnkMwhZjCtys3eCvMtIvyFABWQAAfJSewwGhCEMBHD-6Pk9MQVgDkmBHyJDlGWc5IjshJ8mvRikZN3imv16pKF7Yb-vRysLLXzqZ7ufauTUX6ZeiUX-sQlbkZQh9PbZPOTOO87pftefpR9UtXOeOau1TYKv0mjK7EFqVtBMyNtloKk372rnfSmfQ2bBDfIZz_eH3zZnLjjO68aJ8mj2thgno27mfJ7eX7r_OryfWnD4v57HoicwL6uCKBM1rFTRWFLAEUuahYKbOMUCRLQhCKC5QsozkQisZ3lhkQrMyorHCNz5KXO25nXODjJw0c5gDQHFKComOxc1ROrHjndSv8HXdC863gfMOF77U0iqsyByXGSqCaZgDVBcEFqpkEDAqmWB5ZF-PThrJVlVS298IcQA9PrF7yxq05LjAgjEXAqxHg3c9Bhf4fkUdXI2IqbWsXYbLVQfJZRhktaME2rulfXPGqVKtlLFWto34w8OJh-vvY-zJFw_nOIL0LwauaS91v_34ka8Mh4Jvm7jPzTXP52Nw4nP0xvOf_d-w3Nzz1cQ |
| CitedBy_id | crossref_primary_10_1016_j_nicl_2019_101681 crossref_primary_10_1177_0271678X18776820 crossref_primary_10_3389_fphy_2018_00047 crossref_primary_10_1186_s13550_023_01050_w crossref_primary_10_1016_j_cpet_2015_09_003 crossref_primary_10_1007_s40336_014_0069_8 crossref_primary_10_1186_s40658_016_0139_2 crossref_primary_10_1016_j_cmpb_2024_108375 crossref_primary_10_1186_s13550_024_01100_x crossref_primary_10_1097_MNM_0000000000000231 crossref_primary_10_1097_MNM_0000000000000184 crossref_primary_10_1088_2057_1976_ad6a64 crossref_primary_10_1186_s40658_023_00535_w |
| Cites_doi | 10.1109/NSSMIC.2009.5401977 10.1006/nimg.2001.0978 10.1038/jcbfm.2011.107 10.2165/00003088-198917040-00005 10.1016/j.neuroimage.2005.03.017 10.1088/0031-9155/52/23/019 10.1016/j.neuroimage.2003.09.058 10.1016/j.neuroimage.2012.08.007 10.1371/journal.pone.0017056 10.1109/TMI.2007.905106 10.2967/jnumed.112.105346 10.1016/S0893-133X(98)00107-9 10.1038/jcbfm.2013.43 10.1016/j.neuroimage.2010.10.064 10.1016/j.cmpb.2013.04.010 10.1097/00004728-199711000-00012 10.1109/IEMBS.2006.259416 10.1016/j.biopsych.2012.04.030 10.1038/npp.2012.255 10.1088/0031-9155/47/3/307 10.1007/s00259-010-1443-z 10.1016/j.neurobiolaging.2012.04.021 10.1109/TNS.2002.998752 10.1038/jcbfm.2009.93 10.1007/s10334-012-0347-2 10.1097/MNM.0b013e328356185c 10.1038/jcbfm.2012.59 10.1016/S0895-6111(99)00017-8 10.1097/00004647-199807000-00002 10.1212/01.wnl.0000338622.27876.0d |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2014 Public Library of Science 2014. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 |
| Copyright_xml | – notice: COPYRIGHT 2014 Public Library of Science – notice: 2014. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 5PM DOA |
| DOI | 10.1371/journal.pone.0089101 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & environmental science database online journals ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database (Proquest) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) |
| DatabaseTitleList | MEDLINE Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine Biology Mathematics Computer Science |
| DocumentTitleAlternate | IDIF from Clustering Algorithm |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1500751762 oai_doaj_org_article_eb50b33ea2f7402f96392f8c081a8e85 PMC3930688 3225016301 A478797982 24586526 10_1371_journal_pone_0089101 |
| Genre | Validation Studies Journal Article Research Support, N.I.H., Intramural |
| GeographicLocations | United States--US Maryland |
| GeographicLocations_xml | – name: Maryland – name: United States--US |
| GrantInformation_xml | – fundername: Intramural NIH HHS |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM PV9 RIG RZL 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c560t-c52a347d52ae99cb01a5ad8bc44672cb6622b661c84750ae7526c40a8b47cd3f3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 16 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000331714700060&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Thu Nov 25 14:37:23 EST 2021 Fri Oct 03 12:21:25 EDT 2025 Tue Nov 04 01:52:42 EST 2025 Tue Oct 07 07:11:08 EDT 2025 Sat Nov 29 13:13:50 EST 2025 Sat Nov 29 10:13:47 EST 2025 Thu Apr 03 07:06:14 EDT 2025 Tue Nov 18 21:45:38 EST 2025 Sat Nov 29 02:39:22 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Creative Commons CC0 public domain |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c560t-c52a347d52ae99cb01a5ad8bc44672cb6622b661c84750ae7526c40a8b47cd3f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: CHL PZF RBI. Performed the experiments: CHL PZF SSZ JSL RX MF. Analyzed the data: CHL PZF MF. Contributed reagents/materials/analysis tools: CHL PZF SSZ JSL RX VWP MF RBI. Wrote the paper: CHL PZF SSZ JSL RX VWP CAZ MF RBI. |
| OpenAccessLink | https://doaj.org/article/eb50b33ea2f7402f96392f8c081a8e85 |
| PMID | 24586526 |
| PQID | 1500751762 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1500751762 doaj_primary_oai_doaj_org_article_eb50b33ea2f7402f96392f8c081a8e85 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3930688 proquest_journals_1500751762 gale_infotracmisc_A478797982 gale_infotracacademiconefile_A478797982 pubmed_primary_24586526 crossref_citationtrail_10_1371_journal_pone_0089101 crossref_primary_10_1371_journal_pone_0089101 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-02-20 |
| PublicationDateYYYYMMDD | 2014-02-20 |
| PublicationDate_xml | – month: 02 year: 2014 text: 2014-02-20 day: 20 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2014 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | K Chen (ref20) 1998; 18 P Zanotti-Fregonara (ref4) 2012; 63 P Zanotti-Fregonara (ref2) 2011; 54 P Zanotti-Fregonara (ref26) 2011; 31 P Edison (ref31) 2013; 38 KP Wong (ref7) 2002; 49 A Juslin (ref11) 2006; 1 M Fujita (ref1) 2012; 72 R Maroy (ref9) 2008; 27 FE Turkheimer (ref12) 2007; 48 C Catana (ref28) 2012; 53 JM Mateos-Perez (ref13) 2013; 111 P Zanotti-Fregonara (ref21) 2012; 33 N Tzourio-Mazoyer (ref18) 2002; 15 K Chen (ref23) 2007; 52 P Zanotti-Fregonara (ref33) 2009; 29 SS Zoghbi (ref15) 2006; 47 Y Kimura (ref10) 2002; 47 M Fujita (ref14) 2005; 26 AO Boudraa (ref5) 1999; 23 M Liptrot (ref8) 2004; 21 Y Sawada (ref16) 1990; 27 A Okello (ref32) 2009; 72 E Croteau (ref25) 2010; 37 ref27 B Sattler (ref29) 2013; 26 A Schuitemaker (ref30) 2013; 34 WL Chiou (ref34) 1989; 17 ref3 ref6 JE Litton (ref24) 1997; 21 M Yaqub (ref19) 2012; 32 A Abi-Dargham (ref17) 1999; 20 P Zanotti-Fregonara (ref22) 2011; 6 10327433 - Neuropsychopharmacology. 1999 Jun;20(6):650-61 23143086 - J Nucl Med. 2012 Dec;53(12):1916-25 21034834 - Neuroimage. 2011 Feb 1;54(3):1903-9 18029993 - Phys Med Biol. 2007 Dec 7;52(23):7055-71 2686884 - Clin Pharmacokinet. 1989 Oct;17(4):275-90 22760300 - Nucl Med Commun. 2012 Sep;33(9):982-9 22677471 - Biol Psychiatry. 2012 Oct 1;72(7):548-54 22906792 - Neuroimage. 2012 Nov 15;63(3):1532-41 17204713 - J Nucl Med. 2007 Jan;48(1):158-67 15961054 - Neuroimage. 2005 Jul 15;26(4):1201-10 20437239 - Eur J Nucl Med Mol Imaging. 2010 Aug;37(8):1539-50 21811289 - J Cereb Blood Flow Metab. 2011 Oct;31(10):1986-98 17946020 - Conf Proc IEEE Eng Med Biol Soc. 2006;1:1077-80 9386282 - J Comput Assist Tomogr. 1997 Nov-Dec;21(6):907-9 10551724 - Comput Med Imaging Graph. 1999 Jul-Aug;23(4):181-91 18334430 - IEEE Trans Med Imaging. 2008 Mar;27(3):342-54 19584890 - J Cereb Blood Flow Metab. 2009 Nov;29(11):1825-35 23512132 - J Cereb Blood Flow Metab. 2013 Jul;33(7):1032-40 20607124 - IEEE Nucl Sci Symp Conf Rec (1997). 2009 Oct 24;2009:2710-2714 2186640 - Am J Physiol. 1990 May;258(5 Pt 2):H1585-98 22840559 - Neurobiol Aging. 2013 Jan;34(1):128-36 16513622 - J Nucl Med. 2006 Mar;47(3):520-7 9663501 - J Cereb Blood Flow Metab. 1998 Jul;18(7):716-23 22588187 - J Cereb Blood Flow Metab. 2012 Aug;32(8):1600-8 23693137 - Comput Methods Programs Biomed. 2013 Aug;111(2):308-14 23053713 - MAGMA. 2013 Feb;26(1):159-71 23303049 - Neuropsychopharmacology. 2013 May;38(6):938-49 14980551 - Neuroimage. 2004 Feb;21(2):483-93 11771995 - Neuroimage. 2002 Jan;15(1):273-89 19122031 - Neurology. 2009 Jan 6;72(1):56-62 21364880 - PLoS One. 2011;6(2):e17056 11848122 - Phys Med Biol. 2002 Feb 7;47(3):455-68 |
| References_xml | – ident: ref27 doi: 10.1109/NSSMIC.2009.5401977 – volume: 15 start-page: 273 year: 2002 ident: ref18 article-title: Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain publication-title: Neuroimage doi: 10.1006/nimg.2001.0978 – volume: 31 start-page: 1986 year: 2011 ident: ref26 article-title: Image-derived input function for brain PET studies: many challenges and few opportunities publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2011.107 – volume: 17 start-page: 275 year: 1989 ident: ref34 article-title: The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part II) publication-title: Clin Pharmacokinet doi: 10.2165/00003088-198917040-00005 – volume: 48 start-page: 158 year: 2007 ident: ref12 article-title: Reference and target region modeling of [11C]-(R)-PK11195 brain studies publication-title: J Nucl Med – volume: 26 start-page: 1201 year: 2005 ident: ref14 article-title: Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]rolipram-PET publication-title: NeuroImage doi: 10.1016/j.neuroimage.2005.03.017 – volume: 47 start-page: 520 year: 2006 ident: ref15 article-title: PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements publication-title: J Nucl Med – volume: 52 start-page: 7055 year: 2007 ident: ref23 article-title: Characterization of the image-derived carotid artery input function using independent component analysis for the quantitation of [18F] fluorodeoxyglucose positron emission tomography images publication-title: Phys Med Biol doi: 10.1088/0031-9155/52/23/019 – volume: 21 start-page: 483 year: 2004 ident: ref8 article-title: Cluster analysis in kinetic modelling of the brain: a noninvasive alternative to arterial sampling publication-title: Neuroimage doi: 10.1016/j.neuroimage.2003.09.058 – volume: 63 start-page: 1532 year: 2012 ident: ref4 article-title: Population-based input function and image-derived input function for [11C](R)-rolipram PET imaging: Methodology, validation and application to the study of major depressive disorder publication-title: Neuroimage doi: 10.1016/j.neuroimage.2012.08.007 – volume: 6 start-page: e17056 year: 2011 ident: ref22 article-title: Image-Derived Input Function for Human Brain Using High Resolution PET Imaging with [C](R)-rolipram and [C]PBR28 publication-title: Plos One doi: 10.1371/journal.pone.0017056 – volume: 27 start-page: 342 year: 2008 ident: ref9 article-title: Segmentation of rodent whole-body dynamic PET images: an unsupervised method based on voxel dynamics publication-title: IEEE Trans Med Imaging doi: 10.1109/TMI.2007.905106 – volume: 53 start-page: 1916 year: 2012 ident: ref28 article-title: PET/MRI for neurologic applications publication-title: J Nucl Med doi: 10.2967/jnumed.112.105346 – volume: 20 start-page: 650 year: 1999 ident: ref17 article-title: No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(98)00107-9 – ident: ref3 doi: 10.1038/jcbfm.2013.43 – volume: 54 start-page: 1903 year: 2011 ident: ref2 article-title: Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.10.064 – volume: 111 start-page: 308 year: 2013 ident: ref13 article-title: Automatic TAC extraction from dynamic cardiac PET imaging using iterative correlation from a population template publication-title: Comput Methods Programs Biomed doi: 10.1016/j.cmpb.2013.04.010 – volume: 21 start-page: 907 year: 1997 ident: ref24 article-title: Input function in PET brain studies using MR-defined arteries publication-title: J Comput Assist Tomogr doi: 10.1097/00004728-199711000-00012 – volume: 27) start-page: H1585 year: 1990 ident: ref16 article-title: Cerebrovascular transport of [125I]quinuclidinyl benzilate, [3H]cyclofoxy, and [14C]iodoantipyrine. Am J Physiol 258 (Heart Circ. Physiol – ident: ref6 – volume: 1 start-page: 1077 year: 2006 ident: ref11 article-title: Unsupervised segmentation of cardiac PET transmission images for automatic heart volume extraction publication-title: Conf Proc IEEE Eng Med Biol Soc doi: 10.1109/IEMBS.2006.259416 – volume: 72 start-page: 548 year: 2012 ident: ref1 article-title: Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2012.04.030 – volume: 38 start-page: 938 year: 2013 ident: ref31 article-title: Microglia, amyloid, and glucose metabolism in Parkinson’s disease with and without dementia publication-title: Neuropsychopharmacology doi: 10.1038/npp.2012.255 – volume: 47 start-page: 455 year: 2002 ident: ref10 article-title: Fast formation of statistically reliable FDG parametric images based on clustering and principal components publication-title: Physics in Medicine and Biology doi: 10.1088/0031-9155/47/3/307 – volume: 37 start-page: 1539 year: 2010 ident: ref25 article-title: Image-derived input function in dynamic human PET/CT: methodology and validation with (11)C-acetate and (18)F-fluorothioheptadecanoic acid in muscle and (18)F-fluorodeoxyglucose in brain publication-title: Eur J Nucl Med Mol Imaging doi: 10.1007/s00259-010-1443-z – volume: 34 start-page: 128 year: 2013 ident: ref30 article-title: Microglial activation in Alzheimer’s disease: an (R)-[(1)(1)C]PK11195 positron emission tomography study publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2012.04.021 – volume: 49 start-page: 200 year: 2002 ident: ref7 article-title: Segmentation of dynamic PET images using cluster analysis publication-title: IEEE TRANSACTIONS ON NUCLEAR SCIENCE doi: 10.1109/TNS.2002.998752 – volume: 29 start-page: 1825 year: 2009 ident: ref33 article-title: Comparison of eight methods for the estimation of the image-derived input function in dynamic [(18)F]-FDG PET human brain studies publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2009.93 – volume: 26 start-page: 159 year: 2013 ident: ref29 article-title: Physical and organizational provision for installation, regulatory requirements and implementation of a simultaneous hybrid PET/MR-imaging system in an integrated research and clinical setting publication-title: MAGMA doi: 10.1007/s10334-012-0347-2 – volume: 33 start-page: 982 year: 2012 ident: ref21 article-title: Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifacts publication-title: Nucl Med Commun doi: 10.1097/MNM.0b013e328356185c – volume: 32 start-page: 1600 year: 2012 ident: ref19 article-title: Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2012.59 – volume: 23 start-page: 181 year: 1999 ident: ref5 article-title: Analysis of dynamic nuclear cardiac images by covariance function publication-title: Computerized Medical Imaging and Graphics doi: 10.1016/S0895-6111(99)00017-8 – volume: 18 start-page: 716 year: 1998 ident: ref20 article-title: Noninvasive quantification of the cerebral metabolic rate for glucose using positron emission tomography, 18F-fluoro-2-deoxyglucose, the Patlak method, and an image-derived input function publication-title: J Cereb Blood Flow Metab doi: 10.1097/00004647-199807000-00002 – volume: 72 start-page: 56 year: 2009 ident: ref32 article-title: Microglial activation and amyloid deposition in mild cognitive impairment: a PET study publication-title: Neurology doi: 10.1212/01.wnl.0000338622.27876.0d – reference: 22840559 - Neurobiol Aging. 2013 Jan;34(1):128-36 – reference: 10327433 - Neuropsychopharmacology. 1999 Jun;20(6):650-61 – reference: 11771995 - Neuroimage. 2002 Jan;15(1):273-89 – reference: 17946020 - Conf Proc IEEE Eng Med Biol Soc. 2006;1:1077-80 – reference: 14980551 - Neuroimage. 2004 Feb;21(2):483-93 – reference: 9663501 - J Cereb Blood Flow Metab. 1998 Jul;18(7):716-23 – reference: 20437239 - Eur J Nucl Med Mol Imaging. 2010 Aug;37(8):1539-50 – reference: 2686884 - Clin Pharmacokinet. 1989 Oct;17(4):275-90 – reference: 21034834 - Neuroimage. 2011 Feb 1;54(3):1903-9 – reference: 23053713 - MAGMA. 2013 Feb;26(1):159-71 – reference: 22760300 - Nucl Med Commun. 2012 Sep;33(9):982-9 – reference: 20607124 - IEEE Nucl Sci Symp Conf Rec (1997). 2009 Oct 24;2009:2710-2714 – reference: 22677471 - Biol Psychiatry. 2012 Oct 1;72(7):548-54 – reference: 16513622 - J Nucl Med. 2006 Mar;47(3):520-7 – reference: 23303049 - Neuropsychopharmacology. 2013 May;38(6):938-49 – reference: 21811289 - J Cereb Blood Flow Metab. 2011 Oct;31(10):1986-98 – reference: 10551724 - Comput Med Imaging Graph. 1999 Jul-Aug;23(4):181-91 – reference: 23143086 - J Nucl Med. 2012 Dec;53(12):1916-25 – reference: 23512132 - J Cereb Blood Flow Metab. 2013 Jul;33(7):1032-40 – reference: 17204713 - J Nucl Med. 2007 Jan;48(1):158-67 – reference: 22906792 - Neuroimage. 2012 Nov 15;63(3):1532-41 – reference: 18029993 - Phys Med Biol. 2007 Dec 7;52(23):7055-71 – reference: 11848122 - Phys Med Biol. 2002 Feb 7;47(3):455-68 – reference: 22588187 - J Cereb Blood Flow Metab. 2012 Aug;32(8):1600-8 – reference: 19584890 - J Cereb Blood Flow Metab. 2009 Nov;29(11):1825-35 – reference: 15961054 - Neuroimage. 2005 Jul 15;26(4):1201-10 – reference: 9386282 - J Comput Assist Tomogr. 1997 Nov-Dec;21(6):907-9 – reference: 19122031 - Neurology. 2009 Jan 6;72(1):56-62 – reference: 2186640 - Am J Physiol. 1990 May;258(5 Pt 2):H1585-98 – reference: 18334430 - IEEE Trans Med Imaging. 2008 Mar;27(3):342-54 – reference: 23693137 - Comput Methods Programs Biomed. 2013 Aug;111(2):308-14 – reference: 21364880 - PLoS One. 2011;6(2):e17056 |
| SSID | ssj0053866 |
| Score | 2.2050831 |
| Snippet | Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [(11)C](R)-rolipram positron emission... Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [.sup.11 C](R)-rolipram positron... Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [11C](R)-rolipram positron emission... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e89101 |
| SubjectTerms | Adult Algorithms Arteries Automation Biology Brain Brain research Carbon Radioisotopes Carotid arteries Carotid Arteries - diagnostic imaging Carotid Arteries - physiopathology Carotid artery Case-Control Studies Cluster Analysis Clustering Clusters Computer Science Depressive Disorder, Major - blood Depressive Disorder, Major - diagnostic imaging Depressive Disorder, Major - metabolism Depressive Disorder, Major - physiopathology Female Humans Image processing Image Processing, Computer-Assisted - methods Kinetics Magnetic resonance Magnetic resonance imaging Male Mathematics Medical imaging Medicine Mental depression Mental health Metabolites Methods Neuroimaging Plasma Positron emission Positron emission tomography Radioactive tracers Rolipram Rolipram - metabolism Studies Tomography Variability Veins & arteries |
| SummonAdditionalLinks | – databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9MwGLagcOACjI8tMJAPSGyHsCRObIcLKoWKHZimAtMkhCLHsbdKaRKSdD-F38tr1ykETXDgkki2E9vx837YsZ8XoRdcg8xopfxE89SPo0L7nITUjxWYe63TRCW5DTbBTk74-Xl66hbcOretctCJVlEXtTRr5EfguIB1C0F23zTffRM1yvxddSE0bqJbofGNAc9scTZoYpBlSt1xOcLCIzc6r5q6UobWFCxlODJHlrV_q5snTVl31zmef-6f_M0gze_9b1fuo7vOFcXTDXZ20A1VPUA7Ttg7fOAYqQ8foh_HK1A7_jtA65Uq8HHVrHs8B4toRhUPyeakChb407ox-qeDlFm5NjwMYB3xtLyAJvSXq9f4ow1abZfzsagKfAZTgU1kJ7ys4AWOqrTEp23d1wBUbPc14K9hOPt2sDj0F3W5bFqxeoS-zN9_nn3wXUAHX4Jj1cM1EiRmBdxUmso8CEUiCp5LmJOySOaURhFcQgkmMwmEYklEZRwInsdMFkSTx2hSweDtIayppuB50bzIeayYEDQQRUwIK0gsciY8RIZxzaRjOzdBN8rM_sJjMOvZfOXMoCFzaPCQv32q2bB9_KP8WwOZbVnD1W0T6vYic6KfqTwJckKUiDSD2boGlZdGmktwxgRXPPHQSwO4zGgUaKIU7mAE1GO4ubKp4U9KWcojD-2PSoImkKPsPQPZoaVd9gto8OQAxeuzdzeI3vYkihNO4fN7iI2wPurqOKdaXlp6cpISE8noyd-rfIrugO8ZW3aAYB9N-natnqHb8qpfdu1zK8c_AXMGVZM priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFLZQ4YEXYNwWGMgPSGwPgcRObIe3UqiYBFM1LpqEUOQ4NouUJlGS7qfwezlO3EKmTYiXVPKldY6_c2vi7yD0QhjQGaO1HxuR-BHJjS9oyPxIg7s3Jol1nA3FJvjJiTg7S1Z_EsVLT_ApD187mb5q6kpbMlLwb5Dt3CSUMZtsLVcft5YXdJcxdzzuupkT9zOw9O9s8awp6-6qQPPy-5J_OaDl3f9d-j10x4WaeD5iYw_d0NV9tOeUucOHjnH66AH6dbwGs-K_AzRe6BwfV82mx0vweHbX8LbZnkTBEn_eNNa-dNCyKDeWZwG8H56XP-u26M_Xb_CnoSj18Hc9llWOv0GoP1ZuwkUFX-CoSEu8auu-BiDi4b0F_D0MFz8OT4_807osmlauH6Kvy_dfFh98V7DBVxA49XAlkkY8hw-dJCoLQhnLXGQKck5OVMYYIXAJFbjEOJCax4SpKJAii7jKqaGP0KwCWe0jbJhhEFmxLM9EpLmULJB5RCnPaSQzLj1Et_uYKsdmbotqlOnwiI5DVjNKObXCT53wPeTvZjUjm8c_xr-1ENmNtVzcQwPscupUO9VZHGSUakkMh2zcgElLiBEKgi0ptIg99NICLLUWA5aopDv4AL9jubfSueVHSngiiIcOJiNB09Wke99CdLvSLoVgHiK-EPwZzNzC9uruxyOCd3dColgwEL-H-ATbk1ud9lTF-UA_ThNqKxU9uX41T9FtiCuj4eR_cIBmfbvRz9AtddEXXft80NnfngtDyA priority: 102 providerName: Public Library of Science |
| Title | Image-Derived Input Function Derived from a Supervised Clustering Algorithm: Methodology and Validation in a Clinical Protocol Using [11C](R)-Rolipram |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24586526 https://www.proquest.com/docview/1500751762 https://pubmed.ncbi.nlm.nih.gov/PMC3930688 https://doaj.org/article/eb50b33ea2f7402f96392f8c081a8e85 http://dx.doi.org/10.1371/journal.pone.0089101 |
| Volume | 9 |
| WOSCitedRecordID | wos000331714700060&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest advanced technologies & aerospace journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bb9MwFLag8MALYtxWGJUfkNgesiVxYju8rdUqprEqKhcVEIocx94qtWnUtPsp_F7OyaVa0KS98HIq-ZI6Pp99jluf7xDyXlpYM9YYJ7QycgI_s45kHncCA-be2ig0YVolmxCTiZzNovhWqi-8E1bTA9cTd2LS0E0ZM8q3As46FgAT-VZqMGVKGlmxl7oiag9T9R4Mq5jzJlCOCe-k0ctxscoNEpqCjfQ6hqji69_tyr1isSrvcjn_vTl5yxSNn5GnjQ9JT-ux75EHJn9O9ppVWtLDhkr66AX5c76E_cLJAGY3JqPzvNhuKJoyVAdtizHEhCpabgvcOEoo0YstEiiAWaNqcbVazzfXy4-0zjZd_Q5PVZ5RAOm8TskET4YHtFGWFMkfVoAwirfqr-gvzxv9PpweOZghqFir5UvybXz2dfTJaTIxOBo8og1IX7FAZPBhokinrqdClclUw2FS-Drl3PdBeBpsXegqI0Kf68BVMg2Ezphlr0gvh7nfJ9Ryy8Fl4mmWysAIpbirsoAxkbFApUL1CWvVkuiGphyzZSyS6r83AceVepYTVGbSKLNPnF2voqbpuKf9EDW-a4sk21UBQC9poJfcB70--YB4SXArgCFq1UQ0wPcgqVZyisRHkYik3ycHnZawhHWneh8R1460TMBLB1fOA0MFPVsU3l39ugbk7k38IJQcpr9PRAeqnVft1uTz64pXnEUMUxC9-R9z85Y8AdcyqIL_3QPS26y35h15rG8283I9IA_F9DvKmQApR96APBqeTeLpoFrGIMfxZ5AXw2OQl-4FShFX8gvIOPwJPeLzy_jHXwlaVJE |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLZGQYIXYNxWGOAHENtDWGI7cYKEUOmoVm2rpjHQBELBceytUpqEJh3ij_Az-I0c51IImuBpD7ykUuxc7H7nO8ex_R2EnvgabEYrZbnaDyxGYm351PEspsDdax24yo2qZBN8MvGPj4ODFfSj3QtjllW2nFgRdZxJ8418CwIX8G4O2O6r_ItlskaZ2dU2hUYNi1317SsM2YqX4234f58SMnpzNNyxmqwClgTvXsKRCMp4DD8qCGRkO8IVsR9JGBhxIiPPIwQOjgTedm2huEs8yWzhR4zLmGoK972ELjNGbGNFB-6HlvmBOzyv2Z5HubPVoOF5nqXKyKiCZ3Y67q_KErD0Bb08yYrzAt0_12v-5gBHN_63rruJrjehNh7UtrGKVlR6C602ZFbgjUZxe_M2-j6eAa1a22CNZyrG4zRflHgEHt-gFrenzU4cLPDbRW74tYAzw2RhdCbA--NBcgJNLk9nL_B-lZS7mq7AIo3xexjq1Jmr8DSFGzRSrAk-mGdlBoaIq3Ub-KPjDD9tHG5ah1kyzedidge9u5D-uYt6KYBlDWHtaQ8iSy-KI58pLoRni5hRymPKRMRFH9EWR6Fs1NxNUpEkrKYoOYzq6l4ODfrCBn19ZC2vyms1k3_Uf20guqxrtMirE9n8JGyoLVSRa0eUKkE0ZzbRQOkB0b6EYFP4ynf76JkBeGgYE15RimbjBzzHaI-FA6MPFfDAJ3203qkJTCc7xWvGRNo3LcJfwIYrW-ifX3yvtqBlSwhzfQ-6v494x7Y6Te2WpNPTSn6dBtRkarr_90c-Rld3jvb3wr3xZPcBugZxNquUEOx11CvnC_UQXZFn5bSYP6o4BKPPF215PwG3zLH8 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLZGQYgXYNxWGOAHENtDaGInsYOEUGmpqAZTNS6aQCg4jr1VSpPQpEP8EX4Mv47jXApBEzztgZdUip2L3fN95zi2v4PQA64BM1opy9M8sFwSa4tTx7dcBe5e68BTXlQlm2D7-_zwMJhtoB_tXhizrLLlxIqo40yab-QDCFzAuzmA3YFulkXMxpNn-RfLZJAyM61tOo3aRPbUt68wfCueTsfwXz8kZPLi7eil1WQYsCR4-hKORFCXxfCjgkBGtiM8EfNIwiCJERn5PiFwcCRwuGcLxTziS9cWPHKZjKmmcN9z6DyDMaZZTjjzPrReAHjE95utepQ5g8YyHudZqoykKnhpp-MKq4wBa7_Qy5OsOC3o_XPt5m_OcHLlf-7Gq-hyE4LjYY2ZTbSh0mtosyG5Au80Sty719H36QLo1hoDSk9UjKdpvirxBCIBY824PW126GCB36xyw7sFnBklK6M_AVEBHiZH0OTyePEEv66SdVfTGFikMX4PQ6A6oxWep3CDRqI1wbNlVmYAUFyt58AfHWf0aedg1zrIknm-FIsb6N2Z9M9N1EvBcLYQ1r72IeL0ozjirmJC-LaIXUpZTF0RMdFHtLWpUDYq7ybZSBJWU5cMRnt1L4fGEsPGEvvIWl-V1yon_6j_3Jjruq7RKK9OZMujsKG8UEWeHVGqBNHMtYkGqg-I5hKCUMEV9_rokTH20DApvKIUzYYQeI7RJAuHRjcqYAEnfbTdqQkMKDvFWwYu7ZsW4S8jhytbGJxefKtG07olxPW4D93fR6yDs05TuyXp_LiSZacBNRmcbv_9kffRRQBc-Gq6v3cHXYLw260EEuxt1CuXK3UXXZAn5bxY3qvoBKPPZw28n1epusY |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Image-derived+input+function+derived+from+a+supervised+clustering+algorithm%3A+methodology+and+validation+in+a+clinical+protocol+using+%5B11C%5D%28R%29-rolipram&rft.jtitle=PloS+one&rft.au=Chul+Hyoung+Lyoo&rft.au=Paolo+Zanotti-Fregonara&rft.au=Sami+S+Zoghbi&rft.au=Jeih-San+Liow&rft.date=2014-02-20&rft.pub=Public+Library+of+Science+%28PLoS%29&rft.eissn=1932-6203&rft.volume=9&rft.issue=2&rft.spage=e89101&rft_id=info:doi/10.1371%2Fjournal.pone.0089101&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_eb50b33ea2f7402f96392f8c081a8e85 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |