Potential Benefits of Black Chokeberry (Aronia melanocarpa) Fruits and Their Constituents in Improving Human Health

Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human...

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Veröffentlicht in:Molecules (Basel, Switzerland) Jg. 27; H. 22; S. 7823
Hauptverfasser: Ren, Yulin, Frank, Tyler, Meyer, Gunnar, Lei, Jizhou, Grebenc, Jessica R., Slaughter, Ryan, Gao, Yu G., Kinghorn, A. Douglas
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 01.11.2022
MDPI
Schlagworte:
Amino acids
Anthocyanin
Anthocyanins - chemistry
anti-infectives
Antidiabetics
Antifungal agents
Antioxidants
Antioxidants - chemistry
antitumor effects
Aronia melanocarpa
Berries
black chokeberry
Cancer
Cell cycle
Cell growth
Chemotherapy
Chlorogenic Acid - analysis
Clinical trials
Colorectal cancer
COVID-19 Drug Treatment
Cyclin-dependent kinases
Cytotoxicity
Development and progression
Enzymes
Fruit
Fruit - chemistry
Health aspects
Humans
Kinases
Liver cancer
Lung cancer
Metastasis
Natural products
Oncology, Experimental
Oxidative stress
phenolic constituents
Photinia - chemistry
Quercetin - analysis
Review
Stem cells
United States
black chokeberry
Aronia melanocarpa
antioxidants
antitumor effects
anti-infectives
human health
phenolic constituents
ISSN:1420-3049, 1420-3049
Online-Zugang:Volltext
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Zusammenfassung:Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human health, including antidiabetic, anti-infective, antineoplastic, antiobesity, and antioxidant activities, as well as heart-, liver-, and neuroprotective effects. Thus far, phenolic compounds, such as anthocyanins, cyanidins, phenolic acids, proanthocyanidins, triterpenoids, and their analogues have been identified as the major active components of Aronia berries. These natural products possess potent antioxidant activity, which contributes to the majority of the other bioactivities observed for Aronia berries. The chemical components and the potential pharmaceutical or health-promoting effects of Aronia berries have been summarized previously. The present review article focuses on the molecular targets of extracts of Aronia berries and the examples of promising lead compounds isolated from these berries, including cyanidin-3-O-galactoside, chlorogenic acid, quercetin, and ursolic acid. In addition, presented herein are clinical trial investigations for Aronia berries and their major components, including cancer clinical trials for chlorogenic acid and COVID-19 trial studies for quercetin. Additionally, the possible development of Aronia berries and their secondary metabolites as potential therapeutic agents is discussed. It is hoped that this contribution will help stimulate future investigations on Aronia berries for the continual improvement of human health.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27227823