Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of...

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Vydáno v:Lancet neurology Ročník 17; číslo 2; s. 162 - 173
Hlavní autoři: Thompson, Alan J, Banwell, Brenda L, Barkhof, Frederik, Carroll, William M, Coetzee, Timothy, Comi, Giancarlo, Correale, Jorge, Fazekas, Franz, Filippi, Massimo, Freedman, Mark S, Fujihara, Kazuo, Galetta, Steven L, Hartung, Hans Peter, Kappos, Ludwig, Lublin, Fred D, Marrie, Ruth Ann, Miller, Aaron E, Miller, David H, Montalban, Xavier, Mowry, Ellen M, Sorensen, Per Soelberg, Tintoré, Mar, Traboulsee, Anthony L, Trojano, Maria, Uitdehaag, Bernard M J, Vukusic, Sandra, Waubant, Emmanuelle, Weinshenker, Brian G, Reingold, Stephen C, Cohen, Jeffrey A
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.02.2018
Elsevier Limited
Témata:
Adult
Aged
Brain research
Central nervous system
Cerebral Cortex - pathology
Cerebrospinal fluid
Cortex
Demyelinating Diseases - diagnosis
Diagnosis
Diagnostic tests
Humans
Laboratories
Magnetic Resonance Imaging
Medical diagnosis
Meetings
Middle Aged
Multiple sclerosis
Multiple Sclerosis - diagnosis
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
Neurologic Examination
Neurology
NMR
Nuclear magnetic resonance
Oligoclonal Bands - cerebrospinal fluid
Optic nerve
Regulatory approval
Revisions
Spinal cord
Spinal Cord - pathology
Systematic review
United States > US
ISSN:1474-4422, 1474-4465, 1474-4465
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Shrnutí:The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The following changes were made: in patients with a typical clinically isolated syndrome and clinical or MRI demonstration of dissemination in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple sclerosis; symptomatic lesions can be used to demonstrate dissemination in space or time in patients with supratentorial, infratentorial, or spinal cord syndrome; and cortical lesions can be used to demonstrate dissemination in space. Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers.
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ISSN:1474-4422
1474-4465
1474-4465
DOI:10.1016/S1474-4422(17)30470-2