E-cadherin in contact inhibition and cancer

E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expressi...

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Veröffentlicht in:Oncogene Jg. 37; H. 35; S. 4769 - 4780
Hauptverfasser: Mendonsa, Alisha M., Na, Tae-Young, Gumbiner, Barry M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.08.2018
Nature Publishing Group
Schlagworte:
631/67/322
631/80/79/1902
Adherens junctions
Apoptosis
Biochemistry
Cadherins
Cancer
Cancer prevention
Cancer treatment
Cell adhesion
Cell adhesion & migration
Cell Biology
Cell proliferation
Cellular signal transduction
Contact inhibition
Developmental biology
E-cadherin
Embryonic development
Gene expression
Genetic aspects
Health aspects
Homeostasis
Human Genetics
Innovations
Internal Medicine
Medical schools
Medicine
Medicine & Public Health
Oncology
Pediatrics
Phenotypes
Proteins
Review Article
Universities and colleges
ISSN:0950-9232, 1476-5594, 1476-5594
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.
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ObjectType-Literature Review-3
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ISSN:0950-9232
1476-5594
1476-5594
DOI:10.1038/s41388-018-0304-2