Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children
Aims/hypothesis During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this stud...
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| Vydáno v: | Diabetologia Ročník 61; číslo 1; s. 193 - 202 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Berlin/Heidelberg
Springer Berlin Heidelberg
01.01.2018
Springer Nature B.V |
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| ISSN: | 0012-186X, 1432-0428, 1432-0428 |
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| Abstract | Aims/hypothesis
During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the
HLA-DQ 6.2
haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes.
Methods
In The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes. In October 2009, when the mass vaccination began, 3401 children at risk for islet autoimmunity and type 1 diabetes were followed in Sweden and Finland. Vaccinations were recorded and autoantibodies against insulin, GAD65 and insulinoma-associated protein 2 were ascertained quarterly before the age of 4 years and semi-annually thereafter.
Results
By 5 August 2010, 2413 of the 3401 (71%) children observed as at risk for an islet autoantibody or type 1 diabetes on 1 October 2009 had been vaccinated with Pandemrix®. By 31 July 2016, 232 children had at least one islet autoantibody before 10 years of age, 148 had multiple islet autoantibodies and 96 had developed type 1 diabetes. The risk of islet autoimmunity was not increased among vaccinated children. The HR (95% CI) for the appearance of at least one islet autoantibody was 0.75 (0.55, 1.03), at least two autoantibodies was 0.85 (0.57, 1.26) and type 1 diabetes was 0.67 (0.42, 1.07). In Finland, but not in Sweden, vaccinated children had a lower risk of islet autoimmunity (0.47 [0.29, 0.75]), multiple autoantibodies (0.50 [0.28, 0.90]) and type 1 diabetes (0.38 [0.20, 0.72]) compared with those who did not receive Pandemrix®. The analyses were adjusted for confounding factors.
Conclusions/interpretation
Children with an increased genetic risk for type 1 diabetes who received the Pandemrix® vaccine during the A/H1N1 2009 pandemic had no increased risk of islet autoimmunity, multiple islet autoantibodies or type 1 diabetes. In Finland, the vaccine was associated with a reduced risk of islet autoimmunity and type 1 diabetes. |
|---|---|
| AbstractList | During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes.AIMS/HYPOTHESISDuring the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes.In The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes. In October 2009, when the mass vaccination began, 3401 children at risk for islet autoimmunity and type 1 diabetes were followed in Sweden and Finland. Vaccinations were recorded and autoantibodies against insulin, GAD65 and insulinoma-associated protein 2 were ascertained quarterly before the age of 4 years and semi-annually thereafter.METHODSIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes. In October 2009, when the mass vaccination began, 3401 children at risk for islet autoimmunity and type 1 diabetes were followed in Sweden and Finland. Vaccinations were recorded and autoantibodies against insulin, GAD65 and insulinoma-associated protein 2 were ascertained quarterly before the age of 4 years and semi-annually thereafter.By 5 August 2010, 2413 of the 3401 (71%) children observed as at risk for an islet autoantibody or type 1 diabetes on 1 October 2009 had been vaccinated with Pandemrix®. By 31 July 2016, 232 children had at least one islet autoantibody before 10 years of age, 148 had multiple islet autoantibodies and 96 had developed type 1 diabetes. The risk of islet autoimmunity was not increased among vaccinated children. The HR (95% CI) for the appearance of at least one islet autoantibody was 0.75 (0.55, 1.03), at least two autoantibodies was 0.85 (0.57, 1.26) and type 1 diabetes was 0.67 (0.42, 1.07). In Finland, but not in Sweden, vaccinated children had a lower risk of islet autoimmunity (0.47 [0.29, 0.75]), multiple autoantibodies (0.50 [0.28, 0.90]) and type 1 diabetes (0.38 [0.20, 0.72]) compared with those who did not receive Pandemrix®. The analyses were adjusted for confounding factors.RESULTSBy 5 August 2010, 2413 of the 3401 (71%) children observed as at risk for an islet autoantibody or type 1 diabetes on 1 October 2009 had been vaccinated with Pandemrix®. By 31 July 2016, 232 children had at least one islet autoantibody before 10 years of age, 148 had multiple islet autoantibodies and 96 had developed type 1 diabetes. The risk of islet autoimmunity was not increased among vaccinated children. The HR (95% CI) for the appearance of at least one islet autoantibody was 0.75 (0.55, 1.03), at least two autoantibodies was 0.85 (0.57, 1.26) and type 1 diabetes was 0.67 (0.42, 1.07). In Finland, but not in Sweden, vaccinated children had a lower risk of islet autoimmunity (0.47 [0.29, 0.75]), multiple autoantibodies (0.50 [0.28, 0.90]) and type 1 diabetes (0.38 [0.20, 0.72]) compared with those who did not receive Pandemrix®. The analyses were adjusted for confounding factors.Children with an increased genetic risk for type 1 diabetes who received the Pandemrix® vaccine during the A/H1N1 2009 pandemic had no increased risk of islet autoimmunity, multiple islet autoantibodies or type 1 diabetes. In Finland, the vaccine was associated with a reduced risk of islet autoimmunity and type 1 diabetes.CONCLUSIONS/INTERPRETATIONChildren with an increased genetic risk for type 1 diabetes who received the Pandemrix® vaccine during the A/H1N1 2009 pandemic had no increased risk of islet autoimmunity, multiple islet autoantibodies or type 1 diabetes. In Finland, the vaccine was associated with a reduced risk of islet autoimmunity and type 1 diabetes. Aims/hypothesis: During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes. Methods: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes. In October 2009, when the mass vaccination began, 3401 children at risk for islet autoimmunity and type 1 diabetes were followed in Sweden and Finland. Vaccinations were recorded and autoantibodies against insulin, GAD65 and insulinoma-associated protein 2 were ascertained quarterly before the age of 4 years and semi-annually thereafter. Results: By 5 August 2010, 2413 of the 3401 (71%) children observed as at risk for an islet autoantibody or type 1 diabetes on 1 October 2009 had been vaccinated with Pandemrix®. By 31 July 2016, 232 children had at least one islet autoantibody before 10 years of age, 148 had multiple islet autoantibodies and 96 had developed type 1 diabetes. The risk of islet autoimmunity was not increased among vaccinated children. The HR (95% CI) for the appearance of at least one islet autoantibody was 0.75 (0.55, 1.03), at least two autoantibodies was 0.85 (0.57, 1.26) and type 1 diabetes was 0.67 (0.42, 1.07). In Finland, but not in Sweden, vaccinated children had a lower risk of islet autoimmunity (0.47 [0.29, 0.75]), multiple autoantibodies (0.50 [0.28, 0.90]) and type 1 diabetes (0.38 [0.20, 0.72]) compared with those who did not receive Pandemrix®. The analyses were adjusted for confounding factors. Conclusions/interpretation: Children with an increased genetic risk for type 1 diabetes who received the Pandemrix® vaccine during the A/H1N1 2009 pandemic had no increased risk of islet autoimmunity, multiple islet autoantibodies or type 1 diabetes. In Finland, the vaccine was associated with a reduced risk of islet autoimmunity and type 1 diabetes. During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes. In The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes. In October 2009, when the mass vaccination began, 3401 children at risk for islet autoimmunity and type 1 diabetes were followed in Sweden and Finland. Vaccinations were recorded and autoantibodies against insulin, GAD65 and insulinoma-associated protein 2 were ascertained quarterly before the age of 4 years and semi-annually thereafter. By 5 August 2010, 2413 of the 3401 (71%) children observed as at risk for an islet autoantibody or type 1 diabetes on 1 October 2009 had been vaccinated with Pandemrix®. By 31 July 2016, 232 children had at least one islet autoantibody before 10 years of age, 148 had multiple islet autoantibodies and 96 had developed type 1 diabetes. The risk of islet autoimmunity was not increased among vaccinated children. The HR (95% CI) for the appearance of at least one islet autoantibody was 0.75 (0.55, 1.03), at least two autoantibodies was 0.85 (0.57, 1.26) and type 1 diabetes was 0.67 (0.42, 1.07). In Finland, but not in Sweden, vaccinated children had a lower risk of islet autoimmunity (0.47 [0.29, 0.75]), multiple autoantibodies (0.50 [0.28, 0.90]) and type 1 diabetes (0.38 [0.20, 0.72]) compared with those who did not receive Pandemrix®. The analyses were adjusted for confounding factors. Children with an increased genetic risk for type 1 diabetes who received the Pandemrix® vaccine during the A/H1N1 2009 pandemic had no increased risk of islet autoimmunity, multiple islet autoantibodies or type 1 diabetes. In Finland, the vaccine was associated with a reduced risk of islet autoimmunity and type 1 diabetes. Aims/hypothesis During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes. Methods In The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes. In October 2009, when the mass vaccination began, 3401 children at risk for islet autoimmunity and type 1 diabetes were followed in Sweden and Finland. Vaccinations were recorded and autoantibodies against insulin, GAD65 and insulinoma-associated protein 2 were ascertained quarterly before the age of 4 years and semi-annually thereafter. Results By 5 August 2010, 2413 of the 3401 (71%) children observed as at risk for an islet autoantibody or type 1 diabetes on 1 October 2009 had been vaccinated with Pandemrix®. By 31 July 2016, 232 children had at least one islet autoantibody before 10 years of age, 148 had multiple islet autoantibodies and 96 had developed type 1 diabetes. The risk of islet autoimmunity was not increased among vaccinated children. The HR (95% CI) for the appearance of at least one islet autoantibody was 0.75 (0.55, 1.03), at least two autoantibodies was 0.85 (0.57, 1.26) and type 1 diabetes was 0.67 (0.42, 1.07). In Finland, but not in Sweden, vaccinated children had a lower risk of islet autoimmunity (0.47 [0.29, 0.75]), multiple autoantibodies (0.50 [0.28, 0.90]) and type 1 diabetes (0.38 [0.20, 0.72]) compared with those who did not receive Pandemrix®. The analyses were adjusted for confounding factors. Conclusions/interpretation Children with an increased genetic risk for type 1 diabetes who received the Pandemrix® vaccine during the A/H1N1 2009 pandemic had no increased risk of islet autoimmunity, multiple islet autoantibodies or type 1 diabetes. In Finland, the vaccine was associated with a reduced risk of islet autoimmunity and type 1 diabetes. Aims/hypothesisDuring the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes.MethodsIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes. In October 2009, when the mass vaccination began, 3401 children at risk for islet autoimmunity and type 1 diabetes were followed in Sweden and Finland. Vaccinations were recorded and autoantibodies against insulin, GAD65 and insulinoma-associated protein 2 were ascertained quarterly before the age of 4 years and semi-annually thereafter.ResultsBy 5 August 2010, 2413 of the 3401 (71%) children observed as at risk for an islet autoantibody or type 1 diabetes on 1 October 2009 had been vaccinated with Pandemrix®. By 31 July 2016, 232 children had at least one islet autoantibody before 10 years of age, 148 had multiple islet autoantibodies and 96 had developed type 1 diabetes. The risk of islet autoimmunity was not increased among vaccinated children. The HR (95% CI) for the appearance of at least one islet autoantibody was 0.75 (0.55, 1.03), at least two autoantibodies was 0.85 (0.57, 1.26) and type 1 diabetes was 0.67 (0.42, 1.07). In Finland, but not in Sweden, vaccinated children had a lower risk of islet autoimmunity (0.47 [0.29, 0.75]), multiple autoantibodies (0.50 [0.28, 0.90]) and type 1 diabetes (0.38 [0.20, 0.72]) compared with those who did not receive Pandemrix®. The analyses were adjusted for confounding factors.Conclusions/interpretationChildren with an increased genetic risk for type 1 diabetes who received the Pandemrix® vaccine during the A/H1N1 2009 pandemic had no increased risk of islet autoimmunity, multiple islet autoantibodies or type 1 diabetes. In Finland, the vaccine was associated with a reduced risk of islet autoimmunity and type 1 diabetes. |
| Author | Krischer, Jeffrey P. Elding Larsson, Helena Hagopian, William A. Toppari, Jorma Rewers, Marian J. Lönnrot, Maria She, Jin-Xiong Lynch, Kristian F. Haller, Michael J. Simell, Olli Ziegler, Anette-G. Hyöty, Heikki Akolkar, Beena Lernmark, Åke |
| Author_xml | – sequence: 1 givenname: Helena surname: Elding Larsson fullname: Elding Larsson, Helena email: helena.larsson@med.lu.se organization: Department of Clinical Sciences Malmö, Lund University CRC, Skåne University Hospital SUS – sequence: 2 givenname: Kristian F. surname: Lynch fullname: Lynch, Kristian F. organization: Health Informatics Institute, Morsani College of Medicine, University of South Florida – sequence: 3 givenname: Maria surname: Lönnrot fullname: Lönnrot, Maria organization: Faculty of Medicine and Life Sciences, University of Tampere, Department of Dermatology, Tampere University Hospital – sequence: 4 givenname: Michael J. surname: Haller fullname: Haller, Michael J. organization: Department of Pediatrics, University of Florida – sequence: 5 givenname: Åke surname: Lernmark fullname: Lernmark, Åke organization: Department of Clinical Sciences Malmö, Lund University CRC, Skåne University Hospital SUS – sequence: 6 givenname: William A. surname: Hagopian fullname: Hagopian, William A. organization: Pacific Northwest Diabetes Research Institute – sequence: 7 givenname: Jin-Xiong surname: She fullname: She, Jin-Xiong organization: Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University – sequence: 8 givenname: Olli surname: Simell fullname: Simell, Olli organization: Department of Pediatrics, Turku University Hospital – sequence: 9 givenname: Jorma surname: Toppari fullname: Toppari, Jorma organization: Department of Pediatrics, Turku University Hospital, Department of Physiology, Institute of Biomedicine, University of Turku – sequence: 10 givenname: Anette-G. surname: Ziegler fullname: Ziegler, Anette-G. organization: Institute of Diabetes Research, Helmholtz Zentrum München, and Klinikum rechts der Isar, Technische Universität München, Forschergruppe Diabetes e.V – sequence: 11 givenname: Beena surname: Akolkar fullname: Akolkar, Beena organization: National Institute of Diabetes & Digestive & Kidney Diseases – sequence: 12 givenname: Jeffrey P. surname: Krischer fullname: Krischer, Jeffrey P. organization: Health Informatics Institute, Morsani College of Medicine, University of South Florida – sequence: 13 givenname: Marian J. surname: Rewers fullname: Rewers, Marian J. organization: Barbara Davis Center for Childhood Diabetes, University of Colorado – sequence: 14 givenname: Heikki surname: Hyöty fullname: Hyöty, Heikki organization: Faculty of Medicine and Life Sciences, University of Tampere, Fimlab Laboratories, Pirkanmaa Hospital District |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28990147$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | The Author(s) 2017 Diabetologia is a copyright of Springer, (2017). All Rights Reserved. |
| Copyright_xml | – notice: The Author(s) 2017 – notice: Diabetologia is a copyright of Springer, (2017). All Rights Reserved. |
| CorporateAuthor | for the TEDDY Study Group TEDDY Study Group Strategiska forskningsområden (SFO) EXODIAB: Excellence of Diabetes Research in Sweden Faculty of Medicine Strategic research areas (SRA) Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Medicinska fakulteten Lund University Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö |
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| Keywords | Swine flu Type 1 diabetes Vaccination Islet autoimmunity Squalene Pandemrix Influenza vaccine |
| Language | English |
| License | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
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| References | Tuomilehto (CR26) 2013; 13 Nohynek, Jokinen, Partinen (CR8) 2012; 7 Krischer, Lynch, Schatz (CR17) 2015; 58 (CR16) 2014; 37 Andersson (CR23) 2017; 281 Babaya, Yu, Miao (CR15) 2009; 25 Morgan, Halliday, Campbell, Cardwell, Patterson (CR6) 2016; 59 Hagopian, Erlich, Lernmark (CR12) 2011; 12 (CR11) 2008; 1150 Valdes, Unanue, Hernandez (CR27) 2013; 11 Hiltunen, Lonnrot, Hyoty (CR5) 1999; 20 Uusitalo, Liu, Yang (CR19) 2016; 170 Nenna, Papoff, Moretti (CR28) 2011; 24 Persson (CR24) 2014; 276 Svensson, Ramelius, Nilsson (CR25) 2014; 79 Vaarala, Vuorela, Partinen (CR10) 2014; 9 Kondrashova, Nurminen, Patrikainen (CR29) 2015; 58 Bonifacio, Yu, Williams (CR14) 2010; 95 Poland, Ovsyannikova, Jacobson (CR20) 2008; 26 Pociot, Lernmark (CR2) 2016; 387 Persson, Granath, Askling, Ludvigsson, Olsson, Feltelius (CR21) 2014; 275 Rewers, Ludvigsson (CR1) 2016; 387 Partinen, Saarenpaa-Heikkila, Ilveskoski (CR9) 2012; 7 Andersson (CR22) 2014; 276 Ziegler, Rewers, Simell (CR4) 2013; 309 Dauvilliers, Montplaisir, Cochen (CR7) 2010; 33 Kiviniemi, Hermann, Nurmi (CR13) 2007; 9 Torn, Liu, Hagopian (CR18) 2016; 6 Torn, Hadley, Lee (CR3) 2015; 64 E Bonifacio (4448_CR14) 2010; 95 M Hiltunen (4448_CR5) 1999; 20 JP Krischer (4448_CR17) 2015; 58 M Rewers (4448_CR1) 2016; 387 AG Ziegler (4448_CR4) 2013; 309 Y Dauvilliers (4448_CR7) 2010; 33 F Pociot (4448_CR2) 2016; 387 WA Hagopian (4448_CR12) 2011; 12 O Vaarala (4448_CR10) 2014; 9 C Torn (4448_CR18) 2016; 6 GA Poland (4448_CR20) 2008; 26 I Persson (4448_CR21) 2014; 275 J Tuomilehto (4448_CR26) 2013; 13 L Andersson (4448_CR23) 2017; 281 E Morgan (4448_CR6) 2016; 59 U Uusitalo (4448_CR19) 2016; 170 C Valdes (4448_CR27) 2013; 11 M Svensson (4448_CR25) 2014; 79 I Persson (4448_CR24) 2014; 276 N Babaya (4448_CR15) 2009; 25 M Kiviniemi (4448_CR13) 2007; 9 R Nenna (4448_CR28) 2011; 24 A Kondrashova (4448_CR29) 2015; 58 The TEDDY Study Group (4448_CR11) 2008; 1150 H Nohynek (4448_CR8) 2012; 7 American Diabetes Association (4448_CR16) 2014; 37 L Andersson (4448_CR22) 2014; 276 C Torn (4448_CR3) 2015; 64 M Partinen (4448_CR9) 2012; 7 |
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Increased incidence of TID during the pandemic H1N1 influenza of 2009 in Chile publication-title: Pediatr Endocrinol Rev – volume: 9 start-page: e114361 year: 2014 ident: CR10 article-title: Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for Pandemrix-associated narcolepsy risk publication-title: PLoS One doi: 10.1371/journal.pone.0114361 – volume: 12 start-page: 733 year: 2011 end-page: 743 ident: CR12 article-title: The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants publication-title: Pediatr Diabetes doi: 10.1111/j.1399-5448.2011.00774.x – volume: 309 start-page: 2473 year: 2013 end-page: 2479 ident: CR4 article-title: Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children publication-title: JAMA doi: 10.1001/jama.2013.6285 – volume: 20 start-page: 207 year: 1999 end-page: 212 ident: CR5 article-title: Immunisation and type 1 diabetes mellitus: is there a link? publication-title: Drug Saf doi: 10.2165/00002018-199920030-00001 – volume: 275 start-page: 172 year: 2014 end-page: 190 ident: CR21 article-title: Risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix: a population- and registry-based cohort study with over 2 years of follow-up publication-title: J Intern Med doi: 10.1111/joim.12150 – volume: 33 start-page: 1428 year: 2010 end-page: 1430 ident: CR7 article-title: Post-H1N1 narcolepsy-cataplexy publication-title: Sleep doi: 10.1093/sleep/33.11.1428 – volume: 79 start-page: 137 year: 2014 end-page: 148 ident: CR25 article-title: Antibodies to influenza virus A/H1N1 hemagglutinin in type 1 diabetes children diagnosed before, during and after the SWEDISH A(H1N1)pdm09 vaccination campaign 2009–2010 publication-title: Scand J Immunol doi: 10.1111/sji.12138 – volume: 9 start-page: 460 year: 2007 end-page: 472 ident: CR13 article-title: A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (The Environmental Determinants of Diabetes in the Young) study publication-title: Diabetes Technol Ther doi: 10.1089/dia.2007.0229 – volume: 64 start-page: 1818 year: 2015 end-page: 1829 ident: CR3 article-title: Role of type 1 diabetes-associated SNPs on risk of autoantibody positivity in the TEDDY study publication-title: Diabetes doi: 10.2337/db14-1497 – volume: 37 start-page: S14 issue: Suppl 1 year: 2014 end-page: S80 ident: CR16 article-title: Standards of medical care in diabetes—2014 publication-title: Diabetes Care doi: 10.2337/dc14-S014 – volume: 7 start-page: e33536 year: 2012 ident: CR8 article-title: AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland publication-title: PLoS One doi: 10.1371/journal.pone.0033536 – volume: 387 start-page: 2331 year: 2016 end-page: 2339 ident: CR2 article-title: Genetic risk factors for type 1 diabetes publication-title: Lancet doi: 10.1016/S0140-6736(16)30582-7 – volume: 170 start-page: 20 year: 2016 end-page: 28 ident: CR19 article-title: Association of early exposure of probiotics and islet autoimmunity in the TEDDY study publication-title: JAMA Pediatr doi: 10.1001/jamapediatrics.2015.2757 – volume: 7 start-page: e33723 year: 2012 ident: CR9 article-title: Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland publication-title: PLoS One doi: 10.1371/journal.pone.0033723 – volume: 1150 start-page: 1 year: 2008 end-page: 13 ident: CR11 article-title: The Environmental Determinants of Diabetes in the Young (TEDDY) study publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1447.062 – volume: 281 start-page: 99 year: 2017 end-page: 101 ident: CR23 article-title: Hidden authority study data have come to light: besides narcolepsy, the swine influenza vaccine Pandemrix caused type 1 diabetes publication-title: J Intern Med doi: 10.1111/joim.12583 – volume: 58 start-page: 980 year: 2015 end-page: 987 ident: CR17 article-title: The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study publication-title: Diabetologia doi: 10.1007/s00125-015-3514-y – volume: 276 start-page: 414 year: 2014 end-page: 417 ident: CR22 article-title: Contradictory data on type 1 diabetes in a recently published article ‘Risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix: a population- and registry-based cohort study with over 2 years of follow-up’ (J Intern Med 2013) publication-title: J Intern Med doi: 10.1111/joim.12246 – volume: 59 start-page: 237 year: 2016 end-page: 243 ident: CR6 article-title: Vaccinations and childhood type 1 diabetes mellitus: a meta-analysis of observational studies publication-title: Diabetologia doi: 10.1007/s00125-015-3800-8 – volume: 13 start-page: 795 year: 2013 end-page: 804 ident: CR26 article-title: The emerging global epidemic of type 1 diabetes publication-title: Curr Diab Rep doi: 10.1007/s11892-013-0433-5 – volume: 387 start-page: 2340 year: 2016 end-page: 2348 ident: CR1 article-title: Environmental risk factors for type 1 diabetes publication-title: Lancet doi: 10.1016/S0140-6736(16)30507-4 – volume: 24 start-page: 651 year: 2011 end-page: 659 ident: CR28 article-title: Detection of respiratory viruses in the 2009 winter season in Rome: 2009 influenza A (H1N1) complications in children and concomitant type 1 diabetes onset publication-title: Int J Immunopathol Pharmacol doi: 10.1177/039463201102400311 – volume: 26 start-page: 6183 year: 2008 end-page: 6188 ident: CR20 article-title: Vaccine immunogenetics: bedside to bench to population publication-title: Vaccine doi: 10.1016/j.vaccine.2008.06.057 – volume: 276 start-page: 413 year: 2014 ident: CR24 article-title: Response to letter to the editor by Lars Andersson publication-title: J Intern Med doi: 10.1111/joim.12245 – volume: 58 start-page: 2592 year: 2015 end-page: 2595 ident: CR29 article-title: Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes publication-title: Diabetologia doi: 10.1007/s00125-015-3723-4 – volume: 6 start-page: 27887 year: 2016 ident: CR18 article-title: Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study publication-title: Sci Rep doi: 10.1038/srep27887 – volume: 25 start-page: 665 year: 2009 end-page: 670 ident: CR15 article-title: Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays publication-title: Diabetes Metab Res Rev doi: 10.1002/dmrr.1014 – volume: 37 start-page: S14 issue: Suppl 1 year: 2014 ident: 4448_CR16 publication-title: Diabetes Care doi: 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During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in... During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland.... Aims/hypothesisDuring the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden... Aims/hypothesis: During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in... |
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| SubjectTerms | Autoantibodies Autoantibodies - immunology Autoantibodies - metabolism Autoimmunity Autoimmunity - physiology Children Clinical Medicine Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - metabolism Endocrinology and Diabetes Endokrinologi och diabetes Female Finland Histocompatibility antigen HLA Human Physiology Humans Immunization Influenza A Virus, H1N1 Subtype - drug effects Influenza Vaccines - adverse effects Insulin Insulinoma Internal Medicine Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine & Public Health Metabolic Diseases Narcolepsy Neuroendocrine tumors Pandemics Sleep disorders Squalene Squalene - chemistry Vaccination Vaccines |
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| Title | Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children |
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