Potential Benefits of Black Chokeberry (Aronia melanocarpa) Fruits and Their Constituents in Improving Human Health

Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human...

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Vydané v:	Molecules (Basel, Switzerland) Ročník 27; číslo 22; s. 7823
Hlavní autori:	Ren, Yulin, Frank, Tyler, Meyer, Gunnar, Lei, Jizhou, Grebenc, Jessica R., Slaughter, Ryan, Gao, Yu G., Kinghorn, A. Douglas
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 01.11.2022 MDPI
Predmet:	Amino acids Anthocyanin Anthocyanins - chemistry anti-infectives Antidiabetics Antifungal agents Antioxidants Antioxidants - chemistry antitumor effects Aronia melanocarpa Berries black chokeberry Cancer Cell cycle Cell growth Chemotherapy Chlorogenic Acid - analysis Clinical trials Colorectal cancer COVID-19 Drug Treatment Cyclin-dependent kinases Cytotoxicity Development and progression Enzymes Fruit Fruit - chemistry Health aspects Humans Kinases Liver cancer Lung cancer Metastasis Natural products Oncology, Experimental Oxidative stress phenolic constituents Photinia - chemistry Quercetin - analysis Review Stem cells United States black chokeberry Aronia melanocarpa antioxidants antitumor effects anti-infectives human health phenolic constituents
ISSN:	1420-3049, 1420-3049
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Abstract	Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human health, including antidiabetic, anti-infective, antineoplastic, antiobesity, and antioxidant activities, as well as heart-, liver-, and neuroprotective effects. Thus far, phenolic compounds, such as anthocyanins, cyanidins, phenolic acids, proanthocyanidins, triterpenoids, and their analogues have been identified as the major active components of Aronia berries. These natural products possess potent antioxidant activity, which contributes to the majority of the other bioactivities observed for Aronia berries. The chemical components and the potential pharmaceutical or health-promoting effects of Aronia berries have been summarized previously. The present review article focuses on the molecular targets of extracts of Aronia berries and the examples of promising lead compounds isolated from these berries, including cyanidin-3-O-galactoside, chlorogenic acid, quercetin, and ursolic acid. In addition, presented herein are clinical trial investigations for Aronia berries and their major components, including cancer clinical trials for chlorogenic acid and COVID-19 trial studies for quercetin. Additionally, the possible development of Aronia berries and their secondary metabolites as potential therapeutic agents is discussed. It is hoped that this contribution will help stimulate future investigations on Aronia berries for the continual improvement of human health.
AbstractList	Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human health, including antidiabetic, anti-infective, antineoplastic, antiobesity, and antioxidant activities, as well as heart-, liver-, and neuroprotective effects. Thus far, phenolic compounds, such as anthocyanins, cyanidins, phenolic acids, proanthocyanidins, triterpenoids, and their analogues have been identified as the major active components of Aronia berries. These natural products possess potent antioxidant activity, which contributes to the majority of the other bioactivities observed for Aronia berries. The chemical components and the potential pharmaceutical or health-promoting effects of Aronia berries have been summarized previously. The present review article focuses on the molecular targets of extracts of Aronia berries and the examples of promising lead compounds isolated from these berries, including cyanidin-3-O-galactoside, chlorogenic acid, quercetin, and ursolic acid. In addition, presented herein are clinical trial investigations for Aronia berries and their major components, including cancer clinical trials for chlorogenic acid and COVID-19 trial studies for quercetin. Additionally, the possible development of Aronia berries and their secondary metabolites as potential therapeutic agents is discussed. It is hoped that this contribution will help stimulate future investigations on Aronia berries for the continual improvement of human health.Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human health, including antidiabetic, anti-infective, antineoplastic, antiobesity, and antioxidant activities, as well as heart-, liver-, and neuroprotective effects. Thus far, phenolic compounds, such as anthocyanins, cyanidins, phenolic acids, proanthocyanidins, triterpenoids, and their analogues have been identified as the major active components of Aronia berries. These natural products possess potent antioxidant activity, which contributes to the majority of the other bioactivities observed for Aronia berries. The chemical components and the potential pharmaceutical or health-promoting effects of Aronia berries have been summarized previously. The present review article focuses on the molecular targets of extracts of Aronia berries and the examples of promising lead compounds isolated from these berries, including cyanidin-3-O-galactoside, chlorogenic acid, quercetin, and ursolic acid. In addition, presented herein are clinical trial investigations for Aronia berries and their major components, including cancer clinical trials for chlorogenic acid and COVID-19 trial studies for quercetin. Additionally, the possible development of Aronia berries and their secondary metabolites as potential therapeutic agents is discussed. It is hoped that this contribution will help stimulate future investigations on Aronia berries for the continual improvement of human health. Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human health, including antidiabetic, anti-infective, antineoplastic, antiobesity, and antioxidant activities, as well as heart-, liver-, and neuroprotective effects. Thus far, phenolic compounds, such as anthocyanins, cyanidins, phenolic acids, proanthocyanidins, triterpenoids, and their analogues have been identified as the major active components of Aronia berries. These natural products possess potent antioxidant activity, which contributes to the majority of the other bioactivities observed for Aronia berries. The chemical components and the potential pharmaceutical or health-promoting effects of Aronia berries have been summarized previously. The present review article focuses on the molecular targets of extracts of Aronia berries and the examples of promising lead compounds isolated from these berries, including cyanidin-3-O-galactoside, chlorogenic acid, quercetin, and ursolic acid. In addition, presented herein are clinical trial investigations for Aronia berries and their major components, including cancer clinical trials for chlorogenic acid and COVID-19 trial studies for quercetin. Additionally, the possible development of Aronia berries and their secondary metabolites as potential therapeutic agents is discussed. It is hoped that this contribution will help stimulate future investigations on Aronia berries for the continual improvement of human health. Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human health, including antidiabetic, anti-infective, antineoplastic, antiobesity, and antioxidant activities, as well as heart-, liver-, and neuroprotective effects. Thus far, phenolic compounds, such as anthocyanins, cyanidins, phenolic acids, proanthocyanidins, triterpenoids, and their analogues have been identified as the major active components of Aronia berries. These natural products possess potent antioxidant activity, which contributes to the majority of the other bioactivities observed for Aronia berries. The chemical components and the potential pharmaceutical or health-promoting effects of Aronia berries have been summarized previously. The present review article focuses on the molecular targets of extracts of Aronia berries and the examples of promising lead compounds isolated from these berries, including cyanidin-3- -galactoside, chlorogenic acid, quercetin, and ursolic acid. In addition, presented herein are clinical trial investigations for Aronia berries and their major components, including cancer clinical trials for chlorogenic acid and COVID-19 trial studies for quercetin. Additionally, the possible development of Aronia berries and their secondary metabolites as potential therapeutic agents is discussed. It is hoped that this contribution will help stimulate future investigations on Aronia berries for the continual improvement of human health.
Audience	Academic
Author	Meyer, Gunnar Grebenc, Jessica R. Lei, Jizhou Ren, Yulin Frank, Tyler Slaughter, Ryan Gao, Yu G. Kinghorn, A. Douglas
AuthorAffiliation	1 Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA 3 Department of Horticulture and Crop Science, College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Columbus, OH 43210, USA 2 OSU South Centers, The Ohio State University, Columbus, OH 43210, USA
AuthorAffiliation_xml	– name: 1 Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA – name: 3 Department of Horticulture and Crop Science, College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Columbus, OH 43210, USA – name: 2 OSU South Centers, The Ohio State University, Columbus, OH 43210, USA
Author_xml	– sequence: 1 givenname: Yulin orcidid: 0000-0003-3667-1466 surname: Ren fullname: Ren, Yulin – sequence: 2 givenname: Tyler orcidid: 0000-0002-9282-9371 surname: Frank fullname: Frank, Tyler – sequence: 3 givenname: Gunnar surname: Meyer fullname: Meyer, Gunnar – sequence: 4 givenname: Jizhou surname: Lei fullname: Lei, Jizhou – sequence: 5 givenname: Jessica R. surname: Grebenc fullname: Grebenc, Jessica R. – sequence: 6 givenname: Ryan surname: Slaughter fullname: Slaughter, Ryan – sequence: 7 givenname: Yu G. orcidid: 0000-0002-9901-8790 surname: Gao fullname: Gao, Yu G. – sequence: 8 givenname: A. Douglas orcidid: 0000-0002-6647-8707 surname: Kinghorn fullname: Kinghorn, A. Douglas
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36431924$$D View this record in MEDLINE/PubMed
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Snippet	Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of...
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SubjectTerms	Amino acids Anthocyanin Anthocyanins - chemistry anti-infectives Antidiabetics Antifungal agents Antioxidants Antioxidants - chemistry antitumor effects Aronia melanocarpa Berries black chokeberry Cancer Cell cycle Cell growth Chemotherapy Chlorogenic Acid - analysis Clinical trials Colorectal cancer COVID-19 Drug Treatment Cyclin-dependent kinases Cytotoxicity Development and progression Enzymes Fruit Fruit - chemistry Health aspects Humans Kinases Liver cancer Lung cancer Metastasis Natural products Oncology, Experimental Oxidative stress phenolic constituents Photinia - chemistry Quercetin - analysis Review Stem cells
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Title	Potential Benefits of Black Chokeberry (Aronia melanocarpa) Fruits and Their Constituents in Improving Human Health
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